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Ghr growth hormone receptor [ Mus musculus (house mouse) ]

Gene ID: 14600, updated on 24-Dec-2014
Official Symbol
Ghrprovided by MGI
Official Full Name
growth hormone receptorprovided by MGI
Primary source
MGI:MGI:95708
See related
Ensembl:ENSMUSG00000055737; Vega:OTTMUSG00000030599
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GHBP; GHR/BP
Location:
15 A1; 15 1.84 cM
Exon count:
17
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 15 NC_000081.6 (3317755..3583352, complement)

Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 30057 Neighboring gene coiled-coil domain containing 152 Neighboring gene selenoprotein P, plasma, 1 Neighboring gene mediator complex subunit 27 pseudogene Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH2 domain binding ISO
Inferred from Sequence Orthology
more info
 
cytokine receptor activity IEA
Inferred from Electronic Annotation
more info
 
growth factor binding ISO
Inferred from Sequence Orthology
more info
 
growth hormone receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
growth hormone receptor activity ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
2-oxoglutarate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
activation of JAK2 kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
activation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
allantoin metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
citrate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
creatine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
creatinine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
endocytosis IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth hormone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
growth hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
hormone-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
insulin-like growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
isoleucine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organismal metabolic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
oxaloacetate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of JAK-STAT cascade ISO
Inferred from Sequence Orthology
more info
 
positive regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of multicellular organism growth IDA
Inferred from Direct Assay
more info
PubMed 
response to estradiol ISO
Inferred from Sequence Orthology
more info
 
succinate metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
taurine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
valine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
extrinsic component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
growth hormone receptor complex ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
growth hormone receptor
Names
growth hormone receptor
GH receptor
somatotropin receptor
growth hormone receptor/binding protein
Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001048178.2NP_001041643.1  growth hormone receptor isoform 2 precursor

    See proteins identical to NP_001041643.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and uses an alternate 3'-terminal exon, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC113323, AC121307, AK143925, AK148440
    Consensus CDS
    CCDS37024.1
    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UNY8
    Related
    ENSMUSP00000106326, OTTMUSP00000039788, ENSMUST00000110698, OTTMUST00000075776
    Conserved Domains (2) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09067
    Location:49135
    EpoR_lig-bind; Erythropoietin receptor, ligand binding
  2. NM_001286370.1NP_001273299.1  growth hormone receptor isoform 1 precursor

    See proteins identical to NP_001273299.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Both variants 1 and 4 encode the same isoform (1).
    Source sequence(s)
    AC166491, AK143886
    Consensus CDS
    CCDS27358.1
    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UP14
    Conserved Domains (3) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09067
    Location:49135
    EpoR_lig-bind; Erythropoietin receptor, ligand binding
    pfam12772
    Location:325634
    GHBP; Growth hormone receptor binding
  3. NM_010284.3NP_034414.2  growth hormone receptor isoform 1 precursor

    See proteins identical to NP_034414.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 4 encode the same isoform.
    Source sequence(s)
    AC113323, AC166491, AK143925, AK148440
    Consensus CDS
    CCDS27358.1
    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UNY8
    UniProtKB/TrEMBL
    Q3UP14
    Related
    ENSMUSP00000069457, OTTMUSP00000039789, ENSMUST00000069451, OTTMUST00000075779
    Conserved Domains (3) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09067
    Location:49135
    EpoR_lig-bind; Erythropoietin receptor, ligand binding
    pfam12772
    Location:325634
    GHBP; Growth hormone receptor binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000081.6 

    Range
    3317755..3583352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519963.1XP_006520026.1  

    See proteins identical to XP_006520026.1

    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UP14
    Conserved Domains (3) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09067
    Location:49135
    EpoR_lig-bind; Erythropoietin receptor, ligand binding
    pfam12772
    Location:325634
    GHBP; Growth hormone receptor binding
  2. XM_006519964.1XP_006520027.1  

    See proteins identical to XP_006520027.1

    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UP14
    Conserved Domains (3) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09067
    Location:49135
    EpoR_lig-bind; Erythropoietin receptor, ligand binding
    pfam12772
    Location:325634
    GHBP; Growth hormone receptor binding
  3. XM_006519965.1XP_006520028.1  

    See proteins identical to XP_006520028.1

    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UP14
    Conserved Domains (3) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09067
    Location:49135
    EpoR_lig-bind; Erythropoietin receptor, ligand binding
    pfam12772
    Location:325634
    GHBP; Growth hormone receptor binding
  4. XM_006519966.1XP_006520029.1  

    See proteins identical to XP_006520029.1

    UniProtKB/Swiss-Prot
    P16882
    UniProtKB/TrEMBL
    Q3UP14
    Conserved Domains (3) summary
    cd00063
    Location:157258
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam09067
    Location:49135
    EpoR_lig-bind; Erythropoietin receptor, ligand binding
    pfam12772
    Location:325634
    GHBP; Growth hormone receptor binding

Alternate Mm_Celera

Genomic

  1. AC_000037.1 

    Range
    3182316..3449004
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001048147.1: Suppressed sequence

    Description
    NM_001048147.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.