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    CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase [ Homo sapiens (human) ]

    Gene ID: 790, updated on 7-Feb-2016
    Official Symbol
    CADprovided by HGNC
    Official Full Name
    carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotaseprovided by HGNC
    Primary source
    HGNC:HGNC:1424
    See related
    Ensembl:ENSG00000084774; HPRD:06437; MIM:114010; Vega:OTTHUMG00000097070
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Orthologs
    Location:
    2p22-p21
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (27217390..27243792)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27440258..27466660)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene transcription factor 23 Neighboring gene solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 Neighboring gene all-trans retinoic acid induced differentiation factor Neighboring gene solute carrier family 30 (zinc transporter), member 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 gamma

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Replication interactions

    Interaction Pubs
    Knockdown of carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase (CAD) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify carbamoyl-phosphate synthetase 2 (CAD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify carbamoyl-phosphate synthetase 2 (CAD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify carbamoyl-phosphate synthetase 2 (CAD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify carbamoyl-phosphate synthetase 2 (CAD), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aspartate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aspartate carbamoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    aspartate carbamoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aspartate carbamoyltransferase activity TAS
    Traceable Author Statement
    more info
     
    carbamoyl-phosphate synthase (ammonia) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity TAS
    Traceable Author Statement
    more info
     
    dihydroorotase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dihydroorotase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    dihydroorotase activity TAS
    Traceable Author Statement
    more info
     
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    'de novo' UMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    'de novo' pyrimidine nucleobase biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    'de novo' pyrimidine nucleobase biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    cellular response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to epidermal growth factor stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    drug metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    glutamine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    lactation IEA
    Inferred from Electronic Annotation
    more info
     
    liver development IEA
    Inferred from Electronic Annotation
    more info
     
    nucleobase-containing small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    organ regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    peptidyl-threonine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    pyrimidine nucleobase metabolic process TAS
    Traceable Author Statement
    more info
     
    pyrimidine nucleoside biosynthetic process TAS
    Traceable Author Statement
    more info
     
    response to amine IEA
    Inferred from Electronic Annotation
    more info
     
    response to caffeine IEA
    Inferred from Electronic Annotation
    more info
     
    response to cortisol IEA
    Inferred from Electronic Annotation
    more info
     
    response to testosterone IEA
    Inferred from Electronic Annotation
    more info
     
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
     
    urea cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    cell projection ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
     
    extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein complex IEA
    Inferred from Electronic Annotation
    more info
     
    terminal bouton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Preferred Names
    CAD protein
    Names
    CAD trifunctional protein
    multifunctional protein CAD
    NP_004332.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_046394.1 RefSeqGene

      Range
      5001..31403
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001306079.1NP_001293008.1  CAD protein isoform 2

      See identical proteins and their annotated locations for NP_001293008.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1.
      Source sequence(s)
      AK226105, BC065510, BG766243, BQ447516
      Consensus CDS
      CCDS77396.1
      UniProtKB/TrEMBL
      F8VPD4
      UniProtKB/Swiss-Prot
      P27708
      Conserved Domains (13) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      smart01096
      Location:736858
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
      smart01097
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      PRK00856
      Location:18572161
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:13971743
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:12501375
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      pfam00185
      Location:20082158
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00289
      Location:393508
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02729
      Location:18612003
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      TIGR00857
      Location:13981733
      pyrC_multi; dihydroorotase, multifunctional complex type
      TIGR01369
      Location:3911377
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      cl17255
      Location:514655
      ATP-grasp_4; ATP-grasp domain
    2. NM_004341.4NP_004332.2  CAD protein isoform 1

