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    UGDH UDP-glucose 6-dehydrogenase [ Homo sapiens (human) ]

    Gene ID: 7358, updated on 14-Apr-2016
    Official Symbol
    UGDHprovided by HGNC
    Official Full Name
    UDP-glucose 6-dehydrogenaseprovided by HGNC
    Primary source
    HGNC:HGNC:12525
    See related
    Ensembl:ENSG00000109814 HPRD:04535; MIM:603370; Vega:OTTHUMG00000099371
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GDH; UGD; UDPGDH; UDP-GlcDH
    Summary
    The protein encoded by this gene converts UDP-glucose to UDP-glucuronate and thereby participates in the biosynthesis of glycosaminoglycans such as hyaluronan, chondroitin sulfate, and heparan sulfate. These glycosylated compounds are common components of the extracellular matrix and likely play roles in signal transduction, cell migration, and cancer growth and metastasis. The expression of this gene is up-regulated by transforming growth factor beta and down-regulated by hypoxia. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
    Orthologs
    Location:
    4p15.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (39498755..39527598, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (39500375..39529218, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene lipoic acid synthetase Neighboring gene WD repeat domain 5 pseudogene Neighboring gene UGDH antisense RNA 1 Neighboring gene small integral membrane protein 14 Neighboring gene RNA, U7 small nuclear 11 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    UDP-glucose 6-dehydrogenase activity TAS
    Traceable Author Statement
    more info
     
    electron carrier activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    UDP-glucose metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    UDP-glucuronate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    UDP-glucuronate biosynthetic process TAS
    Traceable Author Statement
    more info
     
    carbohydrate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    gastrulation with mouth forming second IEA
    Inferred from Electronic Annotation
    more info
     
    glycosaminoglycan biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    oxidation-reduction process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Preferred Names
    UDP-glucose 6-dehydrogenase
    Names
    UDP-Glc dehydrogenase
    UDP-glucose dehydrogenase
    uridine diphospho-glucose dehydrogenase
    NP_001171629.1
    NP_001171630.1
    NP_003350.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184700.1NP_001171629.1  UDP-glucose 6-dehydrogenase isoform 2

      See identical proteins and their annotated locations for NP_001171629.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AK097930, AL699883, AL708740, AU131705, BC022781, BG194936
      Consensus CDS
      CCDS54758.1
      UniProtKB/Swiss-Prot
      O60701
      Related
      ENSP00000422909, OTTHUMP00000218417, ENST00000501493, OTTHUMT00000361008
      Conserved Domains (4) summary
      PLN02353
      Location:4397
      PLN02353; probable UDP-glucose 6-dehydrogenase
      pfam00984
      Location:146243
      UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
      pfam03720
      Location:265379
      UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
      cl21454
      Location:5124
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001184701.1NP_001171630.1  UDP-glucose 6-dehydrogenase isoform 3

      See identical proteins and their annotated locations for NP_001171630.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 3 has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC021148, AK297737, AL708740, BC022781
      Consensus CDS
      CCDS54757.1
      UniProtKB/Swiss-Prot
      O60701
      Related
      ENSP00000426560, OTTHUMP00000218416, ENST00000507089, OTTHUMT00000361007
      Conserved Domains (3) summary
      pfam00984
      Location:116213
      UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
      pfam03720
      Location:235349
      UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
      cl21454
      Location:394
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_003359.3NP_003350.1  UDP-glucose 6-dehydrogenase isoform 1

      See identical proteins and their annotated locations for NP_003350.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC021148, AF061016, AJ007702
      Consensus CDS
      CCDS3455.1
      UniProtKB/Swiss-Prot
      O60701
      Related
      ENSP00000319501, OTTHUMP00000125211, ENST00000316423, OTTHUMT00000216818
      Conserved Domains (4) summary
      PLN02353
      Location:4464
      PLN02353; probable UDP-glucose 6-dehydrogenase
      pfam00984
      Location:213310
      UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
      pfam03720
      Location:332446
      UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
      pfam03721
      Location:5191
      UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

      Range
      39498755..39527598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005262667.2XP_005262724.1  

      Conserved Domains (4) summary
      PLN02353
      Location:17477
      PLN02353; probable UDP-glucose 6-dehydrogenase
      pfam00984
      Location:226323
      UDPG_MGDP_dh; UDP-glucose/GDP-mannose dehydrogenase family, central domain
      pfam03720
      Location:345459
      UDPG_MGDP_dh_C; UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain
      pfam03721
      Location:18204
      UDPG_MGDP_dh_N; UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018915.2 Alternate CHM1_1.1

      Range
      39499802..39528655 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)