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    Khk ketohexokinase [ Mus musculus (house mouse) ]

    Gene ID: 16548, updated on 29-Mar-2016
    Official Symbol
    Khkprovided by MGI
    Official Full Name
    ketohexokinaseprovided by MGI
    Primary source
    MGI:MGI:1096353
    See related
    Ensembl:ENSMUSG00000029162 Vega:OTTMUSG00000030395
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    5 B1; 5 16.9 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 5 NC_000071.6 (30921436..30931248)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (31224268..31233619)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ATP/GTP binding protein-like 5 Neighboring gene oligosaccharyltransferase complex subunit 4 (non-catalytic) Neighboring gene elastin microfibril interfacer 1 Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ketohexokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ketohexokinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    carbohydrate phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate IC
    Inferred by Curator
    more info
    PubMed 
    fructose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fructose metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    glycolytic process through fructose-1-phosphate IC
    Inferred by Curator
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of glycogen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to glucose ISO
    Inferred from Sequence Orthology
    more info
     
    response to insulin ISO
    Inferred from Sequence Orthology
    more info
     
    response to sucrose ISO
    Inferred from Sequence Orthology
    more info
     
    response to zinc ion ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    ketohexokinase
    Names
    hepatic fructokinase
    NP_032465.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310524.1NP_001297453.1  ketohexokinase isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC109606
      Consensus CDS
      CCDS80243.1
      UniProtKB/TrEMBL
      E9Q1Q9
      Conserved Domains (1) summary
      cd01939
      Location:5340
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    2. NM_001310525.1NP_001297454.1  ketohexokinase isoform 3

      See identical proteins and their annotated locations for NP_001297454.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC109606
      UniProtKB/TrEMBL
      A0A0J9YUK6
      Conserved Domains (1) summary
      cd01939
      Location:5250
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    3. NM_008439.4NP_032465.2  ketohexokinase isoform 2

      See identical proteins and their annotated locations for NP_032465.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC109606
      Consensus CDS
      CCDS39050.1
      UniProtKB/Swiss-Prot
      P97328
      UniProtKB/TrEMBL
      A0A0J9YU79
      Related
      ENSMUSP00000144050, OTTMUSP00000039427, ENSMUST00000201621, OTTMUST00000075286
      Conserved Domains (1) summary
      cd01939
      Location:5295
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p3 C57BL/6J

      Range
      30921436..30931248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503747.1XP_006503810.1  

      Related
      ENSMUSP00000031053, OTTMUSP00000039428, ENSMUST00000031053, OTTMUST00000075287
      Conserved Domains (1) summary
      cd01939
      Location:5340
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    2. XM_006503749.1XP_006503812.1  

      Related
      ENSMUSP00000143850, OTTMUSP00000039429, ENSMUST00000202752, OTTMUST00000075288
      Conserved Domains (1) summary
      cd01939
      Location:5295
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    3. XM_006503748.1XP_006503811.1  

      Conserved Domains (1) summary
      cd01939
      Location:5302
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...
    4. XM_006503750.1XP_006503813.1  

      Related
      ENSMUSP00000144226, OTTMUSP00000072017, ENSMUST00000201571, OTTMUST00000136447
      Conserved Domains (1) summary
      cd01939
      Location:5250
      Ketohexokinase; Ketohexokinase (fructokinase, KHK) catalyzes the phosphorylation of fructose to fructose-1-phosphate (F1P), the first step in the metabolism of dietary fructose. KHK can also phosphorylate several other furanose sugars. It is found in higher eukaryotes ...

    Alternate Mm_Celera

    Genomic

    1. AC_000027.1 Alternate Mm_Celera

      Range
      28401689..28411041
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)