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IL5 interleukin 5 [ Homo sapiens (human) ]

Gene ID: 3567, updated on 11-Sep-2014
Official Symbol
IL5provided by HGNC
Official Full Name
interleukin 5provided by HGNC
Primary source
HGNC:HGNC:6016
See related
Ensembl:ENSG00000113525; HPRD:00997; MIM:147850; Vega:OTTHUMG00000059496
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EDF; TRF; IL-5
Summary
This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
Location:
5q31.1
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 5 NC_000005.10 (132541444..132556863, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (131877136..131892555, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102723741 Neighboring gene chromosome 5 open reading frame 56 Neighboring gene interferon regulatory factor 1 Neighboring gene RAD50 homolog (S. cerevisiae) Neighboring gene uncharacterized LOC101927761 Neighboring gene interleukin 13

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.
NHGRI GWA Catalog
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Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
interleukin-5 receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
immune response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JAK-STAT cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of eosinophil differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of immunoglobulin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of podosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of sequence-specific DNA binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region IDA
Inferred from Direct Assay
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space TAS
Traceable Author Statement
more info
PubMed 
Preferred Names
interleukin-5
Names
interleukin-5
T-cell replacing factor
B-cell differentiation factor I
eosinophil differentiation factor
colony-stimulating factor, eosinophil

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033019.1 

    Range
    5001..7079
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000879.2NP_000870.1  interleukin-5 precursor

    See proteins identical to NP_000870.1

    Status: REVIEWED

    Source sequence(s)
    X04688
    Consensus CDS
    CCDS4156.1
    UniProtKB/Swiss-Prot
    P05113
    Related
    ENSP00000231454, OTTHUMP00000065830, ENST00000231454, OTTHUMT00000132339
    Conserved Domains (1) summary
    pfam02025
    Location:21133
    IL5; Interleukin 5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000005.10 

    Range
    132541444..132556863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714601.1XP_006714664.1  

    Conserved Domains (1) summary
    pfam02025
    Location:62174
    IL5; Interleukin 5
  2. XM_005271988.1XP_005272045.1  

    Conserved Domains (1) summary
    pfam02025
    Location:43155
    IL5; Interleukin 5

Alternate HuRef

Genomic

  1. AC_000137.1 

    Range
    127069401..127071479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018916.2 

    Range
    131310410..131312488
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)