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    HIPK2 homeodomain interacting protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 28996, updated on 13-Aug-2016
    Official Symbol
    HIPK2provided by HGNC
    Official Full Name
    homeodomain interacting protein kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:14402
    See related
    Ensembl:ENSG00000064393 HPRD:06039; MIM:606868; Vega:OTTHUMG00000157704
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PRO0593
    Summary
    This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
    Orthologs
    Location:
    7q34
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 7 NC_000007.14 (139561570..139777894, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (139415730..139477693, complement) , (139246316..139342363, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) pseudogene 17 Neighboring gene C-type lectin domain family 2 member L Neighboring gene enhancer of rudimentary homolog (Drosophila) pseudogene 1 Neighboring gene uncharacterized LOC105375530 Neighboring gene thromboxane A synthase 1 Neighboring gene uncharacterized LOC107986853 Neighboring gene uncharacterized LOC105375532

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • C-MYB transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
      C-MYB transcription factor network, organism-specific biosystem
      C-MYB transcription factor network
    • Cardiac conduction, organism-specific biosystem (from REACTOME)
      Cardiac conduction, organism-specific biosystemThe normal sequence of contraction of atria and ventricles of the heart require activation of groups of cardiac cells. The mechanism must elicit rapid changes in heart rate and respond to changes in ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
      Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
    • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
      Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemIn this module, the processes by which calcium binding triggers actin - myosin interactions and force generation in smooth and striated muscle tissues are annotated.
    • Physiological factors, organism-specific biosystem (from REACTOME)
      Physiological factors, organism-specific biosystemCardiovascular homeostasis can be regulated by natriuretic peptides (Pandey 2014).
    • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
    • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
      Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
    • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
      Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
    • Wnt Signaling Pathway NetPath, organism-specific biosystem (from WikiPathways)
      Wnt Signaling Pathway NetPath, organism-specific biosystemWnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Bindi...
    • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
      YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...
    • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
      p53 pathway, organism-specific biosystem
      p53 pathway
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ23711, DKFZp686K02111

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    RNA polymerase II activating transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to RNA polymerase II transcription coactivator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    SMAD binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
     
    transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    virion binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    PML body organization TAS
    Traceable Author Statement
    more info
    PubMed 
    SMAD protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    adult walking behavior IEA
    Inferred from Electronic Annotation
    more info
     
    anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to hypoxia TAS
    Traceable Author Statement
    more info
    PubMed 
    embryonic camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    embryonic retina morphogenesis in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    erythrocyte differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    intrinsic apoptotic signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator TAS
    Traceable Author Statement
    more info
    PubMed 
    iris morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    lens induction in camera-type eye IEA
    Inferred from Electronic Annotation
    more info
     
    modulation by virus of host morphology or physiology NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-serine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of sequence-specific DNA binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription from RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transforming growth factor beta receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of signal transduction by p53 class mediator TAS
    Traceable Author Statement
    more info
     
    retina layer formation IEA
    Inferred from Electronic Annotation
    more info
     
    smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transforming growth factor beta receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    voluntary musculoskeletal movement IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    colocalizes_with PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    RNA polymerase II transcription factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear body TAS
    Traceable Author Statement
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    homeodomain-interacting protein kinase 2
    Names
    hHIPk2
    NP_001106710.1
    NP_073577.3

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113239.2NP_001106710.1  homeodomain-interacting protein kinase 2 isoform 2

      See identical proteins and their annotated locations for NP_001106710.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal segment in the CDS, as compared to variant 1. The resulting isoform (2) is shorter, as compared to isoform 1.
      Source sequence(s)
      AC005531, AF208291, AF326592, AI580907, CK818532
      Consensus CDS
      CCDS75666.1
      UniProtKB/Swiss-Prot
      Q9H2X6
      Related
      ENSP00000413724, OTTHUMP00000212369, ENST00000428878, OTTHUMT00000349431
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    2. NM_022740.4NP_073577.3  homeodomain-interacting protein kinase 2 isoform 1

      See identical proteins and their annotated locations for NP_073577.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the full-length isoform (1).
      Source sequence(s)
      AC005531, AF208291, AF326592, AI580907, CK818532
      Consensus CDS
      CCDS75667.1
      UniProtKB/Swiss-Prot
      Q9H2X6
      Related
      ENSP00000385571, OTTHUMP00000212368, ENST00000406875, OTTHUMT00000349430
      Conserved Domains (2) summary
      smart00220
      Location:199527
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:183537
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p7 Primary Assembly

      Range
      139561570..139777894 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715935.2XP_006715998.1  

      Conserved Domains (2) summary
      smart00220
      Location:192520
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:176530
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    2. XM_017012069.1XP_016867558.1  

    3. XM_011516080.2XP_011514382.1  

      Conserved Domains (2) summary
      smart00220
      Location:378706
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:362716
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    4. XM_011516078.2XP_011514380.1  

      Conserved Domains (2) summary
      smart00220
      Location:378706
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:362716
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    5. XM_011516079.2XP_011514381.1  

      Conserved Domains (2) summary
      smart00220
      Location:378706
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:362716
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    6. XM_011516077.2XP_011514379.1  

      Conserved Domains (2) summary
      smart00220
      Location:378706
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:362716
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2
    7. XM_011516081.2XP_011514383.1  

      Conserved Domains (2) summary
      smart00220
      Location:207535
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14227
      Location:191545
      STKc_HIPK2; Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      139180531..139411836 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)