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NR2F2 nuclear receptor subfamily 2, group F, member 2 [ Homo sapiens (human) ]

Gene ID: 7026, updated on 17-May-2015
Official Symbol
NR2F2provided by HGNC
Official Full Name
nuclear receptor subfamily 2, group F, member 2provided by HGNC
Primary source
HGNC:HGNC:7976
See related
Ensembl:ENSG00000185551; HPRD:00139; MIM:107773; Vega:OTTHUMG00000149848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARP1; CHTD4; NF-E3; NR2F1; SVP40; COUPTFB; TFCOUP2; COUPTFII
Summary
This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Orthologs
See NR2F2 in MapViewer
Location:
15q26
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 15 NC_000015.10 (96325928..96340263)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (96869157..96883492)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369212 Neighboring gene NR2F2 antisense RNA 1 Neighboring gene uncharacterized LOC105370997 Neighboring gene uncharacterized LOC102724872 Neighboring gene uncharacterized LOC101927263 Neighboring gene microRNA 1469 Neighboring gene tubulin, alpha 1b pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Congenital heart defects, multiple types, 4
MedGen: CN187046 OMIM: 615779 GeneReviews: Not available
not available

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-10)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-07-10)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.
NHGRI GWA Catalog
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.
NHGRI GWA Catalog
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
NHGRI GWA Catalog
Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNFα inhibitors in patients with rheumatoid arthritis.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC117452

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
retinoic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
steroid hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transcription corepressor activity TAS
Traceable Author Statement
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
blood vessel morphogenesis IEA
Inferred from Electronic Annotation
more info
 
fertilization IEA
Inferred from Electronic Annotation
more info
 
forebrain development IEA
Inferred from Electronic Annotation
more info
 
intracellular receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
intracellular receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
intracellular receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
limb development IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
maternal placenta development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
placenta blood vessel development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
radial pattern formation IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
PubMed 
regulation of transcription involved in lymphatic endothelial cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
steroid hormone mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
trophoblast giant cell differentiation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
COUP transcription factor 2
Names
COUP transcription factor 2
ADP-ribosylation factor related protein 1
COUP transcription factor II
apolipoprotein A-I regulatory protein 1
apolipoprotein AI regulatory protein 1
chicken ovalbumin upstream promoter transcription factor 2
chicken ovalbumin upstream promoter-transcription factor I

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016753.1 RefSeqGene

    Range
    5001..19336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145155.1NP_001138627.1  COUP transcription factor 2 isoform b

    See identical proteins and their annotated locations for NP_001138627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC016251, BC106083
    Consensus CDS
    CCDS45358.1
    UniProtKB/Swiss-Prot
    P24468
    Conserved Domains (1) summary
    cd06948
    Location:44278
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
  2. NM_001145156.1NP_001138628.1  COUP transcription factor 2 isoform c

    See identical proteins and their annotated locations for NP_001138628.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode isoform c.
    Source sequence(s)
    AC016251, AK316086
    Consensus CDS
    CCDS45359.1
    UniProtKB/Swiss-Prot
    P24468
    Related
    ENSP00000377726, ENST00000394171
    Conserved Domains (1) summary
    cd06948
    Location:24258
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
  3. NM_001145157.1NP_001138629.1  COUP transcription factor 2 isoform c

    See identical proteins and their annotated locations for NP_001138629.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode isoform c.
    Source sequence(s)
    AC016251, BC034585
    Consensus CDS
    CCDS45359.1
    UniProtKB/Swiss-Prot
    P24468
    Conserved Domains (1) summary
    cd06948
    Location:24258
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
  4. NM_021005.3NP_066285.1  COUP transcription factor 2 isoform a

    See identical proteins and their annotated locations for NP_066285.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC016251, BC042897
    Consensus CDS
    CCDS10375.1
    UniProtKB/TrEMBL
    F1D8R0
    UniProtKB/Swiss-Prot
    P24468
    Related
    ENSP00000377721, OTTHUMP00000194781, ENST00000394166, OTTHUMT00000313534
    Conserved Domains (2) summary
    cd06948
    Location:177411
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    cd06958
    Location:79151
    NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p2 Primary Assembly

    Range
    96325928..96340263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018926.2 Alternate CHM1_1.1

    Range
    96711246..96725580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)