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    Kit kit oncogene [ Mus musculus (house mouse) ]

    Gene ID: 16590, updated on 19-Jul-2016
    Official Symbol
    Kitprovided by MGI
    Official Full Name
    kit oncogeneprovided by MGI
    Primary source
    MGI:MGI:96677
    See related
    Ensembl:ENSMUSG00000005672 Vega:OTTMUSG00000016671
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    W; Bs; Fdc; Ssm; SCO1; SCO5; SOW3; CD117; c-KIT; Tr-kit; Gsfsco1; Gsfsco5; Gsfsow3
    Summary
    The c-Kit proto-oncogene is the cellular homolog of the transforming gene of a feline retrovirus (v-Kit). The c-kit protein includes characteristics of a protein kinase transmembrane receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    5 C3.3; 5 39.55 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (75574987..75656722)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (75971012..76052747)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene platelet derived growth factor receptor, alpha polypeptide Neighboring gene microRNA 7025 Neighboring gene sterol O-acyltransferase 1 pseudogene Neighboring gene predicted gene, 32558 Neighboring gene predicted gene, 32727 Neighboring gene kinase insert domain protein receptor

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor signaling protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    stem cell factor receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein tyrosine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Fc receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Kit signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    actin cytoskeleton reorganization ISO
    Inferred from Sequence Orthology
    more info
     
    activation of MAPK activity ISO
    Inferred from Sequence Orthology
    more info
     
    cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to thyroid hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chemotaxis TAS
    Traceable Author Statement
    more info
    PubMed 
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    dendritic cell cytokine production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    detection of mechanical stimulus involved in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ectopic germ cell programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythropoietin-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    germ cell development TAS
    Traceable Author Statement
    more info
    PubMed 
    germ cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    glycosphingolipid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hematopoietic stem cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hemopoiesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    immature B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lymphoid progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    mast cell cytokine production ISO
    Inferred from Sequence Orthology
    more info
     
    mast cell degranulation ISO
    Inferred from Sequence Orthology
    more info
     
    mast cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    megakaryocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanocyte adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    melanocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    melanocyte migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid leukocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myeloid progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of programmed cell death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of programmed cell death IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    pigmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of JAK-STAT cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of long-term neuronal synaptic plasticity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of pseudopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of Stat1 protein ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of Stat3 protein ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of tyrosine phosphorylation of Stat5 protein ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vascular smooth muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation TAS
    Traceable Author Statement
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell shape IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of developmental pigmentation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of developmental pigmentation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to radiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell division ISO
    Inferred from Sequence Orthology
    more info
     
    somatic stem cell population maintenance ISO
    Inferred from Sequence Orthology
    more info
     
    spermatid development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    stem cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transmembrane receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    visual learning ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    mast/stem cell growth factor receptor Kit
    Names
    Dominant white spotting
    SCFR
    Steel Factor Receptor
    belly-spot
    c-kit proto-oncogene protein
    dominant spotting
    proto-oncogene c-Kit
    proto-oncogene tyrosine-protein kinase Kit
    spotted sterile male
    tyrosine-protein kinase Kit
    NP_001116205.1
    NP_066922.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122733.1NP_001116205.1  mast/stem cell growth factor receptor Kit isoform 1 precursor

      See identical proteins and their annotated locations for NP_001116205.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK047010, BC052457, BY123520
      Consensus CDS
      CCDS51525.1
      UniProtKB/Swiss-Prot
      P05532
      Related
      ENSMUSP00000005815, OTTMUSP00000018030, ENSMUST00000005815, OTTMUST00000040351
      Conserved Domains (7) summary
      cd00096
      Location:231307
      Ig; Immunoglobulin domain
      cd05860
      Location:314414
      Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
      smart00410
      Location:221310
      IG_like; Immunoglobulin like
      pfam07714
      Location:592926
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:48112
      Ig_2; Immunoglobulin domain
      cd05104
      Location:556930
      PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
      cl11960
      Location:427501
      Ig; Immunoglobulin domain
    2. NM_021099.3NP_066922.2  mast/stem cell growth factor receptor Kit isoform 2 precursor

      See identical proteins and their annotated locations for NP_066922.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS and encodes a shorter isoform, as compared to variant 1.
      Source sequence(s)
      AY536430, BC052457, BY017579
      Consensus CDS
      CCDS80302.1
      UniProtKB/Swiss-Prot
      P05532
      UniProtKB/TrEMBL
      F7DD14
      Related
      ENSMUSP00000116465, OTTMUSP00000018029, ENSMUST00000144270, OTTMUST00000040350
      Conserved Domains (7) summary
      cd00096
      Location:231307
      Ig; Immunoglobulin domain
      cd05860
      Location:314414
      Ig4_SCFR; Fourth immunoglobulin (Ig)-like domain of stem cell factor receptor (SCFR)
      smart00410
      Location:221310
      IG_like; Immunoglobulin like
      pfam07714
      Location:588922
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:48112
      Ig_2; Immunoglobulin domain
      cd05104
      Location:552926
      PTKc_Kit; Catalytic domain of the Protein Tyrosine Kinase, Kit
      cl11960
      Location:427501
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      75574987..75656722
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320687.1XP_017176176.1