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    KMT2C lysine (K)-specific methyltransferase 2C [ Homo sapiens (human) ]

    Gene ID: 58508, updated on 18-Jul-2015
    Official Symbol
    KMT2Cprovided by HGNC
    Official Full Name
    lysine (K)-specific methyltransferase 2Cprovided by HGNC
    Primary source
    HGNC:HGNC:13726
    See related
    Ensembl:ENSG00000055609; HPRD:06016; MIM:606833; Vega:OTTHUMG00000150553
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HALR; MLL3
    Summary
    This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
    Orthologs
    See KMT2C in Epigenomics, MapViewer
    Location:
    7q36.1
    Exon count:
    64
    Annotation release Status Assembly Chr Location
    107 current GRCh38.p2 (GCF_000001405.28) 7 NC_000007.14 (152134925..152436638, complement)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (151832010..152133090, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 11 Neighboring gene uncharacterized LOC105375572 Neighboring gene uncharacterized LOC731075 Neighboring gene Y box binding protein 1 pseudogene 4 Neighboring gene septin 7 pseudogene 6 Neighboring gene fatty acid binding protein 5 pseudogene 3 Neighboring gene chaperonin containing TCP1, subunit 8 (theta)-like 1, pseudogene

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • FLJ12625, FLJ38309, KIAA1506, MGC119851, MGC119852, MGC119853, DKFZp686C08112

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    histone methyltransferase activity (H3-K4 specific) IDA
    Inferred from Direct Assay
    more info
    PubMed 
    poly(A) RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    chromatin organization TAS
    Traceable Author Statement
    more info
     
    histone H3-K4 methylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    histone methyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    histone-lysine N-methyltransferase 2C
    Names
    ALR-like protein
    histone-lysine N-methyltransferase MLL3
    histone-lysine N-methyltransferase, H3 lysine-4 specific
    homologous to ALR protein
    myeloid/lymphoid or mixed-lineage leukemia protein 3
    NP_733751.2

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_033948.1 RefSeqGene

      Range
      5001..306081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170606.2NP_733751.2  histone-lysine N-methyltransferase 2C

      See identical proteins and their annotated locations for NP_733751.2

      Status: REVIEWED

      Source sequence(s)
      AF264750, AK025911, AY024361, BP281562, BU623509, BU685177, CD513584
      Consensus CDS
      CCDS5931.1
      UniProtKB/Swiss-Prot
      Q8NEZ4
      Related
      ENSP00000262189, OTTHUMP00000197821, ENST00000262189, OTTHUMT00000318887
      Conserved Domains (16) summary
      smart00317
      Location:47724893
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:48954911
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47254911
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16551703
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31783270
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:45504604
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46064691
      FYRC; F/Y rich C-terminus
      sd00025
      Location:980983
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:343388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10091055
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9521008
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10861136
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44024506
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p2 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p2 Primary Assembly

      Range
      152134925..152436638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005250025.3XP_005250082.1  

      Conserved Domains (16) summary
      smart00317
      Location:48444965
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49674983
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47974983
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16721720
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31953287
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:46224676
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46784763
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44744578
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    2. XM_005250026.2XP_005250083.1  

      Conserved Domains (16) summary
      smart00317
      Location:48434964
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49664982
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47964982
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16711719
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31943286
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:46214675
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46774762
      FYRC; F/Y rich C-terminus
      sd00025
      Location:980983
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:343388
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:466517
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10091055
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:390435
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9521008
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10861136
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:247330
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44734577
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    3. XM_011516451.1XP_011514753.1  

      Conserved Domains (16) summary
      smart00317
      Location:48044925
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49274943
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47574943
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16321680
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31553247
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:45824636
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46384723
      FYRC; F/Y rich C-terminus
      sd00025
      Location:941944
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:9701016
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:913969
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10471097
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44344538
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    4. XM_011516452.1XP_011514754.1  

      Conserved Domains (16) summary
      smart00317
      Location:47934914
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49164932
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47464932
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16211669
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31443236
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:45714625
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46274712
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44234527
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    5. XM_011516456.1XP_011514758.1  

      Conserved Domains (16) summary
      smart00317
      Location:48244945
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49474963
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47644963
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16561704
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31793271
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:46064660
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46624747
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44584562
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    6. XM_011516450.1XP_011514752.1  

      Conserved Domains (16) summary
      smart00317
      Location:48284949
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49514967
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47814967
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16561704
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31793271
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:46064660
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46624747
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44584562
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    7. XM_011516453.1XP_011514755.1  

