Format

Send to:

Choose Destination

Links from PubMed

    • Showing Current items.

    ALOX5AP arachidonate 5-lipoxygenase activating protein [ Homo sapiens (human) ]

    Gene ID: 241, updated on 3-Jul-2016
    Official Symbol
    ALOX5APprovided by HGNC
    Official Full Name
    arachidonate 5-lipoxygenase activating proteinprovided by HGNC
    Primary source
    HGNC:HGNC:436
    See related
    Ensembl:ENSG00000132965 HPRD:04742; MIM:603700; Vega:OTTHUMG00000016677
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FLAP
    Summary
    This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
    Orthologs
    Location:
    13q12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 13 NC_000013.11 (30713478..30764428)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (31287615..31338565)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene high mobility group box 1 Neighboring gene ubiquitin specific peptidase like 1 Neighboring gene transfer RNA-Asn (GTT) 2-4 Neighboring gene long intergenic non-protein coding RNA 398 Neighboring gene long intergenic non-protein coding RNA 545 Neighboring gene TEX26 antisense RNA 1

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Ischemic stroke
    MedGen: C0948008 OMIM: 601367 GeneReviews: Not available
    Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study for reading and language abilities in two population cohorts.
    NHGRI GWA Catalog
    A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients.
    NHGRI GWA Catalog
    • Arachidonic acid metabolism, organism-specific biosystem (from REACTOME)
      Arachidonic acid metabolism, organism-specific biosystemEicosanoids, oxygenated, 20-carbon fatty acids, are autocrine and paracrine signaling molecules that modulate physiological processes including pain, fever, inflammation, blood clot formation, smooth...
    • Eicosanoid Synthesis, organism-specific biosystem (from WikiPathways)
      Eicosanoid Synthesis, organism-specific biosystemIn biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or i...
    • IL-5 Signaling Pathway, organism-specific biosystem (from WikiPathways)
      IL-5 Signaling Pathway, organism-specific biosystemInterleukin-5 belongs to the family of cytokines, which includes IL-3 and GM-CSF. It signals through a receptor complex comprising of an IL-5 receptor alpha subunit (IL5RA), and a common beta chain w...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
      Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
    • Selenium Pathway, organism-specific biosystem (from WikiPathways)
      Selenium Pathway, organism-specific biosystem
      Selenium Pathway
    • Synthesis of 5-eicosatetraenoic acids, organism-specific biosystem (from REACTOME)
      Synthesis of 5-eicosatetraenoic acids, organism-specific biosystem5-hydroperoxy-eicosatetraenoic acid (5-HpETE), 5-hydroxyeicosatetraenoic acid (5S-HETE) and 5-oxo-eicosatetraenoic acid (5-oxoETE) are formed after the initial step of arachidonic acid oxidation by ...
    • Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystem (from REACTOME)
      Synthesis of Leukotrienes (LT) and Eoxins (EX), organism-specific biosystemLeukotrienes (LTs) are biologically active molecules formed in response to inflammatory stimuli. They cause contraction of bronchial smooth muscles, stimulation of vascular permeability, and attracti...
    • Synthesis of Lipoxins (LX), organism-specific biosystem (from REACTOME)
      Synthesis of Lipoxins (LX), organism-specific biosystemLipoxins A4 (LXA4) and B4 (LXB4), structurally characterized from human neutrophils incubated with 15-hydroperoxy-eicosatetraenoic acid (15-HpETE), each contain three hydroxyl moieties and a conjugat...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    arachidonic acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme activator activity IEA
    Inferred from Electronic Annotation
    more info
     
    NOT glutathione peroxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT leukotriene-C4 synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    protein N-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    cellular response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukotriene biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    leukotriene metabolic process TAS
    Traceable Author Statement
    more info
     
    lipoxin metabolic process TAS
    Traceable Author Statement
    more info
     
    lipoxygenase pathway TAS
    Traceable Author Statement
    more info
     
    positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein homotrimerization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear envelope TAS
    Traceable Author Statement
    more info
     
    nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    arachidonate 5-lipoxygenase-activating protein
    Names
    MK-886-binding protein

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011963.2 RefSeqGene

      Range
      27031..55951
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001204406.1NP_001191335.1  arachidonate 5-lipoxygenase-activating protein isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence which includes an upstream in-frame AUG start codon, as compared to variant 1. The resulting isoform (2) is longer at the N-terminus, as compared to isoform 1.
      Source sequence(s)
      AK314143, BC018538, BQ003388
      Consensus CDS
      CCDS73558.1
      UniProtKB/Swiss-Prot
      P20292
      UniProtKB/TrEMBL
      A0A087WW23
      Related
      ENSP00000479870, ENST00000617770
      Conserved Domains (1) summary
      pfam01124
      Location:66184
      MAPEG; MAPEG family
    2. NM_001629.3NP_001620.2  arachidonate 5-lipoxygenase-activating protein isoform 1

      See identical proteins and their annotated locations for NP_001620.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the predominant isoform (1).
      Source sequence(s)
      BC018538, BG569867, BQ003388
      Consensus CDS
      CCDS9337.1
      UniProtKB/Swiss-Prot
      P20292
      Related
      ENSP00000369858, OTTHUMP00000018204, ENST00000380490, OTTHUMT00000044372
      Conserved Domains (1) summary
      pfam01124
      Location:38127
      MAPEG; MAPEG family

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p7 Primary Assembly

      Range
      30713478..30764428
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017020522.1XP_016876011.1  

    Alternate CHM1_1.1

    Genomic

    1. NC_018924.2 Alternate CHM1_1.1

      Range
      31255200..31306135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)