Display Settings:

Format

Send to:

Choose Destination

EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 [ Homo sapiens (human) ]

Gene ID: 1981, updated on 19-Jul-2014
Official Symbol
EIF4G1provided by HGNC
Official Full Name
eukaryotic translation initiation factor 4 gamma, 1provided by HGNC
Primary source
HGNC:3296
See related
Ensembl:ENSG00000114867; HPRD:06774; MIM:600495; Vega:OTTHUMG00000156784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P220; EIF4F; EIF4G; EIF4GI; PARK18; EIF-4G1
Summary
The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]
See EIF4G1 in Epigenomics, MapViewer
Location:
3q27.1
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 3 NC_000003.12 (184314495..184335358)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (184032283..184053146)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene endothelin converting enzyme 2 Neighboring gene calcium/calmodulin-dependent protein kinase II inhibitor 2 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 Neighboring gene small nucleolar RNA, C/D box 66 Neighboring gene family with sequence similarity 131, member A Neighboring gene chloride channel, voltage-sensitive 2 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide H

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The initiation factor eIF4G is required for the synthesis of the Gag polyprotein by a classical cap-dependent mechanism PubMed
Tat tat HIV-1 Tat co-localizes with eIF4G in cytoplasmic stress granules under stress conditions PubMed
retropepsin gag-pol Purified HIV-1 protease cleaves eIF4GI at positions 678, 681, and 1086 leading to inhibition of protein synthesis directed by capped mRNAs PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp686A1451

Gene Ontology Provided by GOA

Function Evidence Code Pubs
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
translation factor activity, nucleic acid binding TAS
Traceable Author Statement
more info
PubMed 
translation initiation factor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
RNA metabolic process TAS
Traceable Author Statement
more info
 
cell death IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
gene expression TAS
Traceable Author Statement
more info
 
insulin receptor signaling pathway TAS
Traceable Author Statement
more info
 
mRNA metabolic process TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA poly(A) tail shortening TAS
Traceable Author Statement
more info
 
regulation of translational initiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of translational initiation NAS
Non-traceable Author Statement
more info
PubMed 
translation TAS
Traceable Author Statement
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
eukaryotic translation initiation factor 4F complex TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
eukaryotic translation initiation factor 4 gamma 1
Names
eukaryotic translation initiation factor 4 gamma 1
EIF4-gamma
eIF-4-gamma 1
eucaryotic translation initiation factor 4G

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016850.1 

    Range
    4928..25791
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001194946.1NP_001181875.1  eukaryotic translation initiation factor 4 gamma 1 isoform 6

    See proteins identical to NP_001181875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.
    Source sequence(s)
    BC140892, BC140896, BQ011010, CR980540
    Consensus CDS
    CCDS54687.1
    UniProtKB/TrEMBL
    B2RU06
    UniProtKB/TrEMBL
    B2RU10
    Related
    ENSP00000371767, OTTHUMP00000210589, ENST00000382330, OTTHUMT00000345740
    Conserved Domains (5) summary
    pfam02847
    Location:12491361
    Blast Score: 341
    MA3; MA3 domain
    cd11559
    Location:14451577
    Blast Score: 499
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02854
    Location:768993
    Blast Score: 522
    MIF4G; MIF4G domain
    pfam08648
    Location:11441259
    Blast Score: 93
    DUF1777; Protein of unknown function (DUF1777)
    pfam09606
    Location:24459
    Blast Score: 137
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  2. NM_001194947.1NP_001181876.1  eukaryotic translation initiation factor 4 gamma 1 isoform 6

    See proteins identical to NP_001181876.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, includes an additional in-frame exon in the 5' coding region, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (6) is longer than isoform 1. Both variants 6 and 7 encode the same isoform.
    Source sequence(s)
    BC140896, BQ011010, CR980540
    Consensus CDS
    CCDS54687.1
    UniProtKB/TrEMBL
    B2RU10
    Related
    ENSP00000338020, ENST00000352767
    Conserved Domains (5) summary
    pfam02847
    Location:12491361
    Blast Score: 341
    MA3; MA3 domain
    cd11559
    Location:14451577
    Blast Score: 499
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02854
    Location:768993
    Blast Score: 522
    MIF4G; MIF4G domain
    pfam08648
    Location:11441259
    Blast Score: 93
    DUF1777; Protein of unknown function (DUF1777)
    pfam09606
    Location:24459
    Blast Score: 137
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
  3. NM_001291157.1NP_001278086.1  eukaryotic translation initiation factor 4 gamma 1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, includes an additional internal segment in the 5' region, which results in a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (7) is shorter at the N-terminus, and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AK226160, BG177454, DC369776
    Conserved Domains (4) summary
    pfam02847
    Location:12021314
    Blast Score: 341
    MA3; MA3 domain
    cd11559
    Location:13981530
    Blast Score: 497
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02854
    Location:721946
    Blast Score: 522
    MIF4G; MIF4G domain
    pfam08648
    Location:10971212
    Blast Score: 93
    DUF1777; Protein of unknown function (DUF1777)
  4. NM_004953.4NP_004944.3  eukaryotic translation initiation factor 4 gamma 1 isoform 4

