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    DUX4L1 double homeobox 4 like 1 [ Homo sapiens (human) ]

    Gene ID: 22947, updated on 4-May-2015
    Official Symbol
    DUX4L1provided by HGNC
    Official Full Name
    double homeobox 4 like 1provided by HGNC
    Primary source
    See related
    Gene type
    RefSeq status
    Homo sapiens
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DUX4; DUX10
    This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]
    See DUX4L1 in Epigenomics, MapViewer
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (190084412..190085696)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (191005470..191006849)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene double homeobox 4 like 5 Neighboring gene double homeobox 4 like 4 Neighboring gene double homeobox 4 like 3 Neighboring gene double homeobox 4 like 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.


    1. NG_034172.2 

      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly


    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_027707.1: Suppressed sequence

      NG_027707.1: This RefSeq was permanently suppressed because GeneID 100288687 is now considered to be the functional DUX4 gene. The RefSeqGene for DUX4 is now NG_034189.1.
    2. NM_033178.4: Suppressed sequence

      NM_033178.4: This RefSeq was permanently suppressed because it is now thought that this gene does not encode a protein.