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    PTPRS protein tyrosine phosphatase, receptor type S [ Homo sapiens (human) ]

    Gene ID: 5802, updated on 26-Jul-2016
    Official Symbol
    PTPRSprovided by HGNC
    Official Full Name
    protein tyrosine phosphatase, receptor type Sprovided by HGNC
    Primary source
    HGNC:HGNC:9681
    See related
    Ensembl:ENSG00000105426 HPRD:03344; MIM:601576; Vega:OTTHUMG00000180325
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    R-PTP-S; PTPSIGMA; R-PTP-sigma
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    19p13.3
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 19 NC_000019.10 (5205503..5340803, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (5205514..5340814, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ubiquitin like with PHD and ring finger domains 1 Neighboring gene microRNA 4747 Neighboring gene lysine demethylase 4B Neighboring gene uncharacterized LOC105372253 Neighboring gene ribosomal protein L32 pseudogene 34 Neighboring gene uncharacterized LOC105372252 Neighboring gene zinc and ring finger 4 Neighboring gene tissue differentiation-inducing non-protein coding RNA

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of protein tyrosine phosphatase, receptor type, Sigma (PTPRS) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of PTPRS PubMed

    Go to the HIV-1, Human Interaction Database

    • ECM proteoglycans, organism-specific biosystem (from REACTOME)
      ECM proteoglycans, organism-specific biosystemProteoglycans are major components of the extracellular matrix. In cartilage the matrix constitutes more than 90% of tissue dry weight. Proteoglycans are proteins substituted with glycosaminoglycans ...
    • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
      Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
    • Neuronal System, organism-specific biosystem (from REACTOME)
      Neuronal System, organism-specific biosystemThe human brain contains at least 100 billion neurons, each with the ability to influence many other cells. Clearly, highly sophisticated and efficient mechanisms are needed to enable communication a...
    • SALM protein interactions at the synapse, organism-specific biosystem (from REACTOME)
      SALM protein interactions at the synapse, organism-specific biosystemRecruitment of receptors and ion channels to the postsynaptic membrane is the last step in synapse formation. Many of these proteins interact directly or indirectly with postsynaptic density-95 (PSD9...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transmembrane receptor protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    cerebellum development IEA
    Inferred from Electronic Annotation
    more info
     
    cerebral cortex development IEA
    Inferred from Electronic Annotation
    more info
     
    chemical synaptic transmission TAS
    Traceable Author Statement
    more info
     
    corpus callosum development IEA
    Inferred from Electronic Annotation
    more info
     
    establishment of endothelial intestinal barrier IEA
    Inferred from Electronic Annotation
    more info
     
    hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-tyrosine dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    spinal cord development IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    integral component of plasma membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     
    Preferred Names
    receptor-type tyrosine-protein phosphatase S
    Names
    protein tyrosine phosphatase PTPsigma
    protein tyrosine phosphatase, receptor type, S
    receptor-type tyrosine-protein phosphatase sigma
    NP_002841.3
    NP_570923.2
    NP_570924.2
    NP_570925.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033964.1 RefSeqGene

      Range
      5001..140296
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002850.3NP_002841.3  receptor-type tyrosine-protein phosphatase S isoform 1 precursor

      See identical proteins and their annotated locations for NP_002841.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AB209333, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
      Consensus CDS
      CCDS45930.1
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      Q59FX6, Q8NHS7
      Related
      ENSP00000349932, ENST00000357368
      Conserved Domains (9) summary
      cd05738
      Location:152235
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:259327
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150223
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13921647
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:251328
      IG_like; Immunoglobulin like
      cd00047
      Location:14181647
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:332421
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    2. NM_130853.2NP_570923.2  receptor-type tyrosine-protein phosphatase S isoform 3 precursor

      See identical proteins and their annotated locations for NP_570923.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC118535, BC029496, BC104812
      Consensus CDS
      CCDS12139.1
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      Q59FX6, Q8NHS7
      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9451200
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:9711200
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    3. NM_130854.2NP_570924.2  receptor-type tyrosine-protein phosphatase S isoform 2 precursor

