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    FKH1 forkhead family transcription factor FKH1 [ Saccharomyces cerevisiae S288c ]

    Gene ID: 854675, updated on 5-Jun-2016
    Gene symbol
    FKH1
    Gene description
    forkhead family transcription factor FKH1
    Primary source
    SGD:S000001393
    Locus tag
    YIL131C
    Gene type
    protein coding
    RNA name
    forkhead family transcription factor FKH1
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288c (strain: S288c)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    See FKH1 in Map Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (100781..102235, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L16A Neighboring gene Csm2p Neighboring gene Asg1p Neighboring gene Tao3p

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Homology

    Gene Ontology Provided by GO

    Process Evidence Code Pubs
    anatomical structure morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to methylmercury IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to methylmercury IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    chromatin remodeling IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    donor selection IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    donor selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of pseudohyphal growth IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription elongation from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription elongation from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription involved in G1/S transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of transcription involved in G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of DNA-dependent DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of chromatin silencing at silent mating-type cassette IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of chromatin silencing at silent mating-type cassette IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription involved in G2/M transition of mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    termination of RNA polymerase II transcription IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    termination of RNA polymerase II transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    Names
    forkhead family transcription factor FKH1
    NP_012135.1
    • Forkhead family transcription factor; rate-limiting replication origin activator; evolutionarily conserved lifespan regulator; binds multiple chromosomal elements with distinct specificities, cell cycle dynamics; regulates transcription elongation, chromatin silencing at mating loci, expression of G2/M phase genes; facilitates clustering, activation of early-firing replication origins; binds HML recombination enhancer, regulates donor preference during mating-type switching

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      100781..102235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179479.1NP_012135.1  forkhead family transcription factor FKH1 [Saccharomyces cerevisiae S288c]

      See identical proteins and their annotated locations for NP_012135.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P40466
      Conserved Domains (3) summary
      COG5025
      Location:1484
      COG5025; Transcription factor of the Forkhead/HNF3 family [Transcription]
      cd00059
      Location:303379
      FH; Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as ...
      cd00060
      Location:67170
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...