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FDPS farnesyl diphosphate synthase [ Homo sapiens (human) ]

Gene ID: 2224, updated on 26-Aug-2014
Official Symbol
FDPSprovided by HGNC
Official Full Name
farnesyl diphosphate synthaseprovided by HGNC
Primary source
HGNC:3631
See related
Ensembl:ENSG00000160752; HPRD:00606; MIM:134629; Vega:OTTHUMG00000013909
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPS; FPPS
Summary
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
See FDPS in Epigenomics, MapViewer
Location:
1q22
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 1 NC_000001.11 (155308748..155320666)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (155278539..155290457)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CDC-like kinase 2 Neighboring gene hyperpolarization activated cyclic nucleotide-gated potassium channel 3 Neighboring gene pyruvate kinase, liver and RBC Neighboring gene RUSC1 antisense RNA 1 Neighboring gene RUN and SH3 domain containing 1 Neighboring gene ash1 (absent, small, or homeotic)-like (Drosophila) Neighboring gene microRNA 555

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Activation of gene expression by SREBF (SREBP), organism-specific biosystem (from REACTOME)
    Activation of gene expression by SREBF (SREBP), organism-specific biosystemAfter transiting to the nucleus SREBPs (SREBP1A/1C/2, SREBFs) bind short sequences, sterol regulatory elements (SREs), in the promoters of target genes (reviewed in Eberle et al. 2004, Weber et al. 2...
  • Cholesterol biosynthesis, organism-specific biosystem (from WikiPathways)
    Cholesterol biosynthesis, organism-specific biosystemCholesterol is a waxy steroid metabolite found in the cell membranes and transported in the blood plasma of all animals. It is an essential structural component of mammalian cell membranes, where it ...
  • Cholesterol biosynthesis, organism-specific biosystem (from REACTOME)
    Cholesterol biosynthesis, organism-specific biosystemCholesterol is synthesized de novo from from acetyl CoA. The overall synthetic process is outlined in the figure below. Enzymes whose regulation plays a major role in determining the rate of choleste...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Influenza A, organism-specific biosystem (from KEGG)
    Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Influenza A, conserved biosystem (from KEGG)
    Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystem (from REACTOME)
    Regulation of cholesterol biosynthesis by SREBP (SREBF), organism-specific biosystemSterol regulatory element binding proteins (SREBPs, SREBFs) respond to low cholesterol concentrations by transiting to the nucleus and activating genes involved in cholesterol and lipid biosynthesis ...
  • SREBP signalling, organism-specific biosystem (from WikiPathways)
    SREBP signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...
  • Terpenoid backbone biosynthesis, organism-specific biosystem (from KEGG)
    Terpenoid backbone biosynthesis, organism-specific biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
  • Terpenoid backbone biosynthesis, conserved biosystem (from KEGG)
    Terpenoid backbone biosynthesis, conserved biosystemTerpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mev...
  • superpathway of cholesterol biosynthesis, organism-specific biosystem (from BIOCYC)
    superpathway of cholesterol biosynthesis, organism-specific biosystem
    superpathway of cholesterol biosynthesis
  • superpathway of cholesterol biosynthesis, conserved biosystem (from BIOCYC)
    superpathway of cholesterol biosynthesis, conserved biosystemThe sequence of reactions in the cholesterol biosynthetic pathway may vary. This superpathway gives an overview of three possible routes of cholesterol biosynthesis. These routes exist because redu...
  • superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate), organism-specific biosystem (from BIOCYC)
    superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate), organism-specific biosystem
    superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
  • superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate), conserved biosystem (from BIOCYC)
    superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate), conserved biosystem|FRAME: GERANYLGERANYL-PP| (also known as geranylgeranyl pyrophosphate, or GGPP) is a crucial compound involved in the biosynthesis of a variety of terpenes and terpenoids, including central compound...
  • trans, trans-farnesyl diphosphate biosynthesis, organism-specific biosystem (from BIOCYC)
    trans, trans-farnesyl diphosphate biosynthesis, organism-specific biosystemGeneral Background : FARNESYL-PP (farnesyl pyrophosphate, FPP) is a crucial compound involved in the biosynthesis of a variety of terpenoids including sesquiterpenoids and sterols. Moreover, FPP is ...
  • trans, trans-farnesyl diphosphate biosynthesis, conserved biosystem (from BIOCYC)
    trans, trans-farnesyl diphosphate biosynthesis, conserved biosystemGeneral Background |FRAME: FARNESYL-PP| (farnesyl pyrophosphate, FPP) is a crucial compound involved in the biosynthesis of a variety of terpenoids including sesquiterpenoids and sterols. Moreover,...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dimethylallyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
 
