Display Settings:

Format

Send to:

Choose Destination
    • Showing Current items.

    PARK2 parkin RBR E3 ubiquitin protein ligase [ Homo sapiens (human) ]

    Gene ID: 5071, updated on 28-Jun-2015
    Official Symbol
    PARK2provided by HGNC
    Official Full Name
    parkin RBR E3 ubiquitin protein ligaseprovided by HGNC
    Primary source
    HGNC:HGNC:8607
    See related
    Ensembl:ENSG00000185345; HPRD:03967; MIM:602544; Vega:OTTHUMG00000015970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDJ; PRKN; AR-JP; LPRS2
    Summary
    The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support. [provided by RefSeq, Jul 2008]
    Orthologs
    See PARK2 in Epigenomics, MapViewer
    Location:
    6q25.2-q27
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 6 NC_000006.12 (161347417..162727802, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (161768590..163148834, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene AGPAT4 intronic transcript 1 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC105378094 Neighboring gene uncharacterized LOC105378098 Neighboring gene uncharacterized LOC105378097 Neighboring gene uncharacterized LOC105369171 Neighboring gene keratin 8 pseudogene 44 Neighboring gene transfer RNA-Glu (TTC) 15-1 Neighboring gene uncharacterized LOC105378096 Neighboring gene PARK2 co-regulated

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Leprosy 2
    MedGen: C1843632 OMIM: 607572 GeneReviews: Not available
    Compare labs
    Lung cancer
    MedGen: C0684249 OMIM: 211980 GeneReviews: Not available
    Compare labs
    Neoplasm of ovary
    MedGen: C0919267 OMIM: 167000 GeneReviews: Not available
    Compare labs
    Parkinson disease 2 Compare labs

    NHGRI GWAS Catalog

    Description
    A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
    NHGRI GWA Catalog
    Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum.
    NHGRI GWA Catalog
    Genome-wide association study of pancreatic cancer in Japanese population.
    NHGRI GWA Catalog
    Linkage and association of successful aging to the 6q25 region in large Amish kindreds.
    NHGRI GWA Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    NHGRI GWA Catalog
    Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.
    NHGRI GWA Catalog
    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • Alpha-synuclein signaling, organism-specific biosystem (from Pathway Interaction Database)
      Alpha-synuclein signaling, organism-specific biosystem
      Alpha-synuclein signaling
    • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
      Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
    • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
      Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystem (from WikiPathways)
      Parkin-Ubiquitin Proteasomal System pathway, organism-specific biosystemThis pathway describes the Parkin-Ubiquitin proteasome degradation system.
    • Parkinson's disease, organism-specific biosystem (from KEGG)
      Parkinson's disease, organism-specific biosystemParkinson's disease (PD) is a progressive neurodegenerative movement disorder that results primarily from the death of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Mutations...
    • Parkinsons Disease Pathway, organism-specific biosystem (from WikiPathways)
      Parkinsons Disease Pathway, organism-specific biosystemMost people with Parkinson's disease have idiopathic Parkinson's disease (having no specific known cause). A small proportion of cases, however, can be attributed to known genetic factors. Mutations ...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
      Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
      Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    F-box domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    G-protein coupled receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Hsp70 protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    SH3 domain binding TAS
    Traceable Author Statement
    more info
    PubMed 
    actin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    cullin family protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    tubulin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin protein ligase activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-specific protease binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    activation of mitophagy in response to mitochondrial depolarization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    activation of mitophagy in response to mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    adult locomotory behavior ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    aggresome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to dopamine TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to manganese ion TAS
    Traceable Author Statement
    more info
    PubMed 
    cellular response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to unfolded protein TAS
    Traceable Author Statement
    more info
    PubMed 
    central nervous system development TAS
    Traceable Author Statement
    more info
    PubMed 
    dopamine metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    dopamine uptake involved in synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    learning IEA
    Inferred from Electronic Annotation
    more info
     
    mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion degradation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion degradation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitochondrion degradation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    mitochondrion organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation by host of viral genome replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of actin filament bundle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell death IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of glucokinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mitochondrial fusion ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    negative regulation of neuron apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of neuron death IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of oxidative stress-induced cell death NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of oxidative stress-induced cell death TAS
    Traceable Author Statement
    more info
    PubMed 
    negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of primary amine oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of reactive oxygen species metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of release of cytochrome c from mitochondria IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of spontaneous neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron cellular homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    norepinephrine metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of dendrite extension IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mitochondrial fission ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    positive regulation of mitochondrial fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neurotransmitter uptake IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of proteasomal protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of protein linear polyubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteasomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K27-linked ubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    protein K29-linked ubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K6-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K6-linked ubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein K63-linked ubiquitination NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein K63-linked ubiquitination TAS
    Traceable Author Statement
    more info
    PubMed 
    protein autoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein localization to mitochondrion IEA
    Inferred from Electronic Annotation
    more info
     
    protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein ubiquitination involved in ubiquitin-dependent protein catabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of cellular response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    regulation of dopamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of dopamine secretion TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of glucose metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of lipid transport TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of mitochondrial membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of mitochondrion degradation TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of mitochondrion organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of mitochondrion organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of mitochondrion organization NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of protein targeting to mitochondrion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of protein ubiquitination IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of synaptic vesicle transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to oxidative stress ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    startle response IEA
    Inferred from Electronic Annotation
    more info
     
    synaptic transmission, glutamatergic IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    zinc ion homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with LUBAC complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Lewy body TAS
    Traceable Author Statement
    more info
    PubMed 
    Parkin-FBXW7-Cul1 ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT SCF ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    aggresome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    colocalizes_with mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neuron projection IEA
    Inferred from Electronic Annotation
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    E3 ubiquitin-protein ligase parkin
    Names
    E3 ubiquitin-protein ligase parkin
    Parkinson disease (autosomal recessive, juvenile) 2, parkin
    parkinson juvenile disease protein 2
    parkinson protein 2, E3 ubiquitin protein ligase (parkin)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008289.1 RefSeqGene

      Range
      5001..1385245
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004562.2NP_004553.2  E3 ubiquitin-protein ligase parkin isoform 1

      See identical proteins and their annotated locations for NP_004553.2

      Status: REVIEWED

      Description
      Transcript Variant: Transcript variant 1 represents the predominant and full-length form of this gene.
      Source sequence(s)
      AK292590, AL132982, DB023187
      Consensus CDS
      CCDS5281.1
      UniProtKB/Swiss-Prot
      O60260
      UniProtKB/TrEMBL
      X5DR79
      Related
      ENSP00000355865, OTTHUMP00000017565, ENST00000366898, OTTHUMT00000042995
      Conserved Domains (3) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:313375
      IBR; In Between Ring fingers
      pfam01485
      Location:412453
      IBR; IBR domain
    2. NM_013987.2NP_054642.2  E3 ubiquitin-protein ligase parkin isoform 2

      See identical proteins and their annotated locations for NP_054642.2

      Status: REVIEWED

      Description
      Transcript Variant: Transcript variant 2 lacks exons 5 which is present in the full-length variant 1.
      Source sequence(s)
      AK292590, AL132982, DB023187
      Consensus CDS
      CCDS5282.1
      UniProtKB/Swiss-Prot
      O60260
      Conserved Domains (3) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:285347
      IBR; In Between Ring fingers
      pfam01485
      Location:384425
      IBR; IBR domain
    3. NM_013988.2NP_054643.2  E3 ubiquitin-protein ligase parkin isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: Transcript variant 3 lacks exons 3 to 5 present in the full-length transcript variant 1.
      Source sequence(s)
      AK292590, AL132982, DB023187
      Consensus CDS
      CCDS5283.1
      UniProtKB/Swiss-Prot
      O60260
      Conserved Domains (3) summary
      cd01798
      Location:382
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00647
      Location:164226
      IBR; In Between Ring fingers
      pfam01485
      Location:263304
      IBR; IBR domain

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p2 Primary Assembly

      Range
      161347417..162727802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535863.1XP_011534165.1  

      Conserved Domains (4) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
      smart00647
      Location:312374
      IBR; In Between Ring fingers
      pfam01485
      Location:411452
      IBR; IBR domain
    2. XM_011535865.1XP_011534167.1  

      Conserved Domains (2) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
    3. XM_011535864.1XP_011534166.1  

      Related
      ENSP00000355858, OTTHUMP00000017563, ENST00000366892, OTTHUMT00000042993
      Conserved Domains (1) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
    4. XM_011535866.1XP_011534168.1  

      Conserved Domains (2) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues
    5. XM_011535867.1XP_011534169.1  

      Conserved Domains (2) summary
      cd01798
      Location:372
      parkin_N; amino-terminal ubiquitin-like of parkin protein
      smart00213
      Location:172
      UBQ; Ubiquitin homologues

    Alternate CHM1_1.1

    Genomic

    1. NC_018917.2 Alternate CHM1_1.1

      Range
      162031091..163411071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)