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    IFNL3 interferon lambda 3 [ Homo sapiens (human) ]

    Gene ID: 282617, updated on 22-Aug-2016
    Official Symbol
    IFNL3provided by HGNC
    Official Full Name
    interferon lambda 3provided by HGNC
    Primary source
    HGNC:HGNC:18365
    See related
    Ensembl:ENSG00000197110 HPRD:09587; MIM:607402; Vega:OTTHUMG00000182805
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL28B; IL28C; IL-28B
    Summary
    This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    19q13.13
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (39243536..39245481, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (39734272..39735916, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene syncollin Neighboring gene uncharacterized LOC107985266 Neighboring gene interferon lambda 3 pseudogene 1 Neighboring gene interferon lambda 4 (gene/pseudogene) Neighboring gene methionine sulfoxide reductase B1 pseudogene 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Hepatitis c virus, susceptibility to
    MedGen: C1835407 OMIM: 609532 GeneReviews: Not available
    Compare labs
    Peginterferon alfa-2a response
    MedGen: CN184128 GeneReviews: Not available
    Compare labs
    Peginterferon alfa-2b response
    MedGen: CN078000 GeneReviews: Not available
    Compare labs
    Ribavirin response
    MedGen: CN184129 GeneReviews: Not available
    Compare labs
    Telaprevir response
    MedGen: CN078014 GeneReviews: Not available
    not available

    NHGRI GWAS Catalog

    Description
    Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.
    NHGRI GWA Catalog
    Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts.
    NHGRI GWA Catalog
    IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.
    NHGRI GWA Catalog
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
      Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
      Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
      Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
    • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
      Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
    • Type III interferon signaling, organism-specific biosystem (from WikiPathways)
      Type III interferon signaling, organism-specific biosystemThe recently identified type III interferon group consists of three IFN-? (lambda) genes encoding molecules called IFN-?1, IFN-?2 and IFN-?3 (also called IL29, IL28A and IL28B respectively). These IF...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    JAK-STAT cascade IEA
    Inferred from Electronic Annotation
    more info
     
    defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    defense response to virus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    negative regulation of viral genome replication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of immune response IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein targeting to mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    extracellular region TAS
    Traceable Author Statement
    more info
     
    extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    intracellular IEA
    Inferred from Electronic Annotation
    more info
     
    Preferred Names
    interferon lambda-3
    Names
    IFN-lambda-3
    IFN-lambda-4
    IL-28C
    cytokine Zcyto22
    interferon, lambda 3
    interferon, lambda 4
    interleukin-28B
    interleukin-28C

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042193.1 RefSeqGene

      Range
      5001..6340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_172139.2NP_742151.2  interferon lambda-3 precursor

      See identical proteins and their annotated locations for NP_742151.2

      Status: REVIEWED

      Source sequence(s)
      AY129149
      Consensus CDS
      CCDS12530.1
      UniProtKB/Swiss-Prot
      Q8IZI9
      Related
      ENSP00000409000, OTTHUMP00000270255, ENST00000413851, OTTHUMT00000463832
      Conserved Domains (1) summary
      pfam15177
      Location:32193
      IL28A; Interleukin-28A

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      39243536..39245481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005258765.4XP_005258822.1  

      See identical proteins and their annotated locations for XP_005258822.1

      UniProtKB/Swiss-Prot
      Q8IZI9
      UniProtKB/TrEMBL
      A0A0C4DGW8
      Related
      ENSP00000481633, ENST00000613087
      Conserved Domains (1) summary
      pfam15177
      Location:38196
      IL28A; Interleukin-28A

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      39735081..39736420 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)