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Glp1r glucagon-like peptide 1 receptor [ Rattus norvegicus (Norway rat) ]

Gene ID: 25051, updated on 22-Aug-2014
Official Symbol
Glp1rprovided by RGD
Official Full Name
glucagon-like peptide 1 receptorprovided by RGD
Primary source
RGD:2703
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Also known as
Glip; RATGL1RCP
Summary
induces insulin secretion; mediates neuroendocrine signaling of feeding behavior; mediates cardiovascular response and increased blood pressure [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
See Glp1r in MapViewer
Location:
20p12
Exon count:
14
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (9586003..9626228)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 20 NC_005119.3 (11768479..11808416)

Chromosome 20 - NC_005119.4Genomic Context describing neighboring genes Neighboring gene dynein, axonemal, heavy chain 8 Neighboring gene 40S ribosomal protein S12 pseudogene Neighboring gene eukaryotic translation initiation factor 3 subunit I-like Neighboring gene uromodulin-like 1 Neighboring gene ATP-binding cassette, subfamily G (WHITE), member 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
G-protein coupled peptide receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
glucagon receptor activity IEA
Inferred from Electronic Annotation
more info
 
peptide hormone binding IDA
Inferred from Direct Assay
more info
PubMed 
peptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
adenylate cyclase-activating G-protein coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
associative learning IDA
Inferred from Direct Assay
more info
PubMed 
cAMP-mediated signaling IEA
Inferred from Electronic Annotation
more info
 
cAMP-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cellular response to glucagon stimulus IEA
Inferred from Electronic Annotation
more info
 
feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
hormone secretion IDA
Inferred from Direct Assay
more info
PubMed 
insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning or memory ISO
Inferred from Sequence Orthology
more info
 
memory IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
Not positive regulation of glucose import IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of heart contraction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of insulin secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
release of sequestered calcium ion into cytosol IDA
Inferred from Direct Assay
more info
PubMed 
response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
glucagon-like peptide 1 receptor
Names
glucagon-like peptide 1 receptor
GLP-1R
GLP-1-R
GLP-1 receptor
pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012728.1NP_036860.1  glucagon-like peptide 1 receptor precursor

    See proteins identical to NP_036860.1

    Status: PROVISIONAL

    Source sequence(s)
    M97797
    UniProtKB/Swiss-Prot
    P32301
    Conserved Domains (2) summary
    pfam00002
    Location:141398
    Blast Score: 764
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:59128
    Blast Score: 212
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005119.4 

    Range
    9586003..9626228
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_362045.2 RNA Sequence

Alternate Rn_Celera

Genomic

  1. AC_000088.1 

    Range
    10499202..10536348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)