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RETN resistin [ Homo sapiens (human) ]

Gene ID: 56729, updated on 14-Sep-2014
Official Symbol
RETNprovided by HGNC
Official Full Name
resistinprovided by HGNC
Primary source
HGNC:HGNC:20389
Locus tag
UNQ407/PRO1199
See related
Ensembl:ENSG00000104918; HPRD:05714; MIM:605565; Vega:OTTHUMG00000182503
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADSF; RSTN; XCP1; FIZZ3; RETN1
Summary
This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]
See RETN in Epigenomics, MapViewer
Location:
19p13.2
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 19 NC_000019.10 (7669086..7670454)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7733972..7735340)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PET100 homolog (S. cerevisiae) Neighboring gene Purkinje cell protein 2 Neighboring gene syntaxin binding protein 2 Neighboring gene mast cell-expressed membrane protein 1 Neighboring gene trafficking protein particle complex 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Diabetes mellitus type 2
MedGen: C0011860 OMIM: 125853 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect.
NHGRI GWA Catalog
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of resistin (RETN) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

  • Adipogenesis, organism-specific biosystem (from WikiPathways)
    Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126603, MGC126609

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hormone activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
aging IEA
Inferred from Electronic Annotation
more info
 
biological_process ND
No biological Data available
more info
 
fat cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
positive regulation of collagen metabolic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of progesterone secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell migration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
resistin
Names
resistin
resistin delta2
found in inflammatory zone 3
cysteine-rich secreted protein FIZZ3
adipose tissue-specific secretory factor
cysteine-rich secreted protein A12-alpha-like 2
c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023447.1 

    Range
    5001..6369
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193374.1NP_001180303.1  resistin precursor

    See proteins identical to NP_001180303.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY207314
    Consensus CDS
    CCDS12182.1
    UniProtKB/Swiss-Prot
    Q9HD89
    Conserved Domains (1) summary
    pfam06954
    Location:18106
    Resistin; Resistin
  2. NM_020415.3NP_065148.1  resistin precursor

    See proteins identical to NP_065148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF205952, BC069302
    Consensus CDS
    CCDS12182.1
    UniProtKB/Swiss-Prot
    Q9HD89
    Related
    ENSP00000221515, OTTHUMP00000269453, ENST00000221515, OTTHUMT00000461731
    Conserved Domains (1) summary
    pfam06954
    Location:18106
    Resistin; Resistin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000019.10 

    Range
    7669086..7670454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000151.1 

    Range
    7403771..7405139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018930.2 

    Range
    7733708..7735063
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)