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Tnfrsf25 tumor necrosis factor receptor superfamily, member 25 [ Mus musculus (house mouse) ]

Gene ID: 85030, updated on 24-Jan-2015
Official Symbol
Tnfrsf25provided by MGI
Official Full Name
tumor necrosis factor receptor superfamily, member 25provided by MGI
Primary source
MGI:MGI:1934667
Locus tag
RP23-284C20.2
See related
Ensembl:ENSMUSG00000024793; Vega:OTTMUSG00000010224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DR3; TR3; Wsl; DDR3; LARD; APO-3; TRAMP; WSL-1; WSL-LR; Tnfrsf12
Orthologs
See Tnfrsf25 in MapViewer
Location:
4; 4 E1
Exon count:
10
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 4 NC_000070.6 (152115934..152120111)

Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene nucleolar protein 9 Neighboring gene pleckstrin homology domain containing, family G (with RhoGef domain) member 5 Neighboring gene espin Neighboring gene espin-like pseudogene Neighboring gene predicted gene, 20377

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
Preferred Names
tumor necrosis factor receptor superfamily member 25
Names
tumor necrosis factor receptor superfamily member 25
tumor necrosis factor receptor superfamily, member 12

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291010.1NP_001277939.1  tumor necrosis factor receptor superfamily member 25 isoform 1 precursor

    See proteins identical to NP_001277939.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL772240
    Consensus CDS
    CCDS71527.1
    UniProtKB/TrEMBL
    B1AWN9
    Conserved Domains (2) summary
    cd00185
    Location:49146
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    cl14633
    Location:328404
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. NM_033042.4NP_149031.2  tumor necrosis factor receptor superfamily member 25 isoform 2 precursor

    See proteins identical to NP_149031.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon and lacks two consecutive exons in the 5' coding region, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL772240
    Consensus CDS
    CCDS38983.1
    UniProtKB/TrEMBL
    Q8VD70
    Related
    ENSMUSP00000047823, OTTMUSP00000010995, ENSMUST00000035275, OTTMUST00000023979
    Conserved Domains (2) summary
    cd00185
    Location:53159
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    cl14633
    Location:304380
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000070.6 

    Range
    152115934..152120111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539320.1XP_006539383.1  

    Related
    ENSMUSP00000025706, OTTMUSP00000010872, ENSMUST00000025706, OTTMUST00000023754
    Conserved Domains (2) summary
    cd00185
    Location:49146
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    cl14633
    Location:328404
    DD; Death Domain Superfamily of protein-protein interaction domains
  2. XM_006539319.1XP_006539382.1  

    Conserved Domains (2) summary
    cd00185
    Location:66153
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    cl14633
    Location:335411
    DD; Death Domain Superfamily of protein-protein interaction domains
  3. XM_006539318.1XP_006539381.1  

    Conserved Domains (2) summary
    cd00185
    Location:53159
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
    cl14633
    Location:341417
    DD; Death Domain Superfamily of protein-protein interaction domains
  4. XM_006539323.1XP_006539386.1  

    Conserved Domains (1) summary
    cd00185
    Location:53159
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  5. XM_006539324.1XP_006539387.1  

    Conserved Domains (1) summary
    cd00185
    Location:53159
    TNFR; Tumor necrosis factor receptor (TNFR) domain; superfamily of TNF-like receptor domains. When bound to TNF-like cytokines, TNFRs trigger multiple signal transduction pathways, they are involved in inflammation response, apoptosis, autoimmunity and ...
  6. XM_006539321.1XP_006539384.1  

    Conserved Domains (1) summary
    cl14633
    Location:177253
    DD; Death Domain Superfamily of protein-protein interaction domains
  7. XM_006539322.1XP_006539385.1  

    Conserved Domains (1) summary
    cl14633
    Location:157233
    DD; Death Domain Superfamily of protein-protein interaction domains

Alternate Mm_Celera

Genomic

  1. AC_000026.1 

    Range
    154402873..154406641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)