geranyltranstransferase activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
Process Evidence Code Pubs
cholesterol biosynthetic process TAS
Traceable Author Statement
more info
 
farnesyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
geranyl diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
farnesyl pyrophosphate synthase
Names
farnesyl pyrophosphate synthase
FPP synthase
FPP synthetase
geranyltranstransferase
dimethylallyltranstransferase
(2E,6E)-farnesyl diphosphate synthase
farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
NP_001129293.1
NP_001129294.1
NP_001229753.1
NP_001229754.1
NP_001995.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135821.1NP_001129293.1  farnesyl pyrophosphate synthase isoform a

    See proteins identical to NP_001129293.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BE047993, D14697, DA610405
    Consensus CDS
    CCDS1110.1
    UniProtKB/Swiss-Prot
    P14324
    Related
    ENSP00000349078, OTTHUMP00000015807, ENST00000356657, OTTHUMT00000039053
    Conserved Domains (1) summary
    cd00685
    Location:106417
    Blast Score: 610
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
  2. NM_001135822.1NP_001129294.1  farnesyl pyrophosphate synthase isoform b

    See proteins identical to NP_001129294.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon at its 5' end and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus when compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AL139410, BE047993, CN346026, M29863
    Consensus CDS
    CCDS44241.1
    UniProtKB/Swiss-Prot
    P14324
    Related
    ENSP00000480142, ENST00000467076
    Conserved Domains (1) summary
    cd00685
    Location:40351
    Blast Score: 600
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
  3. NM_001242824.1NP_001229753.1  farnesyl pyrophosphate synthase isoform b

    See proteins identical to NP_001229753.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon at its 5' end and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus when compared to isoform a. Both variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AK291084, AL139410, BE047993, BP370037
    Consensus CDS
    CCDS44241.1
    UniProtKB/Swiss-Prot
    P14324
    Related
    ENSP00000391755, ENST00000447866
    Conserved Domains (1) summary
    cd00685
    Location:40351
    Blast Score: 600
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
  4. NM_001242825.1NP_001229754.1  farnesyl pyrophosphate synthase isoform c

    See proteins identical to NP_001229754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate exons at its 5' end and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (c) has a shorter N-terminus when compared to isoform a.
    Source sequence(s)
    AK291084, AL139410, BE047993, CD675633
    Consensus CDS
    CCDS72940.1
    UniProtKB/Swiss-Prot
    P14324
    Related
    ENSP00000483188, ENST00000611010
    Conserved Domains (1) summary
    cd00685
    Location:1246
    Blast Score: 447
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
  5. NM_002004.3NP_001995.1  farnesyl pyrophosphate synthase isoform a

    See proteins identical to NP_001995.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AL139410, BC010004, BE047993, CN346026
    Consensus CDS
    CCDS1110.1
    UniProtKB/Swiss-Prot
    P14324
    Related
    ENSP00000357340, OTTHUMP00000015808, ENST00000368356, OTTHUMT00000039054
    Conserved Domains (1) summary
    cd00685
    Location:106417
    Blast Score: 610
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000001.11 

    Range
    155308748..155320666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005244963.1XP_005245020.1  

    See proteins identical to XP_005245020.1

    UniProtKB/Swiss-Prot
    P14324
    Conserved Domains (1) summary
    cd00685
    Location:40351
    Blast Score: 600
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail
  2. XM_005244962.1XP_005245019.1  

    See proteins identical to XP_005245019.1

    UniProtKB/Swiss-Prot
    P14324
    Related
    ENSP00000478235, ENST00000612683
    Conserved Domains (1) summary
    cd00685
    Location:40351
    Blast Score: 600
    Trans_IPPS_HT; Trans-Isoprenyl Diphosphate Synthases, head-to-tail

Alternate HuRef

Genomic

  1. AC_000133.1 

    Range
    126640838..126652759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 

    Range
    156673976..156685898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)