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Fmr1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37528, updated on 7-Dec-2014
Official Symbol
Fmr1provided by FlyBase
Primary source
FLYBASE:FBgn0028734
Locus tag
Dmel_CG6203
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AT24755; BcDNA:GM08679; cg6203; CG6203; dfmr; dFMR; dfmr1; dFmr1; dFMR1; dFmrp; dFMRP; dfxr; dFXR; dfxr1; dFXR1; dFXRP; Dmel\CG6203; dmfr1; EP(3)3517; fmr; FMR; fmr1; FMR1; Fmrp; FMRp; FMRP; FXR
See Fmr1 in Epigenomics, MapViewer
Location:
85F10-85F12
Exon count:
14
Annotation release Status Assembly Chr Location
Release 6.01 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10101420..10110121, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (5927142..5935843, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene mir-277 stem loop Neighboring gene mir-34 stem loop Neighboring gene CG3940 gene product from transcript CG3940-RB Neighboring gene gamma Soluble NSF attachment protein 2

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • RNA transport, organism-specific biosystem (from KEGG)
    RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
  • RNA transport, conserved biosystem (from KEGG)
    RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding IPI
Inferred from Physical Interaction
more info
PubMed 
mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mRNA binding NAS
Non-traceable Author Statement
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein self-association IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonal fasciculation IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellularization IDA
Inferred from Direct Assay
more info
PubMed 
cellularization IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
circadian sleep/wake cycle, sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
detection of mechanical stimulus involved in sensory perception of touch IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
germ cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ-line cyst formation IGI
Inferred from Genetic Interaction
more info
PubMed 
germ-line cyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
germarium-derived oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
habituation IMP
Inferred from Mutant Phenotype
more info
PubMed 
heterochromatin assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
larval locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotion TAS
Traceable Author Statement
more info
PubMed 
locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
mRNA transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
male courtship behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
male courtship behavior TAS
Traceable Author Statement
more info
PubMed 
mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
PubMed 
mushroom body development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of imaginal disc growth IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of synaptic growth at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of translation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of translation IEP
Inferred from Expression Pattern
more info
PubMed 
negative regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular junction development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
olfactory learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte dorsal/ventral axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT phototaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pole cell formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle, embryonic IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of neuromuscular synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of olfactory learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse structural plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic growth at neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translation NAS
Non-traceable Author Statement
more info
PubMed 
short-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT short-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
synapse assembly NAS
Non-traceable Author Statement
more info
PubMed 
synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
RISC complex IPI
Inferred from Physical Interaction
more info
PubMed 
RISC complex TAS
Traceable Author Statement
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
lipid particle IDA
Inferred from Direct Assay
more info
PubMed 
micro-ribonucleoprotein complex TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
CG6203 gene product from transcript CG6203-RC
Names
CG6203-PA
CG6203-PB
CG6203-PC
CG6203-PD
CG6203-PE
CG6203-PF
CG6203-PG
CG6203-PH
CG6203-PI
Fmr1
Fmr1-PA
Fmr1-PB
Fmr1-PC
Fmr1-PD
Fmr1-PE
Fmr1-PF
Fmr1-PG
Fmr1-PH
Fmr1-PI
Fragile-X mental retardation protein
Fragile-X-related
dFMR
dFmr1
drosophila fragile X mental retardation protein
fragile X
fragile X mental retardation
fragile X mental retardation 1
fragile X mental retardation gene
fragile X mental retardation protein
fragile X protein
fragile X related protein
fragile X-related
fragile x related
fragile-X
NP_001247017.1
  • non-AUG (CUG) translation initiation
NP_001262447.1
  • non-AUG (CUG) translation initiation

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 

    Range
    10101420..10110121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_169324.2NP_731443.1  Fmr1, isoform C [Drosophila melanogaster]

    See proteins identical to NP_731443.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    Related
    FBpp0081676, FBtr0082198
    Conserved Domains (4) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:289357
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:366407
    FXR1P_C; Fragile X-related 1 protein C terminal
    pfam15320
    Location:440474
    RAM; mRNA cap methylation, RNMT-activating mini protein
  2. NM_001260088.1NP_001247017.1  Fmr1, isoform G [Drosophila melanogaster]

    See proteins identical to NP_001247017.1

    Status: REVIEWED

    Related
    FBpp0300445, FBtr0308123
    Conserved Domains (3) summary
    smart00743
    Location:107163
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:337405
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:414455
    FXR1P_C; Fragile X-related 1 protein C terminal
  3. NM_169326.3NP_731445.1  Fmr1, isoform E [Drosophila melanogaster]

    See proteins identical to NP_731445.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    Related
    FBpp0081678, FBtr0082200
    Conserved Domains (3) summary
    smart00743
    Location:2177
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:251319
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:328369
    FXR1P_C; Fragile X-related 1 protein C terminal
  4. NM_001275519.1NP_001262448.1  Fmr1, isoform I [Drosophila melanogaster]

    See proteins identical to NP_001262448.1

    Status: REVIEWED

    Conserved Domains (4) summary
    smart00743
    Location:2177
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:251315
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:324365
    FXR1P_C; Fragile X-related 1 protein C terminal
    pfam15320
    Location:398432
    RAM; mRNA cap methylation, RNMT-activating mini protein
  5. NM_001170109.2NP_001163580.1  Fmr1, isoform F [Drosophila melanogaster]

    See proteins identical to NP_001163580.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3LF78
    Related
    FBpp0290600, FBtr0301386
    Conserved Domains (4) summary
    smart00743
    Location:2177
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:251322
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:331372
    FXR1P_C; Fragile X-related 1 protein C terminal
    pfam15320
    Location:405439
    RAM; mRNA cap methylation, RNMT-activating mini protein
  6. NM_137801.4NP_611645.1  Fmr1, isoform A [Drosophila melanogaster]

    See proteins identical to NP_611645.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    Related
    FBpp0081675, FBtr0082197
    Conserved Domains (4) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:289360
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:369410
    FXR1P_C; Fragile X-related 1 protein C terminal
    pfam15320
    Location:443477
    RAM; mRNA cap methylation, RNMT-activating mini protein
  7. NM_169325.3NP_731444.1  Fmr1, isoform D [Drosophila melanogaster]

    See proteins identical to NP_731444.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    Related
    FBpp0081677, FBtr0082199
    Conserved Domains (4) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:289357
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:366407
    FXR1P_C; Fragile X-related 1 protein C terminal
    pfam15320
    Location:440474
    RAM; mRNA cap methylation, RNMT-activating mini protein
  8. NM_169327.2NP_731446.1  Fmr1, isoform B [Drosophila melanogaster]

    See proteins identical to NP_731446.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9NFU0
    Related
    FBpp0081674, FBtr0082196
    Conserved Domains (4) summary
    smart00743
    Location:59115
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:289350
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:359400
    FXR1P_C; Fragile X-related 1 protein C terminal
    pfam15320
    Location:433467
    RAM; mRNA cap methylation, RNMT-activating mini protein
  9. NM_001275518.1NP_001262447.1  Fmr1, isoform H [Drosophila melanogaster]

    See proteins identical to NP_001262447.1

    Status: REVIEWED

    Conserved Domains (4) summary
    smart00743
    Location:107163
    Agenet; Tudor-like domain present in plant sequences
    cd00105
    Location:337398
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    pfam12235
    Location:407448
    FXR1P_C; Fragile X-related 1 protein C terminal
    pfam15320
    Location:481515
    RAM; mRNA cap methylation, RNMT-activating mini protein