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DDR2 discoidin domain receptor tyrosine kinase 2 [ Homo sapiens (human) ]

Gene ID: 4921, updated on 11-Sep-2014
Official Symbol
DDR2provided by HGNC
Official Full Name
discoidin domain receptor tyrosine kinase 2provided by HGNC
Primary source
HGNC:HGNC:2731
Locus tag
RP11-572K18.1
See related
Ensembl:ENSG00000162733; HPRD:01868; MIM:191311; Vega:OTTHUMG00000034423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TKT; MIG20a; NTRKR3; TYRO10
Summary
Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
See DDR2 in Epigenomics, MapViewer
Location:
1q23.3
Exon count:
22
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (162631265..162786619)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (162602228..162756409)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724358 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene chromosome 1 open reading frame 110

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase collagen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane receptor protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
biomineral tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
chondrocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
chondrocyte proliferation TAS
Traceable Author Statement
more info
PubMed 
collagen fibril organization ISS
Inferred from Sequence or Structural Similarity
more info
 
collagen-activated tyrosine kinase receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
endochondral bone growth ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
 
positive regulation of extracellular matrix disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast migration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of fibroblast migration TAS
Traceable Author Statement
more info
PubMed 
positive regulation of fibroblast proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
 
regulation of extracellular matrix disassembly TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
 
focal adhesion IDA
Inferred from Direct Assay
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
discoidin domain-containing receptor 2
Names
discoidin domain-containing receptor 2
tyrosylprotein kinase
hydroxyaryl-protein kinase
discoidin domain receptor 2
tyrosine-protein kinase TYRO10
CD167 antigen-like family member B
cell migration-inducing protein 20
migration-inducing gene 16 protein
receptor protein-tyrosine kinase TKT
discoidin domain receptor family, member 2
neurotrophic tyrosine kinase receptor related 3
neurotrophic tyrosine kinase, receptor-related 3
discoidin domain-containing receptor tyrosine kinase 2
NP_001014796.1
NP_006173.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016290.1 

    Range
    5001..153028
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014796.1NP_001014796.1  discoidin domain-containing receptor 2 precursor

    See proteins identical to NP_001014796.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AA148473, BC052998, CF994640
    Consensus CDS
    CCDS1241.1
    UniProtKB/TrEMBL
    A0A024R906
    UniProtKB/Swiss-Prot
    Q16832
    Conserved Domains (3) summary
    cd05095
    Location:557851
    PTKc_DDR2; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
    smart00221
    Location:563849
    STYKc; Protein kinase; unclassified specificity
    cd00057
    Location:32184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. NM_006182.2NP_006173.2  discoidin domain-containing receptor 2 precursor

    See proteins identical to NP_006173.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA148473, BC052998, CF994640, X74764
    Consensus CDS
    CCDS1241.1
    UniProtKB/TrEMBL
    A0A024R906
    UniProtKB/Swiss-Prot
    Q16832
    Related
    ENSP00000356898, OTTHUMP00000038368, ENST00000367921, OTTHUMT00000097650
    Conserved Domains (3) summary
    cd05095
    Location:557851
    PTKc_DDR2; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
    smart00221
    Location:563849
    STYKc; Protein kinase; unclassified specificity
    cd00057
    Location:32184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    162631265..162786619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006711344.1XP_006711407.1  

    See proteins identical to XP_006711407.1

    UniProtKB/TrEMBL
    A0A024R906
    UniProtKB/Swiss-Prot
    Q16832
    Related
    ENSP00000356899, OTTHUMP00000032332, ENST00000367922, OTTHUMT00000083213
    Conserved Domains (3) summary
    cd05095
    Location:557851
    PTKc_DDR2; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
    smart00221
    Location:563849
    STYKc; Protein kinase; unclassified specificity
    cd00057
    Location:32184
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_006711345.1XP_006711408.1  

    Conserved Domains (1) summary
    cd00057
    Location:44196
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_005245221.2XP_005245278.1  

    Conserved Domains (3) summary
    cd05095
    Location:569863
    PTKc_DDR2; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
    smart00221
    Location:575861
    STYKc; Protein kinase; unclassified specificity
    cd00057
    Location:44196
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    133847299..133995362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    164024739..164172823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)