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    FBXL5 F-box and leucine rich repeat protein 5 [ Homo sapiens (human) ]

    Gene ID: 26234, updated on 12-Jun-2016
    Official Symbol
    FBXL5provided by HGNC
    Official Full Name
    F-box and leucine rich repeat protein 5provided by HGNC
    Primary source
    HGNC:HGNC:13602
    See related
    Ensembl:ENSG00000118564 HPRD:05739; MIM:605655; Vega:OTTHUMG00000097097
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FBL4; FBL5; FLR1
    Summary
    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
    Orthologs
    Location:
    4p15.32
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 4 NC_000004.12 (15604384..15681545, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (15606007..15661487, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986185 Neighboring gene coiled-coil and C2 domain containing 2A Neighboring gene family with sequence similarity 200 member B Neighboring gene bone marrow stromal cell antigen 1 Neighboring gene ribosomal protein L10a pseudogene 7

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystem (from REACTOME)
      Association of TriC/CCT with target proteins during biosynthesis, organism-specific biosystemTRiC has broad recognition specificities, but in the cell it interacts with only a defined set of substrates (Yam et al. 2008). Many of its substrates that are targeted during biosynthesis are conse...
    • Chaperonin-mediated protein folding, organism-specific biosystem (from REACTOME)
      Chaperonin-mediated protein folding, organism-specific biosystemThe eukaryotic chaperonin TCP-1 ring complex (TRiC/ CCT) plays an essential role in the folding of a subset of proteins prominent among which are the actins and tubulins (reviewed in Altschuler and...
    • Metabolism of proteins, organism-specific biosystem (from REACTOME)
      Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
    • Protein folding, organism-specific biosystem (from REACTOME)
      Protein folding, organism-specific biosystemDue to the crowded envirnoment within the cell, many proteins must interact with molecular chaperones to attain their native conformation (reviewed in Young et al., 2004). Chaperones recognize and...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    iron ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    iron ion homeostasis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    iron ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cellular protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    protein ubiquitination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Preferred Names
    F-box/LRR-repeat protein 5
    Names
    F-box and leucine-rich repeat protein 5
    F-box protein FBL4/FBL5
    p45SKP2-like protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047143.1 RefSeqGene

      Range
      9506..60534
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193534.1NP_001180463.1  F-box/LRR-repeat protein 5 isoform 3

      See identical proteins and their annotated locations for NP_001180463.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC116651, AF142481, AF199420, AI858616, BC030656, BF432189, DB080171
      UniProtKB/Swiss-Prot
      Q9UKA1
      Conserved Domains (4) summary
      cd09293
      Location:353407
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7160
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      pfam12937
      Location:204248
      F-box-like; F-box-like
      sd00034
      Location:331356
      LRR_AMN1; leucine-rich repeat [structural motif]
    2. NM_001193535.1NP_001180464.1  F-box/LRR-repeat protein 5 isoform 4

      See identical proteins and their annotated locations for NP_001180464.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AC116651, AI858616, BC030656, BF432189, BX537957, DB080171
      Consensus CDS
      CCDS54745.1
      UniProtKB/Swiss-Prot
      Q9UKA1
      Related
      ENSP00000408679, OTTHUMP00000217784, ENST00000412094, OTTHUMT00000359678
      Conserved Domains (4) summary
      cd09293
      Location:337391
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7143
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      pfam12937
      Location:188232
      F-box-like; F-box-like
      sd00034
      Location:315340
      LRR_AMN1; leucine-rich repeat [structural motif]
    3. NM_012161.3NP_036293.1  F-box/LRR-repeat protein 5 isoform 1

      See identical proteins and their annotated locations for NP_036293.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC116651, AF142481, AI858616, BC030656, BF432189, DB080171
      Consensus CDS
      CCDS3415.1
      UniProtKB/Swiss-Prot
      Q9UKA1
      Related
      ENSP00000344866, OTTHUMP00000122631, ENST00000341285, OTTHUMT00000214235
      Conserved Domains (4) summary
      cd09293
      Location:354408
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:7160
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      pfam12937
      Location:205249
      F-box-like; F-box-like
      sd00034
      Location:332357
      LRR_AMN1; leucine-rich repeat [structural motif]

    RNA

    1. NR_036464.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC116651, AI858616, BC012320, BC030656, BF432189, DB080171
      Related
      ENST00000511441, OTTHUMT00000359680

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p7 Primary Assembly

      Range
      15604384..15681545 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017008019.1XP_016863508.1  

    2. XM_006713959.3XP_006714022.1  

      Conserved Domains (4) summary
      cd09293
      Location:335389
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:10141
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      pfam12937
      Location:186230
      F-box-like; F-box-like
      sd00034
      Location:313338
      LRR_AMN1; leucine-rich repeat [structural motif]
    3. XM_011513832.2XP_011512134.1  

      Related
      ENSP00000425472, OTTHUMP00000217786, ENST00000513163, OTTHUMT00000359681
      Conserved Domains (4) summary
      cd09293
      Location:299353
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:1105
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      pfam12937
      Location:150194
      F-box-like; F-box-like
      sd00034
      Location:277302
      LRR_AMN1; leucine-rich repeat [structural motif]
    4. XM_011513831.2XP_011512133.1  

      Conserved Domains (4) summary
      cd09293
      Location:318372
      AMN1; Antagonist of mitotic exit network protein 1
      cd12109
      Location:9124
      Hr_FBXL5; Hemerythrin-like domain of FBXL5-like proteins
      pfam12937
      Location:169213
      F-box-like; F-box-like
      sd00034
      Location:296321
      LRR_AMN1; leucine-rich repeat [structural motif]
    5. XM_011513833.2XP_011512135.1  

      Conserved Domains (5) summary
      cd09293
      Location:282336
      AMN1; Antagonist of mitotic exit network protein 1
      pfam12937
      Location:133177
      F-box-like; F-box-like
      pfam13855
      Location:283321
      LRR_8; Leucine rich repeat
      sd00034
      Location:260285
      LRR_AMN1; leucine-rich repeat [structural motif]
      cl15774
      Location:2088
      Hemerythrin-like; Hemerythrin family

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      15603953..15655030 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)