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    CCR3 chemokine (C-C motif) receptor 3 [ Homo sapiens (human) ]

    Gene ID: 1232, updated on 24-Aug-2015
    Official Symbol
    CCR3provided by HGNC
    Official Full Name
    chemokine (C-C motif) receptor 3provided by HGNC
    Primary source
    HGNC:HGNC:1604
    See related
    Ensembl:ENSG00000183625; HPRD:03167; MIM:601268; Vega:OTTHUMG00000133484
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CKR3; CD193; CMKBR3; CC-CKR-3
    Summary
    The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]
    Orthologs
    See CCR3 in Epigenomics, MapViewer
    Location:
    3p21.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 3 NC_000003.12 (46210695..46266706)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (46283872..46308197)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377067 Neighboring gene fms-related tyrosine kinase 1 pseudogene 1 Neighboring gene chemokine (C-C motif) receptor 1 Neighboring gene ubiquinol-cytochrome c reductase core protein II pseudogene 1 Neighboring gene chemokine (C-C motif) receptor 2

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    NHGRI GWAS Catalog

    Description
    Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
    NHGRI GWA Catalog
    Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children.
    NHGRI GWA Catalog
    Genome-wide association study of celiac disease in North America confirms FRMD4B as new celiac locus.
    NHGRI GWA Catalog
    Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation.
    NHGRI GWA Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    NHGRI GWA Catalog
    Newly identified genetic risk variants for celiac disease related to the immune response.
    NHGRI GWA Catalog
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env The coreceptor-binding site in HIV-1 gp120 is centered around an anti-parallel beta-sheet structure ?bridging sheet domain?; mutations in and adjacent to this domain affect the use of coreceptors CCR3 and CCR8 by gp120 for virus entry PubMed
    env CCR3 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor PubMed
    env HIV-1 gp120 utilization of CCR3 as a coreceptor facilitates infection by a more restricted subset of primary viruses, and binding of the CCR3 ligand, eotaxin, inhibits infection by these isolates PubMed
    env Utilization of CCR3 and CCR5 as coreceptors of HIV-1 binding/fusion depends upon the sequence of the third variable (V3) region of the HIV-1 gp120 exterior envelope glycoprotein PubMed
    env Macrophage-tropic HIV-1 can use CCR2b, and to a lesser extent CCR3, STRL33, and APJ, to infect cells; the V1/2 region of HIV-1 gp120 plays a more important role in governing the use of CCR2b, CCR3, STRL33, and APJ than for CXCR4 PubMed
    env Amino acid N356 in conserved region 3 of HIV-1 gp120 and amino acids R440 and N448 in conserved region 4 of gp120 are three amino-acid determinants for CCR3 use as a coreceptor for HIV-1 entry into cells PubMed
    env HIV-1 isolates showing CCR3 tropism are particularly efficient in using CMKLR1/ChemR23 as a co-receptor; some HIV-2 and SIV isolates also use CMKLR1/ChemR23 PubMed
    Envelope transmembrane glycoprotein gp41 env CCR3 is an alternative coreceptor usage by R5-tropic HIV-1 type C gp120/gp41, although its usage frequency is less than that of CCR5 coreceptor PubMed
    Nef nef HIV-1 Nef induces variable levels of CCR3 downregulation in different cell types PubMed
    Tat tat HIV-1 Tat-mediated activation of the CB2R leads to altered expression and compartmentation of the beta-chemokine receptor CCR-3 PubMed
    tat HIV-1 Tat-induced platelet activation requires the chemokine receptor CCR3 and beta3-integrin expression on platelets and calcium flux in platelets PubMed
    tat HIV-1 Tat binds to CCR3 and displaces MCP-3 from this beta-chemokine receptor, an effect mediated by Tat amino acids 24-51 PubMed
    tat HIV-1 Tat upregulates CCR3 expression on monocytes/macrophages, Fc epsilonRI+ cells and blood brain barrier cultures, and acts as a potent chemoattractant, indicating a role for Tat in HIV-1 pathogenesis and in promoting HIV-1 infectivity PubMed