      See identical proteins and their annotated locations for NP_004332.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC065510, BM927624, BQ447516, BU541191, BU558264, D78586
      Consensus CDS
      CCDS1742.1
      UniProtKB/Swiss-Prot
      P27708
      Related
      ENSP00000264705, OTTHUMP00000122585, ENST00000264705, OTTHUMT00000214186
      Conserved Domains (14) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      pfam02786
      Location:514718
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      smart01096
      Location:799921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
      smart01097
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      PRK00856
      Location:19202224
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:14601806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:13131438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      pfam00185
      Location:20712221
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00289
      Location:393508
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02729
      Location:19242066
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      TIGR00857
      Location:14611796
      pyrC_multi; dihydroorotase, multifunctional complex type
      TIGR01369
      Location:3911440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      cl17255
      Location:10481245
      ATP-grasp_4; ATP-grasp domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

      Range
      27217390..27243792
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264555.2XP_005264612.1  

      Conserved Domains (14) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      pfam02786
      Location:514718
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      smart01096
      Location:799921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
      smart01097
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      PRK00856
      Location:19372241
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:14601806
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:13131438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      pfam00185
      Location:20882238
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00289
      Location:393508
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02729
      Location:19412083
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      TIGR00857
      Location:14611796
      pyrC_multi; dihydroorotase, multifunctional complex type
      TIGR01369
      Location:3911440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      cl17255
      Location:10481245
      ATP-grasp_4; ATP-grasp domain
    2. XM_005264556.2XP_005264613.1  

      Conserved Domains (14) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      pfam02786
      Location:514718
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      smart01096
      Location:799921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
      smart01097
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      PRK00856
      Location:19032207
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:14601798
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:13131438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      pfam00185
      Location:20542204
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00289
      Location:393508
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02729
      Location:19072049
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      TIGR00857
      Location:14611796
      pyrC_multi; dihydroorotase, multifunctional complex type
      TIGR01369
      Location:3911440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      cl17255
      Location:10481245
      ATP-grasp_4; ATP-grasp domain
    3. XM_005264557.2XP_005264614.1  

      Conserved Domains (14) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      pfam02786
      Location:514718
      CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain
      smart01096
      Location:799921
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
      smart01097
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      PRK00856
      Location:18862190
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:14601798
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:13131438
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      pfam00185
      Location:20372187
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00289
      Location:393508
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02729
      Location:18902032
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      TIGR00857
      Location:14611796
      pyrC_multi; dihydroorotase, multifunctional complex type
      TIGR01369
      Location:3911440
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      cl17255
      Location:10481245
      ATP-grasp_4; ATP-grasp domain
    4. XM_006712101.1XP_006712164.1  

      Conserved Domains (13) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      smart01096
      Location:736858
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
      smart01097
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      PRK00856
      Location:18742178
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:13971743
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:12501375
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      pfam00185
      Location:20252175
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00289
      Location:393508
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02729
      Location:18782020
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      TIGR00857
      Location:13981733
      pyrC_multi; dihydroorotase, multifunctional complex type
      TIGR01369
      Location:3911377
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      cl17255
      Location:514655
      ATP-grasp_4; ATP-grasp domain
    5. XM_005264558.2XP_005264615.1  

      Related
      ENSP00000384510, OTTHUMP00000201035, ENST00000403525, OTTHUMT00000324970
      Conserved Domains (13) summary
      cd01744
      Location:178354
      GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II
      smart01096
      Location:736858
      CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerisation domain
      smart01097
      Location:2138
      CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain
      PRK00856
      Location:18572161
      pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional
      PRK12564
      Location:1355
      PRK12564; carbamoyl phosphate synthase small subunit; Reviewed
      cd01316
      Location:13971743
      CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the ...
      cd01423
      Location:12501375
      MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain.
      pfam00185
      Location:20082158
      OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain
      pfam00289
      Location:393508
      CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
      pfam02729
      Location:18612003
      OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
      TIGR00857
      Location:13981733
      pyrC_multi; dihydroorotase, multifunctional complex type
      TIGR01369
      Location:3911377
      CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
      cl17255
      Location:514655
      ATP-grasp_4; ATP-grasp domain

    Alternate CHM1_1.1

    Genomic

    1. NC_018913.2 Alternate CHM1_1.1

      Range
      27370163..27396559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)