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CD81 CD81 molecule [ Homo sapiens (human) ]

Gene ID: 975, updated on 27-Apr-2015
Official Symbol
CD81provided by HGNC
Official Full Name
CD81 moleculeprovided by HGNC
Primary source
HGNC:HGNC:1701
See related
Ensembl:ENSG00000110651; HPRD:08924; MIM:186845; Vega:OTTHUMG00000009892
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S5.7; CVID6; TAPA1; TSPAN28
Summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Orthologs
See CD81 in MapViewer
Location:
11p15.5
Exon count:
10
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 11 NC_000011.10 (2376177..2397419)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2397391..2418649)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene CD81 antisense RNA 1 Neighboring gene uncharacterized LOC105376519 Neighboring gene uncharacterized LOC105376520 Neighboring gene tumor suppressing subtransferable candidate 4 Neighboring gene transient receptor potential cation channel, subfamily M, member 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tetraspanin proteins, such as CD9, CD63, CD81, CD82, and CD231, are incorporated on the membrane of released virions in an HIV-1 envelope protein (Env)-independent manner and have the potential to inhibit HIV-1 Env-mediated infection PubMed
env Overexpression of CD81 and CD9 renders cells less susceptible to HIV-1 gp120/gp41-mediated syncytia formation; antibodies raised against CD9 and CD81 enhance syncytia formation PubMed
env CD81 localizes to endosome compartments and is incorporated into the viral envelope of macrophage-derived HIV-1 particles PubMed
Nef nef Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD81 (TSPAN28) PubMed
nef HIV-1 Nef increases the production of exosomes, which form at the plasma membrane and co-localizes with plasma membrane-associated proteins ICAM1, CD81, and Lck in Jurkat PubMed
Pr55(Gag) gag HIV-1 Gag recruits and traps CD81 to Gag assembly sites at the plasma membrane PubMed
gag HIV-1 Gag proteins co-localize with CD63 and CD81 in intracellular exosomes PubMed
gag HIV-1 Gag P99A mutation reduces its co-localization with tetraspanin-enriched microdomain marker CD81 and lipid raft marker CD59 PubMed
gag Tetherin co-localizes with HIV-1 Gag in CD81- and CD63-enriched intracellular virus-containing compartments in macrophages, and that a separate population of tetherin is located in the TGN PubMed
gag In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding PubMed
Vpu vpu HIV-1 Vpu co-localizes with CD81 in HIV-1-infected CEMss T cells PubMed
vpu Both HIV-1 Nef and Vpu downregulate the cell surface expression of CD81 (TSPAN28) PubMed
capsid gag Infection of monocyte-derived macrophages with HIV-1 redistributes viperin from ER into foci, which significantly co-localizes with p24 and CD81 PubMed
matrix gag In the absence of Vpu, Env accumulates extensively within clathrin-coated endosomal structures, including the viral proteins Gag and MA; the tetraspanins CD63 and CD81; the adaptor protein complex AP-3; and AIP1/ALIX, a cellular cofactor for viral budding PubMed

Go to the HIV-1, Human Interaction Database

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • B Cell Receptor Signaling Pathway, organism-specific biosystem (from WikiPathways)
    B Cell Receptor Signaling Pathway, organism-specific biosystemThe B cell receptor includes membrane ?? heavy chain molecules bound to a light chain and an Ig alpha (CD79A)/Ig beta (CD79B) heterodimer. Activation of the B cell receptor involves phosphorylation o...
  • B cell receptor signaling pathway, organism-specific biosystem (from KEGG)
    B cell receptor signaling pathway, organism-specific biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • B cell receptor signaling pathway, conserved biosystem (from KEGG)
    B cell receptor signaling pathway, conserved biosystemB cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystem (from REACTOME)
    Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell, organism-specific biosystemA number of receptors and cell adhesion molecules play a key role in modifying the response of cells of lymphoid origin (such as B-, T- and NK cells) to self and tumor antigens, as well as to pathoge...
  • Malaria, organism-specific biosystem (from KEGG)
    Malaria, organism-specific biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
  • Malaria, conserved biosystem (from KEGG)
    Malaria, conserved biosystemPlasmodium protozoa are parasites that account for malaria infection. Sporozoite forms of the parasite are injected by mosquito bites under the skin and are carried to the liver where they develop in...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class II protein complex binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
PubMed 
immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
CD81 antigen
Names
CD81 antigen
26 kDa cell surface protein TAPA-1
CD81 antigen (target of antiproliferative antibody 1)
tetraspanin-28
tspan-28

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023386.1 RefSeqGene

    Range
    3861..25103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_142

mRNA and Protein(s)

  1. NM_001297649.1NP_001284578.1  CD81 antigen isoform 2

    See identical proteins and their annotated locations for NP_001284578.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon and initiates translation at an alternate start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AI334163, BC093047, BP323362
    Consensus CDS
    CCDS73240.1
    UniProtKB/TrEMBL
    E9PJK1
    UniProtKB/Swiss-Prot
    P60033
    Conserved Domains (2) summary
    cd03151
    Location:42131
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:1159
    Tetraspannin; Tetraspanin family
  2. NM_004356.3NP_004347.1  CD81 antigen isoform 1

    See identical proteins and their annotated locations for NP_004347.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC002978, BG397506, BQ709484, CB055265, M33680
    Consensus CDS
    CCDS7734.1
    UniProtKB/TrEMBL
    A0A024RCB7
    UniProtKB/Swiss-Prot
    P60033
    Related
    ENSP00000263645, OTTHUMP00000011528, ENST00000263645, OTTHUMT00000027357
    Conserved Domains (2) summary
    cd03151
    Location:113202
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:9230
    Tetraspannin; Tetraspanin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p2 Primary Assembly

    Range
    2376177..2397419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011520492.1XP_011518794.1  

    See identical proteins and their annotated locations for XP_011518794.1

    Conserved Domains (2) summary
    cd03151
    Location:106195
    CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
    pfam00335
    Location:16223
    Tetraspannin; Tetraspanin family

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 Alternate CHM1_1.1

    Range
    2396358..2417522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)