    Go to the HIV-1, Human Interaction Database

    • Chemokine receptors bind chemokines, organism-specific biosystem (from REACTOME)
      Chemokine receptors bind chemokines, organism-specific biosystemChemokine receptors are cytokine receptors found on the surface of certain cells, which interact with a type of cytokine called a chemokine. Following interaction, these receptors trigger a flux of i...
    • Chemokine signaling pathway, organism-specific biosystem (from KEGG)
      Chemokine signaling pathway, organism-specific biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Chemokine signaling pathway, conserved biosystem (from KEGG)
      Chemokine signaling pathway, conserved biosystemInflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for th...
    • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
      Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
      G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
    • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
      GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
    • GPCR ligand binding, organism-specific biosystem (from REACTOME)
      GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
    • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
      GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
    • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
      Peptide GPCRs, organism-specific biosystem
      Peptide GPCRs
    • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
      Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
    • Signal Transduction, organism-specific biosystem (from REACTOME)
      Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
    • Signaling by GPCR, organism-specific biosystem (from REACTOME)
      Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
    • Viral carcinogenesis, organism-specific biosystem (from KEGG)
      Viral carcinogenesis, organism-specific biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    • Viral carcinogenesis, conserved biosystem (from KEGG)
      Viral carcinogenesis, conserved biosystemThere is a strong association between viruses and the development of human malignancies. We now know that at least six human viruses, Epstein-Barr virus (EBV), hepatitis B virus (HBV), hepatitis C vi...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC102841

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    C-C chemokine receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    cell adhesion TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular defense response TAS
    Traceable Author Statement
    more info
    PubMed 
    chemokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    chemokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    chemotaxis IEA
    Inferred from Electronic Annotation
    more info
     
    inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration TAS
    Traceable Author Statement
    more info
    PubMed 
    positive regulation of endothelial cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    viral process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol TAS
    Traceable Author Statement
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    C-C chemokine receptor type 3
    Names
    C-C CKR-3
    CC chemokine receptor 3
    CCR-3
    b-chemokine receptor
    eosinophil CC chemokine receptor 3
    eosinophil eotaxin receptor

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164680.1NP_001158152.1  C-C chemokine receptor type 3 isoform 3

      See identical proteins and their annotated locations for NP_001158152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate internal exon, which includes an upstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (3) has a longer N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC104439, AF262303
      UniProtKB/TrEMBL
      Q8TDP4
      Conserved Domains (1) summary
      pfam00001
      Location:75319
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. NM_001837.3NP_001828.1  C-C chemokine receptor type 3 isoform 1

      See identical proteins and their annotated locations for NP_001828.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. It encodes the same isoform (1) as variant 2.
      Source sequence(s)
      AC104439, AF262302
      Consensus CDS
      CCDS2738.1
      UniProtKB/TrEMBL
      A0A024R2Z3
      UniProtKB/Swiss-Prot
      P51677
      UniProtKB/TrEMBL
      Q8TDP5
      Conserved Domains (1) summary
      pfam00001
      Location:57301
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. NM_178328.1NP_847898.1  C-C chemokine receptor type 3 isoform 2

      See identical proteins and their annotated locations for NP_847898.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an alternate internal exon, which includes an upstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) has a longer N-terminus, as compared to isoform 1.
      Source sequence(s)
      AC104439, AF262301
      Consensus CDS
      CCDS54574.1
      UniProtKB/Swiss-Prot
      P51677
      Related
      ENSP00000441600, ENST00000545097
      Conserved Domains (1) summary
      pfam00001
      Location:78322
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    4. NM_178329.2NP_847899.1  C-C chemokine receptor type 3 isoform 1

      See identical proteins and their annotated locations for NP_847899.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, as compared to variant 1. Both variants encode the same isoform 1.
      Source sequence(s)
      AC104439, BC130320
      Consensus CDS
      CCDS2738.1
      UniProtKB/TrEMBL
      A0A024R2Z3
      UniProtKB/Swiss-Prot
      P51677
      Related
      ENSP00000379271, OTTHUMP00000209745, ENST00000395940, OTTHUMT00000343882
      Conserved Domains (1) summary
      pfam00001
      Location:57301
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p2 Primary Assembly

      Range
      46210695..46266706
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011533335.1XP_011531637.1  

      See identical proteins and their annotated locations for XP_011531637.1

      UniProtKB/TrEMBL
      A0A024R2Z3
      UniProtKB/Swiss-Prot
      P51677
      Conserved Domains (1) summary
      pfam00001
      Location:57301
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    2. XM_011533334.1XP_011531636.1  

      See identical proteins and their annotated locations for XP_011531636.1

      UniProtKB/Swiss-Prot
      P51677
      Conserved Domains (1) summary
      pfam00001
      Location:78322
      7tm_1; 7 transmembrane receptor (rhodopsin family)
    3. XM_006712960.2XP_006713023.1  

      See identical proteins and their annotated locations for XP_006713023.1

      UniProtKB/TrEMBL
      A0A024R2Z3
      UniProtKB/Swiss-Prot
      P51677
      Related
      ENSP00000350003, OTTHUMP00000164718, ENST00000357422, OTTHUMT00000257380
      Conserved Domains (1) summary
      pfam00001
      Location:57301
      7tm_1; 7 transmembrane receptor (rhodopsin family)

    Alternate CHM1_1.1

    Genomic

    1. NC_018914.2 Alternate CHM1_1.1

      Range
      46233878..46258185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)