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    Rac1 RAS-related C3 botulinum substrate 1 [ Mus musculus (house mouse) ]

    Gene ID: 19353, updated on 28-Jul-2015
    Official Symbol
    Rac1provided by MGI
    Official Full Name
    RAS-related C3 botulinum substrate 1provided by MGI
    Primary source
    MGI:MGI:97845
    See related
    Ensembl:ENSMUSG00000001847; Vega:OTTMUSG00000020705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AL023026; D5Ertd559e
    Orthologs
    See Rac1 in Epigenomics, MapViewer
    Location:
    5 G2; 5 82.22 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (143505481..143528116, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (144266349..144288861, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene 9497 Neighboring gene diacylglycerol lipase, beta Neighboring gene family with sequence similarity 220, member A Neighboring gene cytohesin 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTP binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Rab GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Rho GDP-dissociation inhibitor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    histone deacetylase binding ISO
    Inferred from Sequence Orthology
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    thioesterase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Wnt signaling pathway, planar cell polarity pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    anatomical structure arrangement IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    auditory receptor cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bone resorption ISO
    Inferred from Sequence Orthology
    more info
     
    cell adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell motility ISO
    Inferred from Sequence Orthology
    more info
     
    cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell junction organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to mechanical stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cerebral cortex GABAergic interneuron development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cerebral cortex radially oriented cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    cochlea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dopaminergic neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic olfactory bulb interneuron precursor migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    engulfment of apoptotic cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial cell morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    homeostasis of number of cells within a tissue IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hyperosmotic response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    lamellipodium assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    localization within membrane ISO
    Inferred from Sequence Orthology
    more info
     
    mast cell chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of interleukin-23 production ISO
    Inferred from Sequence Orthology
    more info
     
    phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of focal adhesion assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lamellipodium assembly ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    positive regulation of neutrophil chemotaxis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of phosphatidylinositol 3-kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of stress fiber assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of fibroblast migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of neuron maturation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of respiratory burst ISO
    Inferred from Sequence Orthology
    more info
     
    ruffle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    ruffle organization ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    semaphorin-plexin signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    small GTPase mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    substrate adhesion-dependent cell spreading IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
     
    synaptic transmission, GABAergic IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with actin filament ISO
    Inferred from Sequence Orthology
    more info
     
    cell projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic membrane-bounded vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic ribonucleoprotein granule ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    extrinsic component of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    focal adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phagocytic cup IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ruffle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    ras-related C3 botulinum toxin substrate 1
    Names
    p21-Rac1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009007.2NP_033033.1  ras-related C3 botulinum toxin substrate 1 precursor

      See identical proteins and their annotated locations for NP_033033.1

      Status: VALIDATED

      Source sequence(s)
      BQ444803, CO425367, CX242948, CX566679
      Consensus CDS
      CCDS19843.1
      UniProtKB/TrEMBL
      K7Q7T7
      UniProtKB/Swiss-Prot
      P63001
      Conserved Domains (2) summary
      cd01871
      Location:3176
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3
      pfam00071
      Location:5177
      Ras; Ras family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      143505481..143528116
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504667.2XP_006504730.1  

      See identical proteins and their annotated locations for XP_006504730.1

      UniProtKB/TrEMBL
      Q3TLP8
      Related
      ENSMUSP00000098058, OTTMUSP00000022621, ENSMUST00000100489, OTTMUST00000049001
      Conserved Domains (2) summary
      cd01871
      Location:3195
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3
      pfam00071
      Location:5196
      Ras; Ras family

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      140552192..140574740
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)