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GSTZ1 glutathione S-transferase zeta 1 [ Homo sapiens (human) ]

Gene ID: 2954, updated on 11-Sep-2014
Official Symbol
GSTZ1provided by HGNC
Official Full Name
glutathione S-transferase zeta 1provided by HGNC
Primary source
HGNC:HGNC:4643
See related
Ensembl:ENSG00000100577; HPRD:04785; MIM:603758; Vega:OTTHUMG00000171551
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MAI; MAAI; GSTZ1-1
Summary
This gene is a member of the glutathione S-transferase (GSTs) super-family which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus defects in this enzyme may lead to severe metabolic disorders including alkaptonuria, phenylketonuria and tyrosinaemia. Several transcript variants of this gene encode multiple protein isoforms. [provided by RefSeq, Jul 2008]
See GSTZ1 in Epigenomics, MapViewer
Location:
14q24.3
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 14 NC_000014.9 (77320887..77331597)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (77787230..77797940)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene microRNA 1260a Neighboring gene neuroglobin Neighboring gene protein-O-mannosyltransferase 2 Neighboring gene transmembrane emp24 protein transport domain containing 8 Neighboring gene ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) pseudogene Neighboring gene sterile alpha motif domain containing 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Replication interactions

Interaction Pubs
Knockdown of glutathione transferase zeta 1 (GSTZ1) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC2029

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione peroxidase activity TAS
Traceable Author Statement
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
maleylacetoacetate isomerase activity EXP
Inferred from Experiment
more info
 
maleylacetoacetate isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
 
L-phenylalanine catabolic process TAS
Traceable Author Statement
more info
 
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process TAS
Traceable Author Statement
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
tyrosine catabolic process IEA
Inferred from Electronic Annotation
more info
 
xenobiotic metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
Preferred Names
maleylacetoacetate isomerase
Names
maleylacetoacetate isomerase
maleylacetone isomerase
glutathione S-aryltransferase
glutathione S-alkyltransferase
glutathione transferase zeta 1
glutathione S-aralkyltransferase
S-(hydroxyalkyl)glutathione lyase
NP_001504.2
NP_665877.1
NP_665878.2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001513.3NP_001504.2  maleylacetoacetate isomerase isoform 3

    See proteins identical to NP_001504.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exons and uses a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
    Source sequence(s)
    AJ001838, BC001453, BI559916
    Consensus CDS
    CCDS9860.1
    UniProtKB/Swiss-Prot
    O43708
    Related
    ENSP00000377335, ENST00000393734
    Conserved Domains (2) summary
    cd03191
    Location:38152
    Blast Score: 496
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cl00388
    Location:125
    Blast Score: 129
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  2. NM_145870.2NP_665877.1  maleylacetoacetate isomerase isoform 1

    See proteins identical to NP_665877.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ001838, BC001453, BG772450
    Consensus CDS
    CCDS9858.1
    UniProtKB/Swiss-Prot
    O43708
    Related
    ENSP00000216465, OTTHUMP00000246405, ENST00000216465, OTTHUMT00000414082
    Conserved Domains (3) summary
    cd03191
    Location:93207
    Blast Score: 499
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    TIGR01262
    Location:7211
    Blast Score: 919
    maiA; maleylacetoacetate isomerase
    cd03042
    Location:680
    Blast Score: 378
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  3. NM_145871.2NP_665878.2  maleylacetoacetate isomerase isoform 2

    See proteins identical to NP_665878.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AJ001838, BC001453, BG772450
    Consensus CDS
    CCDS9859.1
    UniProtKB/Swiss-Prot
    O43708
    Conserved Domains (3) summary
    cd03191
    Location:73165
    Blast Score: 406
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    TIGR01262
    Location:7169
    Blast Score: 682
    maiA; maleylacetoacetate isomerase
    cd03042
    Location:672
    Blast Score: 329
    GST_N_Zeta; GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000014.9 

    Range
    77320887..77331597
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005267559.1XP_005267616.1  

    See proteins identical to XP_005267616.1

    UniProtKB/Swiss-Prot
    O43708
    Conserved Domains (2) summary
    cd03191
    Location:38152
    Blast Score: 496
    GST_C_Zeta; C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases
    cl00388
    Location:125
    Blast Score: 129
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

Alternate HuRef

Genomic

  1. AC_000146.1 

    Range
    57953339..57964018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018925.2 

    Range
    77726689..77737398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)