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BPIFB1 BPI fold containing family B, member 1 [ Homo sapiens (human) ]

Gene ID: 92747, updated on 13-Jan-2015
Official Symbol
BPIFB1provided by HGNC
Official Full Name
BPI fold containing family B, member 1provided by HGNC
Primary source
HGNC:HGNC:16108
Locus tag
RP5-1187J4.9
See related
Ensembl:ENSG00000125999; HPRD:12740; Vega:OTTHUMG00000032252
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LPLUNC1; C20orf114
Summary
The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]
Orthologs
See BPIFB1 in MapViewer
Location:
20q11.21
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 20 NC_000020.11 (33283135..33309878)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31870941..31897684)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene BPI fold containing family A, member 1 Neighboring gene ribosomal protein L12 pseudogene 3 Neighboring gene BPI fold containing family B, member 5, pseudogene Neighboring gene BPI fold containing family B, member 9, pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC14597

Gene Ontology Provided by GOA

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
innate immune response in mucosa IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
BPI fold-containing family B member 1
Names
BPI fold-containing family B member 1
VEMSGP
von Ebner minor salivary gland protein
long palate, lung and nasal epithelium carcinoma associated 1
long palate, lung and nasal epithelium carcinoma-associated protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033197.2NP_149974.2  BPI fold-containing family B member 1 precursor

    See proteins identical to NP_149974.2

    Status: REVIEWED

    Source sequence(s)
    AF364078, AW449208, CD696225
    Consensus CDS
    CCDS13218.1
    UniProtKB/Swiss-Prot
    Q8TDL5
    Related
    ENSP00000253354, OTTHUMP00000043374, ENST00000253354, OTTHUMT00000106499
    Conserved Domains (2) summary
    cd00025
    Location:26262
    BPI1; BPI/LBP/CETP N-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) N-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...
    cd00026
    Location:279474
    BPI2; BPI/LBP/CETP C-terminal domain; Bactericidal permeability-increasing protein (BPI) / Lipopolysaccharide-binding protein (LBP) / Cholesteryl ester transfer protein (CETP) C-terminal domain; binds to and neutralizes lipopolysaccharides from the outer ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 

    Range
    33283135..33309878
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 

    Range
    31771823..31798564
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 

    Range
    28658391..28685136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)