Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    Srd5a1 steroid 5 alpha-reductase 1 [ Mus musculus (house mouse) ]

    Gene ID: 78925, updated on 4-Jul-2015
    Official Symbol
    Srd5a1provided by MGI
    Official Full Name
    steroid 5 alpha-reductase 1provided by MGI
    Primary source
    MGI:MGI:98400
    See related
    Ensembl:ENSMUSG00000021594; Vega:OTTMUSG00000035506
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S5AR 1; Srd5a-1; 0610031P22Rik; 4930435F02Rik
    Orthologs
    See Srd5a1 in Epigenomics, MapViewer
    Location:
    13 C1; 13 35.55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    105 current GRCm38.p3 (GCF_000001635.23) 13 NC_000079.6 (69573449..69611900, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (69712327..69750341, complement)

    Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A530095I07 gene Neighboring gene predicted gene, 40992 Neighboring gene RAB geranylgeranyl transferase, b subunit pseudogene Neighboring gene NOL1/NOP2/Sun domain family member 2 Neighboring gene importin 7 pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    3-oxo-5-alpha-steroid 4-dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    3-oxo-5-alpha-steroid 4-dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NADPH binding ISO
    Inferred from Sequence Orthology
    more info
     
    amide binding ISO
    Inferred from Sequence Orthology
    more info
     
    cholestenone 5-alpha-reductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    androgen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    androgen biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    androgen metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    oxidation-reduction process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    progesterone metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    response to drug ISO
    Inferred from Sequence Orthology
    more info
     
    sex differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    steroid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    cell body fiber ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    3-oxo-5-alpha-steroid 4-dehydrogenase 1
    Names
    SR type 1
    steroid 5-alpha-reductase 1
    type 1 5alpha-reductase
    NP_780492.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175283.3NP_780492.2  3-oxo-5-alpha-steroid 4-dehydrogenase 1

      See identical proteins and their annotated locations for NP_780492.2

      Status: VALIDATED

      Source sequence(s)
      BB585840, BC079863
      Consensus CDS
      CCDS26624.1
      UniProtKB/Swiss-Prot
      Q68FF9
      Related
      ENSMUSP00000089097, OTTMUSP00000050010, ENSMUST00000091514, OTTMUST00000090926
      Conserved Domains (1) summary
      pfam02544
      Location:106255
      Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p3 C57BL/6J

    Genomic

    1. NC_000079.6 Reference GRCm38.p3 C57BL/6J

      Range
      69573449..69611900
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006517474.2XP_006517537.1  

      Conserved Domains (1) summary
      cl21511
      Location:106184
      PEMT; Phospholipid methyltransferase
    2. XM_006517473.2XP_006517536.1  

      See identical proteins and their annotated locations for XP_006517536.1

      UniProtKB/TrEMBL
      Q8BUR8
      Conserved Domains (1) summary
      cl21511
      Location:106183
      PEMT; Phospholipid methyltransferase

    Alternate Mm_Celera

    Genomic

    1. AC_000035.1 Alternate Mm_Celera

      Range
      71919533..71956201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)