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    IGF2BP1 insulin like growth factor 2 mRNA binding protein 1 [ Homo sapiens (human) ]

    Gene ID: 10642, updated on 3-Apr-2016
    Official Symbol
    IGF2BP1provided by HGNC
    Official Full Name
    insulin like growth factor 2 mRNA binding protein 1provided by HGNC
    Primary source
    HGNC:HGNC:28866
    See related
    Ensembl:ENSG00000159217 HPRD:09752; MIM:608288; Vega:OTTHUMG00000161173
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1
    Summary
    This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
    Orthologs
    Location:
    17q21.32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 17 NC_000017.11 (48997412..49056145)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (47074774..47133507)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene gastric inhibitory polypeptide Neighboring gene uncharacterized LOC105371815 Neighboring gene beta-1,4-N-acetyl-galactosaminyltransferase 2 Neighboring gene ribosomal protein S10 pseudogene 25 Neighboring gene transfer RNA-Gln (TTG) 1-1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.
    NHGRI GWA Catalog
    Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.
    NHGRI GWA Catalog
    Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify insulin-like growth factor 2 Mrna binding protein 1 (IGF2BP1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Expression of IMP1 protein decreases HIV-1 infectivity, inhibits viral RNA packaging, and impedes the assembly and processing of Gag on cellular membrane PubMed
    gag Gag-IMP1 interaction requires the second zinc finger of the NC domain (residues 390-449) of Gag and the KH3 (residues 409-458) and KH4 (residues 490-540) domains of IMP1 PubMed
    gag IMP1 co-localizes with HIV-1 Gag in cells and is packaged into virus particles via its interaction with HIV-1 Gag PubMed
    Rev rev IMP1 interacts with HIV-1 Rev and has the ability of relocating Rev from the nucleus to the cytoplasm PubMed
    nucleocapsid gag Gag-IMP1 interaction requires the second zinc finger of the NC domain (residues 390-449) of Gag and the KH3 (residues 409-458) and KH4 (residues 490-540) domains of IMP1 PubMed

    Go to the HIV-1, Human Interaction Database

    • BDNF signaling pathway, organism-specific biosystem (from WikiPathways)
      BDNF signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, organism-specific biosystem (from REACTOME)
      Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, organism-specific biosystemInsulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs) bind specific sets of RNA and regulate their translation, stability, and subcellular localization. IGF2BP1, IGF2BP2, and IGF2BP3 bind abou...
    • MAPK family signaling cascades, organism-specific biosystem (from REACTOME)
      MAPK family signaling cascades, organism-specific biosystemThe mitogen activated protein kinases (MAPKs) are a family of conserved protein serine threonine kinases that respond to varied extracellular stimuli to activate intracellular processes including gen...
    • MAPK6/MAPK4 signaling, organism-specific biosystem (from REACTOME)
      MAPK6/MAPK4 signaling, organism-specific biosystemMAPK6 and MAPK4 (also known as ERK3 and ERK4) are vertebrate-specific atypical MAP kinases. Atypical MAPK are less well characterized than their conventional counterparts, and are generally classifi...
    • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
      MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • MicroRNAs in cancer, conserved biosystem (from KEGG)
      MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
    • Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem (from Pathway Interaction Database)
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription, organism-specific biosystem
      Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    mRNA 3'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    translation regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    CRD-mediated mRNA stabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    gene expression TAS
    Traceable Author Statement
    more info
     
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    pallium cell proliferation in forebrain IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cytokine biosynthetic process IC
    Inferred by Curator
    more info
    PubMed 
    regulation of mRNA stability involved in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    CRD-mediated mRNA stability complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon IEA
    Inferred from Electronic Annotation
    more info
     
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    dendritic spine IEA
    Inferred from Electronic Annotation
    more info
     
    filopodium IEA
    Inferred from Electronic Annotation
    more info
     
    growth cone IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular ribonucleoprotein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    insulin-like growth factor 2 mRNA-binding protein 1
    Names
    IGF-II mRNA-binding protein 1
    IGF2 mRNA-binding protein 1
    VICKZ family member 1
    ZBP-1
    coding region determinant-binding protein
    insulin-like growth factor 2 mRNA binding protein 1 deltaN CRDBP
    zipcode-binding protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030585.1 RefSeqGene

      Range
      5001..63734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001160423.1NP_001153895.1  insulin-like growth factor 2 mRNA-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001153895.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC105030, DA758608, DQ227344
      Consensus CDS
      CCDS54138.1
      UniProtKB/Swiss-Prot
      Q9NZI8
      Related
      ENSP00000389135, OTTHUMP00000219841, ENST00000431824, OTTHUMT00000364047
      Conserved Domains (4) summary
      smart00360
      Location:370
      RRM; RNA recognition motif
      cd00105
      Location:140205
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd12625
      Location:177
      RRM1_IGF2BP1; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
      cl17169
      Location:81135
      RRM_SF; RNA recognition motif (RRM) superfamily
    2. NM_006546.3NP_006537.3  insulin-like growth factor 2 mRNA-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_006537.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC105030, AF198254, AK074915, BP238821
      Consensus CDS
      CCDS11543.1
      UniProtKB/Swiss-Prot
      Q9NZI8
      Related
      ENSP00000290341, OTTHUMP00000219840, ENST00000290341, OTTHUMT00000364046
      Conserved Domains (4) summary
      smart00360
      Location:370
      RRM; RNA recognition motif
      cd00105
      Location:279344
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd12625
      Location:177
      RRM1_IGF2BP1; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
      cd12628
      Location:81156
      RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p2 Primary Assembly

      Range
      48997412..49056145
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524201.1XP_011522503.1  

      See identical proteins and their annotated locations for XP_011522503.1

      Conserved Domains (4) summary
      smart00360
      Location:370
      RRM; RNA recognition motif
      cd00105
      Location:279344
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd12625
      Location:177
      RRM1_IGF2BP1; RNA recognition motif 1 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
      cd12628
      Location:81156
      RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)
    2. XM_005256955.2XP_005257012.2  

      Conserved Domains (3) summary
      smart00360
      Location:70139
      RRM; RNA recognition motif
      cd00105
      Location:267332
      KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
      cd12628
      Location:69144
      RRM2_IGF2BP1; RNA recognition motif 2 in vertebrate insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

    Alternate CHM1_1.1

    Genomic

    1. NC_018928.2 Alternate CHM1_1.1

      Range
      47140077..47198718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)