      Conserved Domains (16) summary
      smart00317
      Location:47654886
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:48884904
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47184904
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16721720
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31953287
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:45434597
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:45994684
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:43954499
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    8. XM_006716079.2XP_006716142.1  

      Conserved Domains (16) summary
      smart00317
      Location:47884909
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49114927
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47414927
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16721720
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31953287
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:45664620
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46224707
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44184522
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    9. XM_005250031.3XP_005250088.1  

      Conserved Domains (16) summary
      smart00317
      Location:47894910
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49124928
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47424928
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16721720
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31953287
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:45674621
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46234708
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44194523
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    10. XM_005250027.3XP_005250084.1  

      Conserved Domains (16) summary
      smart00317
      Location:48434964
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49664982
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47964982
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16721720
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31953287
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:46214675
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46774762
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44734577
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    11. XM_006716078.2XP_006716141.1  

      Conserved Domains (16) summary
      smart00317
      Location:48204941
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49434959
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47734959
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16721720
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31953287
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:45984652
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46544739
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44504554
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    12. XM_006716077.2XP_006716140.1  

      Conserved Domains (16) summary
      smart00317
      Location:48434964
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49664982
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47964982
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16721720
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31953287
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:46214675
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46774762
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44734577
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    13. XM_005250028.3XP_005250085.1  

      Conserved Domains (16) summary
      smart00317
      Location:48404961
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:49634979
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:47804979
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:16721720
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:31953287
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:46224676
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:46784763
      FYRC; F/Y rich C-terminus
      sd00025
      Location:981984
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:344389
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:467518
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:10101056
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:391436
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:9531009
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:10871137
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15696
      Location:248331
      ePHD1_KMT2C; Extended PHD finger 1 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:44744578
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
    14. XM_011516454.1XP_011514756.1  

      Conserved Domains (16) summary
      smart00317
      Location:45394660
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:46624678
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:44924678
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:13671415
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:28902982
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:43174371
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:43734458
      FYRC; F/Y rich C-terminus
      sd00025
      Location:676679
      zf-RanBP2; Zn binding site [ion binding]
      cd15509
      Location:3984
      PHD1_KMT2C_like; PHD finger 1 found in Histone-lysine N-methyltransferase 2C (KMT2C) and 2D (KMT2D)
      cd15511
      Location:162213
      PHD3_KMT2C; PHD finger 3 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15513
      Location:705751
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15594
      Location:86131
      PHD2_KMT2C; PHD finger 2 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15596
      Location:648704
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:782832
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:41694273
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)
      cl22851
      Location:126
      PHD_SF; PHD finger superfamily
    15. XM_011516455.1XP_011514757.1  

      Conserved Domains (12) summary
      smart00317
      Location:40264147
      SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
      smart00508
      Location:41494165
      PostSET; Cysteine-rich motif following a subset of SET domains
      COG2940
      Location:39794165
      SET; SET domain-containing protein (function unknown) [General function prediction only]
      cd01390
      Location:854902
      HMGB-UBF_HMG-box; HMGB-UBF_HMG-box, class II and III members of the HMG-box superfamily of DNA-binding proteins. These proteins bind the minor groove of DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone ...
      pfam01920
      Location:23772469
      Prefoldin_2; Prefoldin subunit
      pfam05964
      Location:38043858
      FYRN; F/Y-rich N-terminus
      pfam05965
      Location:38603945
      FYRC; F/Y rich C-terminus
      sd00025
      Location:163166
      zf-RanBP2; Zn binding site [ion binding]
      cd15513
      Location:192238
      PHD5_KMT2C_like; PHD finger 5 found in Histone-lysine N-methyltransferase 2C (KMT2C) and PHD finger 4 found in KMT2D
      cd15596
      Location:135191
      PHD4_KMT2C; PHD finger 4 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15600
      Location:269319
      PHD6_KMT2C; PHD finger 6 found in Histone-lysine N-methyltransferase 2C (KMT2C)
      cd15697
      Location:36563760
      ePHD2_KMT2C; Extended PHD finger 2 found in histone-lysine N-methyltransferase 2C (KMT2C)

    RNA

    1. XR_428183.2 RNA Sequence

    Alternate CHM1_1.1

    Genomic

    1. NC_018918.2 Alternate CHM1_1.1

      Range
      151840538..152142092
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_021230.2: Suppressed sequence

      Description
      NM_021230.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.