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Cth cystathionase (cystathionine gamma-lyase) [ Mus musculus (house mouse) ]

Gene ID: 107869, updated on 11-Sep-2014
Official Symbol
Cthprovided by MGI
Official Full Name
cystathionase (cystathionine gamma-lyase)provided by MGI
Primary source
MGI:1339968
See related
Ensembl:ENSMUSG00000028179; Vega:OTTMUSG00000029713
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CSE; Cys3; AI314617; BC019483; 0610010I13Rik
Location:
3 H4; 3
Exon count:
12
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 3 NC_000069.6 (157894248..157925081, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene predicted gene 5550 Neighboring gene predicted gene 6520 Neighboring gene RIKEN cDNA 1810013D15 gene Neighboring gene ankyrin repeat domain 13c Neighboring gene uncharacterized LOC102636783

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Clone Names

  • MGC28655

Gene Ontology Provided by MGI

Function Evidence Code Pubs
L-cysteine desulfhydrase activity IEA
Inferred from Electronic Annotation
more info
 
L-cystine L-cysteine-lyase (deaminating) IDA
Inferred from Direct Assay
more info
 
L-cystine L-cysteine-lyase (deaminating) IMP
Inferred from Mutant Phenotype
more info
PubMed 
L-cystine L-cysteine-lyase (deaminating) ISO
Inferred from Sequence Orthology
more info
 
calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
cystathionine beta-lyase activity ISO
Inferred from Sequence Orthology
more info
 
cystathionine gamma-lyase activity IDA
Inferred from Direct Assay
more info
PubMed 
cystathionine gamma-lyase activity ISO
Inferred from Sequence Orthology
more info
 
lyase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
pyridoxal phosphate binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cellular amino acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cysteine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
homocysteine metabolic process ISO
Inferred from Sequence Orthology
more info
 
hydrogen sulfide biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 
protein homotetramerization ISO
Inferred from Sequence Orthology
more info
 
protein sulfhydration IDA
Inferred from Direct Assay
more info
 
protein sulfhydration IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein sulfhydration ISO
Inferred from Sequence Orthology
more info
 
protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
cystathionine gamma-lyase
Names
cystathionine gamma-lyase
gamma-cystathionase
cysteine-protein sulfhydrase
NP_666065.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145953.2NP_666065.1  cystathionine gamma-lyase

    See proteins identical to NP_666065.1

    Status: PROVISIONAL

    Source sequence(s)
    AY083352
    Consensus CDS
    CCDS51101.1
    UniProtKB/Swiss-Prot
    Q8VCN5
    Related
    ENSMUSP00000113672, OTTMUSP00000038207, ENSMUST00000118539, OTTMUST00000073720
    Conserved Domains (1) summary
    cd00614
    Location:35394
    Blast Score: 1429
    CGS_like; CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000069.6 

    Range
    157894248..157925081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500815.1XP_006500878.1  

    Conserved Domains (1) summary
    cd00614
    Location:56298
    Blast Score: 1042
    CGS_like; CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of ...

Alternate Mm_Celera

Genomic

  1. AC_000025.1 

    Range
    164361761..164392686
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)