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    Flii flightless I actin binding protein [ Mus musculus (house mouse) ]

    Gene ID: 14248, updated on 3-Jul-2016
    Official Symbol
    Fliiprovided by MGI
    Official Full Name
    flightless I actin binding proteinprovided by MGI
    Primary source
    MGI:MGI:1342286
    See related
    Ensembl:ENSMUSG00000002812 Vega:OTTMUSG00000007748
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fliih; 3632430F08Rik
    Summary
    This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
    Orthologs
    Location:
    11 37.81 cM; 11 B
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 11 NC_000077.6 (60714143..60727263, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (60527651..60540723, complement)

    Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene predicted gene 12616 Neighboring gene poly(A) binding protein, cytoplasmic 4 pseudogene Neighboring gene Uba52 pseudogene Neighboring gene lethal giant larvae homolog 1 (Drosophila) Neighboring gene microRNA 5100 Neighboring gene mitochondrial elongation factor 2 Neighboring gene topoisomerase (DNA) III alpha

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cytoskeleton organization TAS
    Traceable Author Statement
    more info
    PubMed 
    actin filament severing TAS
    Traceable Author Statement
    more info
    PubMed 
    multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    brush border IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    protein flightless-1 homolog
    Names
    cytoskeletal actin-modulating protein
    flightless I homolog

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302207.1NP_001289136.1  protein flightless-1 homolog isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in isoform 2, which is shorter by one amino acid, compared to isoform 1.
      Source sequence(s)
      AK014400, AK049365, AW047188, BB857715, CV784480
      Conserved Domains (8) summary
      cd11280
      Location:618702
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:10541153
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:491603
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:11641263
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:722836
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd00116
      Location:89352
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam13855
      Location:131186
      LRR_8; Leucine rich repeat
      sd00033
      Location:106128
      LRR_RI; leucine-rich repeat [structural motif]
    2. NM_022009.2NP_071292.1  protein flightless-1 homolog isoform 1

      See identical proteins and their annotated locations for NP_071292.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK014400, AK049365, AW047188, BB857715
      Consensus CDS
      CCDS24795.1
      UniProtKB/Swiss-Prot
      Q9JJ28
      Related
      ENSMUSP00000002889, OTTMUSP00000008167, ENSMUST00000002889, OTTMUST00000017709
      Conserved Domains (8) summary
      cd11280
      Location:619703
      gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
      cd11288
      Location:10551154
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:492604
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:11651264
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:723837
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd00116
      Location:89352
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam13855
      Location:131186
      LRR_8; Leucine rich repeat
      sd00033
      Location:106128
      LRR_RI; leucine-rich repeat [structural motif]

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000077.6 Reference GRCm38.p4 C57BL/6J

      Range
      60714143..60727263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)