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Trp63 transformation related protein 63 [ Mus musculus (house mouse) ]

Gene ID: 22061, updated on 18-Apr-2015
Official Symbol
Trp63provided by MGI
Official Full Name
transformation related protein 63provided by MGI
Primary source
MGI:MGI:1330810
See related
Ensembl:ENSMUSG00000022510; Vega:OTTMUSG00000021015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ket; P63; P73l; Tp63; P51/P63; AI462811; Trp53rp1
Summary
This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Orthologs
See Trp63 in MapViewer
Location:
16 B1; 16 17.37 cM
Exon count:
17
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 16 NC_000082.6 (25683763..25892103)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (25683851..25892174)

Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein H2 pseudogene Neighboring gene UPF0568 protein C14orf166 homolog Neighboring gene predicted gene, 27005 Neighboring gene predicted gene 4524 Neighboring gene prolyl 3-hydroxylase 2 Neighboring gene uncharacterized LOC105246092

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC115972

Gene Ontology Provided by MGI

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
WW domain binding ISO
Inferred from Sequence Orthology
more info
 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding ISO
Inferred from Sequence Orthology
more info
 
damaged DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding transcription factor activity IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
Inferred from Biological aspect of Ancestor
more info
 
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
anatomical structure formation involved in morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
cell aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to UV IBA
Inferred from Biological aspect of Ancestor
more info
 
chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cloacal septation IMP
Inferred from Mutant Phenotype
more info
PubMed 
ectoderm and mesoderm interaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermal cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermis development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell development IDA
Inferred from Direct Assay
more info
PubMed 
epithelial cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of planar polarity IDA
Inferred from Direct Assay
more info
PubMed 
establishment of skin barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
female genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
keratinocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
mitotic G1 DNA damage checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
 
morphogenesis of a polarized epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal aging IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
negative regulation of keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
odontogenesis of dentin-containing tooth IMP
Inferred from Mutant Phenotype
more info
PubMed 
organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
polarized epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell cycle G1/S phase transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of keratinocyte proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
prostatic bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
proximal/distal pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epidermal cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of nucleic acid-templated transcription IPI
Inferred from Physical Interaction
more info
PubMed 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
replicative cell aging ISO
Inferred from Sequence Orthology
more info
 
response to X-ray IBA
Inferred from Biological aspect of Ancestor
more info
 
response to gamma radiation IBA
Inferred from Biological aspect of Ancestor
more info
 
skeletal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skin morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
squamous basal epithelial stem cell differentiation involved in prostate gland acinus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
urinary bladder development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
intracellular IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
tumor protein 63
Names
tumor protein 63
transformation-related protein 63

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001127259.1NP_001120731.1  tumor protein 63 isoform a

    See identical proteins and their annotated locations for NP_001120731.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a, also known as TAp63alpha).
    Source sequence(s)
    AF075436, AK138305, BC090649
    Consensus CDS
    CCDS49809.1
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q5CZX0
    Related
    ENSMUSP00000110965, OTTMUSP00000023061, ENSMUST00000115310, OTTMUST00000049678
    Conserved Domains (5) summary
    cd08367
    Location:177358
    P53; P53 DNA-binding domain
    cd09572
    Location:543607
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    smart00454
    Location:541606
    SAM; Sterile alpha motif
    pfam07710
    Location:397432
    P53_tetramer; P53 tetramerization motif
    pfam08430
    Location:452534
    Fork_head_N; Forkhead N-terminal region
  2. NM_001127260.1NP_001120732.1  tumor protein 63 isoform b

    See identical proteins and their annotated locations for NP_001120732.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a coding exon in the 3' region, as compared to variant 1. The resulting isoform (b, also known as TAp63beta) has a shorter and different C-terminus, as compared to isoform a.
    Source sequence(s)
    AF075435, AK138305, BC090649
    Consensus CDS
    CCDS49810.1
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q5CZX0
    Related
    ENSMUSP00000067005, ENSMUST00000065523
    Conserved Domains (3) summary
    cd08367
    Location:177358
    P53; P53 DNA-binding domain
    pfam07710
    Location:397432
    P53_tetramer; P53 tetramerization motif
    pfam08430
    Location:452534
    Fork_head_N; Forkhead N-terminal region
  3. NM_001127261.1NP_001120733.1  tumor protein 63 isoform c

    See identical proteins and their annotated locations for NP_001120733.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal 12 nt segment and several 3' exons but has an alternate 3' exon, as compared to variant 1. The resulting isoform (c, also known as TAp63gamma) lacks internal 4 aa and has a shorter and different C-terminus, as compared to isoform a.
    Source sequence(s)
    AF075434, AK138305, AK140023, BC092537
    Consensus CDS
    CCDS49808.1
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q569E5
    Related
    ENSMUSP00000110963, ENSMUST00000115308
    Conserved Domains (2) summary
    cd08367
    Location:177358
    P53; P53 DNA-binding domain
    pfam07710
    Location:393428
    P53_tetramer; P53 tetramerization motif
  4. NM_001127262.1NP_001120734.1  tumor protein 63 isoform f

