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Ddr2 discoidin domain receptor family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 18214, updated on 7-Aug-2014
Official Symbol
Ddr2provided by MGI
Official Full Name
discoidin domain receptor family, member 2provided by MGI
Primary source
MGI:1345277
See related
Ensembl:ENSMUSG00000026674
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ntrkr3; tyro10; AW495251
See Ddr2 in Epigenomics, MapViewer
Location:
1 H1-H5; 1 76.84 cM
Exon count:
19
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 1 NC_000067.6 (169972307..170110849, complement)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700084C01 gene Neighboring gene RIKEN cDNA 3110045C21 gene Neighboring gene hydroxysteroid (17-beta) dehydrogenase 7 Neighboring gene UDP-N-acetylglucosamine pyrophosphorylase 1 Neighboring gene U2AF homology motif (UHM) kinase 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein tyrosine kinase collagen receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein tyrosine kinase collagen receptor activity ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring phosphorus-containing groups IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
biomineral tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IEA
Inferred from Electronic Annotation
more info
 
chondrocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
collagen-activated tyrosine kinase receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
endochondral bone growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
ossification IEA
Inferred from Electronic Annotation
more info
 
peptidyl-tyrosine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of extracellular matrix disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sequence-specific DNA binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
discoidin domain-containing receptor 2
Names
discoidin domain-containing receptor 2
discoidin domain receptor 2
tyrosine-protein kinase TYRO10
CD167 antigen-like family member B
receptor protein-tyrosine kinase TKT
neurotrophic tyrosine kinase, receptor-related 3
NP_072075.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022563.2NP_072075.2  discoidin domain-containing receptor 2 precursor

    See proteins identical to NP_072075.2

    Status: VALIDATED

    Source sequence(s)
    AC139673, AI838577, X76505
    Consensus CDS
    CCDS48436.1
    UniProtKB/Swiss-Prot
    Q62371
    Related
    ENSMUSP00000129624, ENSMUST00000170800
    Conserved Domains (3) summary
    cd05095
    Location:557850
    Blast Score: 1622
    PTKc_DDR2; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
    smart00221
    Location:563848
    Blast Score: 987
    STYKc; Protein kinase; unclassified specificity
    cd00057
    Location:32184
    Blast Score: 465
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000067.6 

    Range
    169972307..170110849
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496696.1XP_006496759.1  

    See proteins identical to XP_006496759.1

    UniProtKB/Swiss-Prot
    Q62371
    Conserved Domains (3) summary
    cd05095
    Location:557850
    Blast Score: 1622
    PTKc_DDR2; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
    smart00221
    Location:563848
    Blast Score: 987
    STYKc; Protein kinase; unclassified specificity
    cd00057
    Location:32184
    Blast Score: 465
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  2. XM_006496697.1XP_006496760.1  

    See proteins identical to XP_006496760.1

    UniProtKB/Swiss-Prot
    Q62371
    Conserved Domains (3) summary
    cd05095
    Location:557850
    Blast Score: 1622
    PTKc_DDR2; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
    smart00221
    Location:563848
    Blast Score: 987
    STYKc; Protein kinase; unclassified specificity
    cd00057
    Location:32184
    Blast Score: 465
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.
  3. XM_006496698.1XP_006496761.1  

    See proteins identical to XP_006496761.1

    UniProtKB/Swiss-Prot
    Q62371
    Conserved Domains (3) summary
    cd05095
    Location:557850
    Blast Score: 1622
    PTKc_DDR2; Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2
    smart00221
    Location:563848
    Blast Score: 987
    STYKc; Protein kinase; unclassified specificity
    cd00057
    Location:32184
    Blast Score: 465
    FA58C; Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.

Alternate Mm_Celera

Genomic

  1. AC_000023.1 

    Range
    172414199..172477876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)