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    Il1r1 interleukin 1 receptor, type I [ Mus musculus (house mouse) ]

    Gene ID: 16177, updated on 10-Sep-2016
    Official Symbol
    Il1r1provided by MGI
    Official Full Name
    interleukin 1 receptor, type Iprovided by MGI
    Primary source
    MGI:MGI:96545
    See related
    Ensembl:ENSMUSG00000026072 Vega:OTTMUSG00000050518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    IL-iR; CD121a; CD121b; IL-1R1; Il1r-1
    Orthologs
    Location:
    1 B; 1 18.81 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (40225014..40316201)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (40281925..40373022)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 16894 Neighboring gene interleukin 1 receptor, type II Neighboring gene predicted gene, 35741 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene interleukin 1 receptor-like 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    • Amoebiasis, organism-specific biosystem (from KEGG)
      Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Amoebiasis, conserved biosystem (from KEGG)
      Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
    • Apoptosis signaling pathway, organism-specific biosystem (from LIPID MAPS)
      Apoptosis signaling pathway, organism-specific biosystem
      Apoptosis signaling pathway
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • HTLV-I infection, organism-specific biosystem (from KEGG)
      HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • HTLV-I infection, conserved biosystem (from KEGG)
      HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
    • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
      Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hematopoietic cell lineage, conserved biosystem (from KEGG)
      Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
    • Hypertrophy Model, organism-specific biosystem (from WikiPathways)
      Hypertrophy Model, organism-specific biosystem
      Hypertrophy Model
    • IL-1 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-1 Signaling Pathway, organism-specific biosystemThe interleukin 1 family of cytokines includes interleukin-1 alpha (IL1A), beta (IL1B) and the IL-1 receptor antagonist (IL1RN). These bind to the IL-1 receptor (IL1R1) as well as its decoy receptor,...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
      Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
    • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
      Interleukin-1 signaling, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, organism-specific biosystem (from KEGG)
      MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • MAPK signaling pathway, conserved biosystem (from KEGG)
      MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
    • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
      NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
      NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
    • Osteoclast differentiation, organism-specific biosystem (from KEGG)
      Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Osteoclast differentiation, conserved biosystem (from KEGG)
      Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
      Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC129154

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    interleukin-1 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    interleukin-1 receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    interleukin-1 receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interleukin-1 receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1, Type I, activating receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    ionotropic glutamate receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    platelet-derived growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    signal transducer activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    cytokine-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    heat acclimation ISO
    Inferred from Sequence Orthology
    more info
     
    interleukin-1-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of interleukin-1-mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neutrophil extravasation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of inflammatory response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to interleukin-1 ISO
    Inferred from Sequence Orthology
    more info
     
    response to radiation ISO
    Inferred from Sequence Orthology
    more info
     
    signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
     
    protein complex ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    interleukin-1 receptor type 1
    Names
    CD121 antigen-like family member A
    IL-1 receptor alpha chain
    IL-1R-1
    IL-1R-alpha
    IL-1RT-1
    IL-1RT1
    interleukin-1 receptor alpha
    p80

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123382.1NP_001116854.1  interleukin-1 receptor type 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001116854.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains a different segment for its 5' UTR and 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.
      Source sequence(s)
      AC167168, AK054137
      Consensus CDS
      CCDS48246.1
      UniProtKB/TrEMBL
      Q8C6P3, Q8C833
      Related
      ENSMUSP00000110443, OTTMUSP00000068976, ENSMUST00000114795, OTTMUST00000128133
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    2. NM_008362.2NP_032388.1  interleukin-1 receptor type 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_032388.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC167168, M20658
      Consensus CDS
      CCDS35547.1
      UniProtKB/Swiss-Prot
      P13504
      UniProtKB/TrEMBL
      Q32MH0
      Related
      ENSMUSP00000027241, OTTMUSP00000068975, ENSMUST00000027241, OTTMUST00000128132
      Conserved Domains (5) summary
      cd05757
      Location:131222
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:387542
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:237331
      IG_like; Immunoglobulin like
      pfam13927
      Location:228319
      Ig_3; Immunoglobulin domain
      cl11960
      Location:31116
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      40225014..40316201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006495713.2XP_006495776.1  

      See identical proteins and their annotated locations for XP_006495776.1

      UniProtKB/Swiss-Prot
      P13504
      UniProtKB/TrEMBL
      Q32MH0
      Conserved Domains (5) summary
      cd05757
      Location:131222
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:387542
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:237331
      IG_like; Immunoglobulin like
      pfam13927
      Location:228319
      Ig_3; Immunoglobulin domain
      cl11960
      Location:31116
      Ig; Immunoglobulin domain
    2. XM_006495719.2XP_006495782.1  

      See identical proteins and their annotated locations for XP_006495782.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    3. XM_006495722.2XP_006495785.1  

      See identical proteins and their annotated locations for XP_006495785.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    4. XM_017317595.1XP_017173084.1  

      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    5. XM_017317613.1XP_017173102.1  

      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    6. XM_006495723.3XP_006495786.1  

      See identical proteins and their annotated locations for XP_006495786.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    7. XM_006495721.3XP_006495784.1  

      See identical proteins and their annotated locations for XP_006495784.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    8. XM_011238436.2XP_011236738.1  

      See identical proteins and their annotated locations for XP_011236738.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    9. XM_006495715.3XP_006495778.1  

      See identical proteins and their annotated locations for XP_006495778.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    10. XM_006495720.3XP_006495783.1  

      See identical proteins and their annotated locations for XP_006495783.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    11. XM_006495714.3XP_006495777.1  

      See identical proteins and their annotated locations for XP_006495777.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
    12. XM_006495717.2XP_006495780.1  

      See identical proteins and their annotated locations for XP_006495780.1

      UniProtKB/TrEMBL
      Q8C833
      Conserved Domains (5) summary
      cd05757
      Location:128219
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00255
      Location:384539
      TIR; Toll - interleukin 1 - resistance
      smart00410
      Location:234328
      IG_like; Immunoglobulin like
      pfam13927
      Location:225316
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28113
      Ig; Immunoglobulin domain
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