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Dusp4 dual specificity phosphatase 4 [ Mus musculus (house mouse) ]

Gene ID: 319520, updated on 19-Jul-2014
Official Symbol
Dusp4provided by MGI
Official Full Name
dual specificity phosphatase 4provided by MGI
Primary source
MGI:2442191
See related
Ensembl:ENSMUSG00000031530; Vega:OTTMUSG00000016984
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MKP2; AI844617; BB104621; 2700078F24Rik; E130306H24Rik
See Dusp4 in Epigenomics, MapViewer
Location:
8 A4; 8
Exon count:
4
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 8 NC_000074.6 (34807610..34819894)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA B930018H19 gene Neighboring gene uncharacterized LOC102637227 Neighboring gene uncharacterized LOC102637374 Neighboring gene tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase Neighboring gene uncharacterized LOC102637601

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
MAP kinase tyrosine/serine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine/serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
protein tyrosine/threonine phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
endoderm formation IBA
Inferred from Biological aspect of Ancestor
more info
 
inactivation of MAPK activity ISO
Inferred from Sequence Orthology
more info
 
protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
 
protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
dual specificity protein phosphatase 4
Names
dual specificity protein phosphatase 4
NP_795907.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_176933.4NP_795907.1  dual specificity protein phosphatase 4

    See proteins identical to NP_795907.1

    Status: PROVISIONAL

    Source sequence(s)
    AK080964
    Consensus CDS
    CCDS22241.1
    UniProtKB/Swiss-Prot
    Q8BFV3
    Related
    ENSMUSP00000033930, OTTMUSP00000018459, ENSMUST00000033930, OTTMUST00000041196
    Conserved Domains (2) summary
    cd00127
    Location:199335
    Blast Score: 501
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
    cd01446
    Location:9162
    Blast Score: 424
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000074.6 

    Range
    34807610..34819894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000030.1 

    Range
    37423596..37435832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)