    See identical proteins and their annotated locations for NP_001120734.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is an alternate promoter product; it lacks several 5' exons and an internal exon in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (f, also known as DNp63beta) has shorter and different N- and C-termini, as compared to isoform a.
    Source sequence(s)
    AF075438, AK048623, BC090649
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q5CZX0
    Conserved Domains (2) summary
    cd08367
    Location:83264
    P53; P53 DNA-binding domain
    pfam07710
    Location:303338
    P53_tetramer; P53 tetramerization motif
  5. NM_001127263.1NP_001120735.1  tumor protein 63 isoform g

    See identical proteins and their annotated locations for NP_001120735.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) is an alternate promoter product; it lacks several 5' and 3' exons, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (g, also known as DNp63gamma) has shorter and different N- and C-termini, as compared to isoform a.
    Source sequence(s)
    AK140023, BC092537
    Consensus CDS
    CCDS49812.1
    UniProtKB/TrEMBL
    Q569E5
    Related
    ENSMUSP00000110960, OTTMUSP00000023064, ENSMUST00000115305, OTTMUST00000049681
    Conserved Domains (2) summary
    cd08367
    Location:83264
    P53; P53 DNA-binding domain
    pfam07710
    Location:303338
    P53_tetramer; P53 tetramerization motif
  6. NM_001127264.1NP_001120736.1  tumor protein 63 isoform e

    See identical proteins and their annotated locations for NP_001120736.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is an alternate promoter product; it lacks several 5' exons and an internal 12 nt segment, but has an alternate 5' exon, as compared to variant 1. The resulting isoform (e) has a shorter and different N-terminus, and lacks internal 4 aa, as compared to isoform a.
    Source sequence(s)
    AK048623, AK137253, BC090649
    Consensus CDS
    CCDS49811.1
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q3UVI3
    UniProtKB/TrEMBL
    Q5CZX0
    Related
    ENSMUSP00000110961, OTTMUSP00000023060, ENSMUST00000115306, OTTMUST00000049677
    Conserved Domains (5) summary
    cd08367
    Location:83264
    P53; P53 DNA-binding domain
    cd09572
    Location:445509
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    smart00454
    Location:443508
    SAM; Sterile alpha motif
    pfam07710
    Location:299334
    P53_tetramer; P53 tetramerization motif
    pfam08430
    Location:354436
    Fork_head_N; Forkhead N-terminal region
  7. NM_001127265.1NP_001120737.1  tumor protein 63 isoform h

    See identical proteins and their annotated locations for NP_001120737.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) is an alternate promoter product; it lacks several 5' and 3' exons and an internal 12 nt segment, but has alternate 5' and 3' exons, as compared to variant 1. The resulting isoform (h, also known as DNp63gamma) has shorter and different N- and C-termini, and lacks internal 4 aa, as compared to isoform a.
    Source sequence(s)
    AF075437, AK048623, AK140023, BC092537
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q569E5
    Conserved Domains (2) summary
    cd08367
    Location:83264
    P53; P53 DNA-binding domain
    pfam07710
    Location:299334
    P53_tetramer; P53 tetramerization motif
  8. NM_011641.2NP_035771.1  tumor protein 63 isoform d

    See identical proteins and their annotated locations for NP_035771.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is an alternate promoter product; it lacks several 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform (d, also known as DNp63alpha) has a shorter and different N-terminus, as compared to isoform a.
    Source sequence(s)
    AF075439, AK048623, BC090649
    Consensus CDS
    CCDS28085.1
    UniProtKB/Swiss-Prot
    O88898
    UniProtKB/TrEMBL
    Q5CZX0
    Related
    ENSMUSP00000038117, OTTMUSP00000023059, ENSMUST00000040231, OTTMUST00000049676
    Conserved Domains (5) summary
    cd08367
    Location:83264
    P53; P53 DNA-binding domain
    cd09572
    Location:449513
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    smart00454
    Location:447512
    SAM; Sterile alpha motif
    pfam07710
    Location:303338
    P53_tetramer; P53 tetramerization motif
    pfam08430
    Location:358440
    Fork_head_N; Forkhead N-terminal region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000082.6 Reference GRCm38.p3 C57BL/6J

    Range
    25683763..25892103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522000.1XP_006522063.1  

    Conserved Domains (5) summary
    cd08367
    Location:177358
    P53; P53 DNA-binding domain
    cd09572
    Location:539603
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    smart00454
    Location:537602
    SAM; Sterile alpha motif
    pfam07710
    Location:393428
    P53_tetramer; P53 tetramerization motif
    pfam08430
    Location:448530
    Fork_head_N; Forkhead N-terminal region
  2. XM_006522002.1XP_006522065.1  

    Conserved Domains (2) summary
    cd08367
    Location:177358
    P53; P53 DNA-binding domain
    pfam07710
    Location:397432
    P53_tetramer; P53 tetramerization motif
  3. XM_006522001.2XP_006522064.1  

    Conserved Domains (5) summary
    cd08367
    Location:58239
    P53; P53 DNA-binding domain
    cd09572
    Location:424488
    SAM_tumor-p63; SAM domain of tumor-p63 proteins
    smart00454
    Location:422487
    SAM; Sterile alpha motif
    pfam07710
    Location:278313
    P53_tetramer; P53 tetramerization motif
    pfam08430
    Location:333415
    Fork_head_N; Forkhead N-terminal region

Alternate Mm_Celera

Genomic

  1. AC_000038.1 Alternate Mm_Celera

    Range
    26227614..26435704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)