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    Bmi1 Bmi1 polycomb ring finger oncogene [ Mus musculus (house mouse) ]

    Gene ID: 12151, updated on 9-Jul-2016
    Official Symbol
    Bmi1provided by MGI
    Official Full Name
    Bmi1 polycomb ring finger oncogeneprovided by MGI
    Primary source
    MGI:MGI:88174
    See related
    Ensembl:ENSMUSG00000026739 Vega:OTTMUSG00000011429
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bmi-1; Pcgf4; AW546694
    Orthologs
    Location:
    2 A3; 2 12.9 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (18677018..18686629)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (18598645..18608256)

    Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33355 Neighboring gene COMM domain containing 3 Neighboring gene uncharacterized LOC108168727 Neighboring gene sperm associated antigen 6 Neighboring gene predicted gene 3363

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA methylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    brain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular process TAS
    Traceable Author Statement
    more info
    PubMed 
    covalent chromatin modification IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic skeletal system morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hematopoietic stem cell homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    histone acetylation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    histone ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    humoral immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    in utero embryonic development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of B cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of immature T cell proliferation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    rostrocaudal neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somatic stem cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    heterochromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    polycomb complex protein BMI-1
    Names
    B lymphoma Mo-MLV insertion region 1
    polycomb group RING finger protein 4
    polycomb group ring finger 4

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007552.4NP_031578.2  polycomb complex protein BMI-1

      See identical proteins and their annotated locations for NP_031578.2

      Status: PROVISIONAL

      Source sequence(s)
      AL928680
      Consensus CDS
      CCDS15711.1
      UniProtKB/Swiss-Prot
      P25916
      UniProtKB/TrEMBL
      Q2LC58
      Related
      ENSMUSP00000028071, OTTMUSP00000012215, ENSMUST00000028071, OTTMUST00000026762
      Conserved Domains (1) summary
      cd00162
      Location:1756
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

      Range
      18677018..18686629
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497311.2XP_006497374.1  

      See identical proteins and their annotated locations for XP_006497374.1

      UniProtKB/Swiss-Prot
      P25916
      UniProtKB/TrEMBL
      Q2LC58
      Related
      ENSMUSP00000110300, ENSMUST00000051929
      Conserved Domains (1) summary
      cd00162
      Location:1756
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    2. XM_006497312.3XP_006497375.1  

      See identical proteins and their annotated locations for XP_006497375.1

      UniProtKB/Swiss-Prot
      P25916
      UniProtKB/TrEMBL
      Q2LC58
      Conserved Domains (1) summary
      cd00162
      Location:1756
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...