    See proteins identical to NP_004944.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC078797, BQ011010
    Consensus CDS
    CCDS46970.2
    UniProtKB/Swiss-Prot
    Q04637
    Related
    ENSP00000411826, OTTHUMP00000233293, ENST00000434061, OTTHUMT00000345742
    Conserved Domains (4) summary
    pfam02847
    Location:10471159
    Blast Score: 339
    MA3; MA3 domain
    cd11559
    Location:12431375
    Blast Score: 490
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02854
    Location:566791
    Blast Score: 522
    MIF4G; MIF4G domain
    pfam08648
    Location:9421057
    Blast Score: 91
    DUF1777; Protein of unknown function (DUF1777)
  5. NM_182917.4NP_886553.3  eukaryotic translation initiation factor 4 gamma 1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AF002815, AK308319, AY082886, BQ011010, DC347118
    Consensus CDS
    CCDS54688.1
    UniProtKB/TrEMBL
    O95065
    UniProtKB/Swiss-Prot
    Q04637
    Related
    ENSP00000343450, OTTHUMP00000210577, ENST00000342981, OTTHUMT00000345727
    Conserved Domains (4) summary
    pfam02847
    Location:12431355
    Blast Score: 341
    MA3; MA3 domain
    cd11559
    Location:14391571
    Blast Score: 499
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02854
    Location:762987
    Blast Score: 522
    MIF4G; MIF4G domain
    pfam08648
    Location:11381253
    Blast Score: 94
    DUF1777; Protein of unknown function (DUF1777)
  6. NM_198241.2NP_937884.1  eukaryotic translation initiation factor 4 gamma 1 isoform 5

    See proteins identical to NP_937884.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (5) that is 1 aa shorter than isoform 1.
    Source sequence(s)
    BC007788, BQ011010, BX647812, CR980540
    Consensus CDS
    CCDS3259.1
    UniProtKB/Swiss-Prot
    Q04637
    UniProtKB/TrEMBL
    Q96I65
    Related
    ENSP00000316879, OTTHUMP00000210583, ENST00000346169, OTTHUMT00000345733
    Conserved Domains (4) summary
    pfam02847
    Location:12421354
    Blast Score: 341
    MA3; MA3 domain
    cd11559
    Location:14381570
    Blast Score: 499
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02854
    Location:761986
    Blast Score: 522
    MIF4G; MIF4G domain
    pfam08648
    Location:11371252
    Blast Score: 94
    DUF1777; Protein of unknown function (DUF1777)
  7. NM_198242.2NP_937885.1  eukaryotic translation initiation factor 4 gamma 1 isoform 3

    See proteins identical to NP_937885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AL832754, BM475154, BQ011010, CR980540, CX165113
    Consensus CDS
    CCDS3261.1
    UniProtKB/Swiss-Prot
    Q04637
    Related
    ENSP00000317600, OTTHUMP00000210585, ENST00000350481, OTTHUMT00000345735
    Conserved Domains (4) summary
    pfam02847
    Location:10781190
    Blast Score: 340
    MA3; MA3 domain
    cd11559
    Location:12741406
    Blast Score: 491
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02854
    Location:597822
    Blast Score: 522
    MIF4G; MIF4G domain
    pfam08648
    Location:9731088
    Blast Score: 90
    DUF1777; Protein of unknown function (DUF1777)
  8. NM_198244.2NP_937887.1  eukaryotic translation initiation factor 4 gamma 1 isoform 2

    See proteins identical to NP_937887.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, uses a downstream start codon, and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus and lacks an internal residue, compared to isoform 1.
    Source sequence(s)
    AK299763, BC007788, BC010688, BQ011010, CR980540
    Consensus CDS
    CCDS3260.1
    UniProtKB/TrEMBL
    B4DSI9
    UniProtKB/TrEMBL
    Q96I65
    Related
    ENSP00000376320, OTTHUMP00000210579, ENST00000392537, OTTHUMT00000345729
    Conserved Domains (4) summary
    pfam02847
    Location:11551267
    Blast Score: 341
    MA3; MA3 domain
    cd11559
    Location:13511483
    Blast Score: 496
    W2_eIF4G1_like; C-terminal W2 domain of eukaryotic translation initiation factor 4 gamma 1 and similar proteins
    pfam02854
    Location:674899
    Blast Score: 522
    MIF4G; MIF4G domain
    pfam08648
    Location:10501165
    Blast Score: 93
    DUF1777; Protein of unknown function (DUF1777)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000003.12 

    Range
    184314495..184335358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000135.1 

    Range
    181439248..181459772
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018914.2 

    Range
    183996741..184017602
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)