      See identical proteins and their annotated locations for NP_570924.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks four internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks four internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC118535, BC029496, BC104812, CN413749, CN413752, U35234, U40317
      Consensus CDS
      CCDS12140.1
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      Q59FX6, Q8NHS7
      Related
      ENSP00000269907, ENST00000348075
      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13541609
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13801609
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    4. NM_130855.2NP_570925.2  receptor-type tyrosine-protein phosphatase S isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks three internal fragments within the coding region when compared to variant 1. The translation remains in-frame, and thus results in a protein that lacks three internal segments, as compared to isoform 1.
      Source sequence(s)
      AB209333, AC118535, BC029496, BC104812, U35234
      Consensus CDS
      CCDS74265.1
      UniProtKB/Swiss-Prot
      Q13332
      UniProtKB/TrEMBL
      A0A0A0MR60, Q59FX6, Q8NHS7
      Related
      ENSP00000327313, ENST00000353284
      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:250318
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9491204
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:242319
      IG_like; Immunoglobulin like
      cd00047
      Location:9751204
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:323412
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p7 Primary Assembly

      Range
      5205503..5340803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027066.1XP_016882555.1  

    2. XM_005259607.2XP_005259664.1  

      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13501605
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13761605
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    3. XM_005259606.2XP_005259663.1  

      See identical proteins and their annotated locations for XP_005259663.1

      UniProtKB/Swiss-Prot
      Q13332
      Related
      ENSP00000465443, OTTHUMP00000263971, ENST00000588012, OTTHUMT00000450764
      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13541609
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:13801609
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    4. XM_005259600.2XP_005259657.1  

      See identical proteins and their annotated locations for XP_005259657.1

      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:13791634
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:14051634
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    5. XM_017027072.1XP_016882561.1  

    6. XM_017027069.1XP_016882558.1  

    7. XM_017027071.1XP_016882560.1  

    8. XM_017027068.1XP_016882557.1  

    9. XM_017027070.1XP_016882559.1  

    10. XM_017027065.1XP_016882554.1  

    11. XM_005259610.1XP_005259667.1  

      Related
      ENSP00000262963, ENST00000262963
      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9411196
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:9671196
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    12. XM_005259609.1XP_005259666.1  

      See identical proteins and their annotated locations for XP_005259666.1

      UniProtKB/Swiss-Prot
      Q13332
      Related
      ENSP00000467398, OTTHUMP00000263970, ENST00000592099, OTTHUMT00000450763
      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9451200
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:9711200
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    13. XM_017027075.1XP_016882564.1  

    14. XM_017027076.1XP_016882565.1  

    15. XM_017027074.1XP_016882563.1  

    16. XM_017027067.1XP_016882556.1  

    17. XM_011528157.2XP_011526459.1  

      Conserved Domains (9) summary
      cd05738
      Location:152226
      Ig2_RPTP_IIa_LAR_like; Second immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      cd05739
      Location:246314
      Ig3_RPTP_IIa_LAR_like; Third immunoglobulin (Ig)-like domain of the receptor protein tyrosine phosphatase (RPTP)-F, also known as LAR
      smart00408
      Location:150214
      IGc2; Immunoglobulin C-2 Type
      smart00194
      Location:9611216
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00410
      Location:238315
      IG_like; Immunoglobulin like
      cd00047
      Location:9871216
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:319408
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:33124
      I-set; Immunoglobulin I-set domain
      cl11960
      Location:32120
      Ig; Immunoglobulin domain
    18. XM_017027073.1XP_016882562.1  

    19. XM_011528158.2XP_011526460.1  

      Conserved Domains (3) summary
      smart00194
      Location:601856
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:627856
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00063
      Location:141238
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    Alternate CHM1_1.1

    Genomic

    1. NC_018930.2 Alternate CHM1_1.1

      Range
      5205046..5340693 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)