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    Vdr vitamin D receptor [ Mus musculus (house mouse) ]

    Gene ID: 22337, updated on 22-Aug-2016
    Official Symbol
    Vdrprovided by MGI
    Official Full Name
    vitamin D receptorprovided by MGI
    Primary source
    MGI:MGI:103076
    See related
    Ensembl:ENSMUSG00000022479 Vega:OTTMUSG00000026431
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nr1i1
    Orthologs
    Location:
    15; 15 F1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (97854427..97908296, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (97684858..97738727, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene solute carrier family 48 (heme transporter), member 1 Neighboring gene histone deacetylase 7 Neighboring gene predicted gene, 33636 Neighboring gene predicted gene, 33690 Neighboring gene transmembrane protein 106C Neighboring gene collagen, type II, alpha 1 Neighboring gene uncharacterized LOC108168263

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    DNA binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    calcitriol binding ISO
    Inferred from Sequence Orthology
    more info
     
    calcitriol receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    lithocholic acid binding ISO
    Inferred from Sequence Orthology
    more info
     
    lithocholic acid receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    retinoid X receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    steroid hormone receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to transcription factor activity, sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    vitamin D binding ISO
    Inferred from Sequence Orthology
    more info
     
    contributes_to vitamin D response element binding ISO
    Inferred from Sequence Orthology
    more info
     
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    bile acid signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    calcium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    cellular calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intestinal absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lactation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mammary gland branching involved in pregnancy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    organ morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of apoptotic process involved in mammary gland involution IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of keratinocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of vitamin D 24-hydroxylase activity ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of calcidiol 1-monooxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    steroid hormone mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    vitamin D receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    RNA polymerase II transcription factor complex ISO
    Inferred from Sequence Orthology
    more info
     
    T-tubule ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with caveola ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    dense fibrillar component ISO
    Inferred from Sequence Orthology
    more info
     
    euchromatin ISO
    Inferred from Sequence Orthology
    more info
     
    heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear heterochromatin ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    receptor complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    vitamin D3 receptor
    Names
    1,25-dihydroxyvitamin D3 receptor
    nuclear receptor subfamily 1 group I member 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009504.4NP_033530.2  vitamin D3 receptor

      See identical proteins and their annotated locations for NP_033530.2

      Status: VALIDATED

      Source sequence(s)
      AC158787, AK030339
      Consensus CDS
      CCDS27784.1
      UniProtKB/Swiss-Prot
      P48281
      Related
      ENSMUSP00000023119, OTTMUSP00000032572, ENSMUST00000023119, OTTMUST00000065367
      Conserved Domains (2) summary
      cd06933
      Location:124421
      NR_LBD_VDR; The ligand binding domain of vitamin D receptors, a member of the nuclear receptor superfamily
      cd06955
      Location:16122
      NR_DBD_VDR; DNA-binding domain of vitamin D receptors (VDR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      97854427..97908296 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)