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Pafah1b1 platelet-activating factor acetylhydrolase, isoform 1b, subunit 1 [ Mus musculus (house mouse) ]

Gene ID: 18472, updated on 6-Jul-2014
Official Symbol
Pafah1b1provided by MGI
Official Full Name
platelet-activating factor acetylhydrolase, isoform 1b, subunit 1provided by MGI
Primary source
MGI:109520
Locus tag
RP23-194P5.2
See related
Ensembl:ENSMUSG00000020745; Vega:OTTMUSG00000006184
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lis1; Mdsh; LIS-1; Ms10u; Pafaha; MMS10-U
See Pafah1b1 in Epigenomics, MapViewer
Location:
11 B3; 11 45.76 cM
Exon count :
12
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 11 NC_000077.6 (74673949..74724384, complement)

Chromosome 11 - NC_000077.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130309D14 gene Neighboring gene clustered mitochondria (cluA/CLU1) homolog Neighboring gene methyltransferase like 16 Neighboring gene max binding protein

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
dynein binding ISO
Inferred from Sequence Orthology
more info
 
dynein intermediate chain binding ISO
Inferred from Sequence Orthology
more info
 
microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
microtubule binding ISO
Inferred from Sequence Orthology
more info
 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein complex binding ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acrosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
adult locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
adult locomotory behavior ISO
Inferred from Sequence Orthology
more info
 
ameboidal cell migration IMP
Inferred from Mutant Phenotype
more info
 
brain morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex development IGI
Inferred from Genetic Interaction
more info
PubMed 
cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
cerebral cortex development ISO
Inferred from Sequence Orthology
more info
 
cerebral cortex neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
corpus callosum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
establishment of centrosome localization ISO
Inferred from Sequence Orthology
more info
 
establishment of mitotic spindle orientation ISO
Inferred from Sequence Orthology
more info
 
hippocampus development IGI
Inferred from Genetic Interaction
more info
PubMed 
hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
layer formation in cerebral cortex IGI
Inferred from Genetic Interaction
more info
PubMed 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
microtubule cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 
microtubule organizing center organization ISO
Inferred from Sequence Orthology
more info
 
microtubule-based process ISO
Inferred from Sequence Orthology
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
 
negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process controlling balance IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
 
neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron migration ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope disassembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear migration ISO
Inferred from Sequence Orthology
more info
 
osteoclast development IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
protein secretion IMP
Inferred from Mutant Phenotype
more info
 
regulation of Rho GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
retrograde axon cargo transport IDA
Inferred from Direct Assay
more info
PubMed 
stem cell division ISO
Inferred from Sequence Orthology
more info
 
synaptic transmission IMP
Inferred from Mutant Phenotype
more info
PubMed 
transmission of nerve impulse IMP
Inferred from Mutant Phenotype
more info
PubMed 
transport IEA
Inferred from Electronic Annotation
more info
 
vesicle transport along microtubule IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
astral microtubule ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
cell IGI
Inferred from Genetic Interaction
more info
PubMed 
cell cortex ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cell leading edge IDA
Inferred from Direct Assay
more info
PubMed 
centrosome IDA
Inferred from Direct Assay
more info
PubMed 
centrosome ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
extracellular vesicular exosome ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
intracellular IGI
Inferred from Genetic Interaction
more info
PubMed 
kinesin complex ISO
Inferred from Sequence Orthology
more info
 
kinetochore ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
microtubule associated complex IDA
Inferred from Direct Assay
more info
PubMed 
microtubule associated complex ISO
Inferred from Sequence Orthology
more info
 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
motile primary cilium IDA
Inferred from Direct Assay
more info
PubMed 
neuron projection ISO
Inferred from Sequence Orthology
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
NOT nonmotile primary cilium IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
vesicle ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
platelet-activating factor acetylhydrolase IB subunit alpha
Names
platelet-activating factor acetylhydrolase IB subunit alpha
PAFAH alpha
PAF-AH alpha
PAF-AH 45 kDa subunit
lissencephaly-1 protein
PAF acetylhydrolase 45 kDa subunit
platelet-activating factor acetylhydrolase 1b, regulatory subunit 1
platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit
NP_038653.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013625.4NP_038653.1  platelet-activating factor acetylhydrolase IB subunit alpha

    See proteins identical to NP_038653.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes a functional protein.
    Source sequence(s)
    AK144908, AK168929, BE456911, BQ895724
    Consensus CDS
    CCDS25035.1
    UniProtKB/Swiss-Prot
    P63005
    UniProtKB/TrEMBL
    Q5SW18
    Related
    ENSMUSP00000021091, OTTMUSP00000006469, ENSMUST00000021091, OTTMUST00000013927
    Conserved Domains (3) summary
    pfam08513
    Location:935
    Blast Score: 109
    LisH; LisH
    COG2319
    Location:97410
    Blast Score: 457
    COG2319; FOG: WD40 repeat [General function prediction only]
    cd00200
    Location:104408
    Blast Score: 888
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_037610.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK147507, AK160764, AK168929, BE456911

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000077.6 

    Range
    74673949..74724384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000033.1 

    Range
    82183767..82236827
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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