Display Settings:

Format

Send to:

Choose Destination

RRM2 ribonucleotide reductase M2 [ Homo sapiens (human) ]

Gene ID: 6241, updated on 7-Aug-2014
Official Symbol
RRM2provided by HGNC
Official Full Name
ribonucleotide reductase M2provided by HGNC
Primary source
HGNC:10452
See related
Ensembl:ENSG00000171848; HPRD:01587; MIM:180390; Vega:OTTHUMG00000090449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
R2; RR2; RR2M
Summary
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X. [provided by RefSeq, Sep 2009]
See RRM2 in Epigenomics, MapViewer
Location:
2p25-p24
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 2 NC_000002.12 (10122568..10131419)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10262695..10271546)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929882 Neighboring gene Kruppel-like factor 11 Neighboring gene cystin 1 Neighboring gene chromosome 2 open reading frame 48 Neighboring gene microRNA 4261 Neighboring gene uncharacterized LOC101929691

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with ribonucleotide reductase M2 (RRM2) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
 
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
 
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
DNA replication IEA
Inferred from Electronic Annotation
more info
 
G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
deoxyribonucleoside diphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 
deoxyribonucleotide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
nucleobase-containing small molecule interconversion TAS
Traceable Author Statement
more info
 
nucleobase-containing small molecule metabolic process TAS
Traceable Author Statement
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein heterotetramerization IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription involved in G1/S transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
Preferred Names
ribonucleoside-diphosphate reductase subunit M2
Names
ribonucleoside-diphosphate reductase subunit M2
ribonucleotide reductase small chain
ribonucleotide reductase small subunit
ribonucleotide reductase M2 polypeptide
NP_001025.1
NP_001159403.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034.3NP_001025.1  ribonucleoside-diphosphate reductase subunit M2 isoform 2

    See proteins identical to NP_001025.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternative downstream promoter, and it thus has a shorter 5' UTR and uses a downstream translational start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AC104794, AC118058, BM994533, X59618
    Consensus CDS
    CCDS1669.1
    UniProtKB/Swiss-Prot
    P31350
    Related
    ENSP00000302955, OTTHUMP00000220215, ENST00000304567, OTTHUMT00000364902
    Conserved Domains (1) summary
    cd01049
    Location:80355
    Blast Score: 1056
    RNRR2; Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain
  2. NM_001165931.1NP_001159403.1  ribonucleoside-diphosphate reductase subunit M2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC104794, AC118058, BM994533, DA477511, X59618
    Consensus CDS
    CCDS54334.1
    UniProtKB/Swiss-Prot
    P31350
    Related
    ENSP00000353770, OTTHUMP00000115511, ENST00000360566, OTTHUMT00000206895
    Conserved Domains (1) summary
    cd01049
    Location:140415
    Blast Score: 1093
    RNRR2; Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000002.12 

    Range
    10122568..10131419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000134.1 

    Range
    10113982..10122746
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 

    Range
    10192499..10201334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)