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TRIB2 tribbles pseudokinase 2 [ Homo sapiens (human) ]

Gene ID: 28951, updated on 19-Jul-2014
Official Symbol
TRIB2provided by HGNC
Official Full Name
tribbles pseudokinase 2provided by HGNC
Primary source
HGNC:30809
See related
Ensembl:ENSG00000071575; HPRD:18224; MIM:609462; Vega:OTTHUMG00000090575
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5FW; TRB2; GS3955
Summary
This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]
See TRIB2 in Epigenomics, MapViewer
Location:
2p24.3
Exon count :
3
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (12716872..12742734)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (12856998..12882860)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100506457 Neighboring gene suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 1 Neighboring gene microRNA 3681 Neighboring gene microRNA 3125 Neighboring gene uncharacterized LOC100506474 Neighboring gene nascent-polypeptide-associated complex alpha polypeptide pseudogene 4

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association of pericardial fat identifies a unique locus for ectopic fat.
NHGRI GWA Catalog
GWAS of dental caries patterns in the permanent dentition.
NHGRI GWA Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT nucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-protein transferase regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of interleukin-10 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of MAP kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
tribbles homolog 2
Names
tribbles homolog 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011644.1 

    Range
    5001..30863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_021643.3NP_067675.1  tribbles homolog 2

    See proteins identical to NP_067675.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AC009486, AY245544, DC379987
    Consensus CDS
    CCDS1683.1
    UniProtKB/Swiss-Prot
    Q92519
    Related
    ENSP00000155926, OTTHUMP00000115687, ENST00000155926, OTTHUMT00000207114
    Conserved Domains (2) summary
    cd00180
    Location:75306
    Blast Score: 317
    PKc; Catalytic domain of Protein Kinases
    smart00220
    Location:64308
    Blast Score: 405
    S_TKc; Serine/Threonine protein kinases, catalytic domain

RNA

  1. NR_027303.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and lacks the translational start codon used in variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC009486, AK129973, AK299146, AY245544, D87119, DC379987

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    12716872..12742734
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    12706690..12732553
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    12786401..12812238
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

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