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    CEACAM6 carcinoembryonic antigen related cell adhesion molecule 6 [ Homo sapiens (human) ]

    Gene ID: 4680, updated on 9-Jun-2016
    Official Symbol
    CEACAM6provided by HGNC
    Official Full Name
    carcinoembryonic antigen related cell adhesion molecule 6provided by HGNC
    Primary source
    HGNC:HGNC:1818
    See related
    Ensembl:ENSG00000086548 HPRD:01233; MIM:163980; Vega:OTTHUMG00000151064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NCA; CEAL; CD66c
    Summary
    This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]
    Orthologs
    Location:
    19q13.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (41755421..41772211)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42259398..42276113)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene carcinoembryonic antigen related cell adhesion molecule 7 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 5 Neighboring gene carcinoembryonic antigen related cell adhesion molecule 1 pseudogene Neighboring gene carcinoembryonic antigen related cell adhesion molecule 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 52

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Fibronectin matrix formation, organism-specific biosystem (from REACTOME)
      Fibronectin matrix formation, organism-specific biosystemFibronectin (FN1) is found in the extracellular matrix (ECM) of all cells as linear and branched networks that surround and connect neighbouring cells (Singh et al. 2010). Prior to matrix formation F...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    leukocyte migration TAS
    Traceable Author Statement
    more info
     
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    anchored component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 6
    Names
    Cluster of Differentiation 66c
    carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
    normal cross-reacting antigen

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_002483.6NP_002474.4  carcinoembryonic antigen-related cell adhesion molecule 6 preproprotein

      See identical proteins and their annotated locations for NP_002474.4

      Status: REVIEWED

      Source sequence(s)
      AK312542, BC005008, DA763751, M18728
      Consensus CDS
      CCDS12585.1
      UniProtKB/Swiss-Prot
      P40199
      Related
      ENSP00000199764, OTTHUMP00000199042, ENST00000199764, OTTHUMT00000321147
      Conserved Domains (4) summary
      cd00096
      Location:255313
      Ig; Immunoglobulin domain
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244312
      IG_like; Immunoglobulin like
      cl11960
      Location:146234
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      41755421..41772211
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011526990.1XP_011525292.1  

      See identical proteins and their annotated locations for XP_011525292.1

      Conserved Domains (4) summary
      cd00096
      Location:255313
      Ig; Immunoglobulin domain
      cd05774
      Location:36140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:244312
      IG_like; Immunoglobulin like
      cl11960
      Location:146234
      Ig; Immunoglobulin domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      42261055..42277743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)