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    Atr ataxia telangiectasia and Rad3 related [ Mus musculus (house mouse) ]

    Gene ID: 245000, updated on 27-Aug-2016
    Official Symbol
    Atrprovided by MGI
    Official Full Name
    ataxia telangiectasia and Rad3 relatedprovided by MGI
    Primary source
    MGI:MGI:108028
    See related
    Ensembl:ENSMUSG00000032409 Vega:OTTMUSG00000047295
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Orthologs
    Location:
    9; 9 E4
    Exon count:
    47
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (95857597..95953217)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (95758016..95852063)

    Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39407 Neighboring gene transient receptor potential cation channel, subfamily C, member 1 Neighboring gene plastin 1 (I-isoform) Neighboring gene RIKEN cDNA 1700065D16 gene Neighboring gene predicted gene, 16794 Neighboring gene 5'-3' exoribonuclease 1 Neighboring gene glycerol kinase 5 (putative)

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    MutLalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    MutSalpha complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    DNA damage checkpoint ISO
    Inferred from Sequence Orthology
    more info
     
    DNA repair IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to UV ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to gamma radiation ISO
    Inferred from Sequence Orthology
    more info
     
    establishment of RNA localization to telomere ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
     
    peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of DNA damage response, signal transduction by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomerase catalytic core complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein localization to chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    replicative senescence ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    PML body ISO
    Inferred from Sequence Orthology
    more info
     
    XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus TAS
    Traceable Author Statement
    more info
    PubMed 
    Preferred Names
    serine/threonine-protein kinase ATR
    Names
    ataxia telangiectasia and Rad3-related protein
    NP_063917.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019864.1NP_063917.1  serine/threonine-protein kinase ATR

      Status: VALIDATED

      Source sequence(s)
      AC091531, AC121499
      Consensus CDS
      CCDS52890.1
      UniProtKB/TrEMBL
      E9QPK4
      Related
      ENSMUSP00000034980, OTTMUSP00000067136, ENSMUST00000034980, OTTMUST00000122282
      Conserved Domains (7) summary
      smart00802
      Location:11191225
      UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
      COG5032
      Location:21232641
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      cd00892
      Location:22902564
      PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
      pfam02259
      Location:17712092
      FAT; FAT domain
      pfam02260
      Location:26102641
      FATC; FATC domain
      sd00044
      Location:690720
      HEAT; HEAT repeat [structural motif]
      cl11397
      Location:15291607
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

      Range
      95857597..95953217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511184.3XP_006511247.1  

      Conserved Domains (6) summary
      smart00802
      Location:11191225
      UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
      COG5032
      Location:21172635
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      pfam02259
      Location:17652086
      FAT; FAT domain
      pfam02260
      Location:26032635
      FATC; FATC domain
      cl11397
      Location:15291607
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      cd00892
      Location:22842558
      PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins
    2. XM_011242749.1XP_011241051.1  

      Conserved Domains (1) summary
      smart00802
      Location:11191225
      UME; Domain in UVSB PI-3 kinase, MEI-41 and ESR-1
    3. XM_006511188.3XP_006511251.1  

      Conserved Domains (5) summary
      COG5032
      Location:8291347
      TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
      pfam02259
      Location:477798
      FAT; FAT domain
      pfam02260
      Location:13151347
      FATC; FATC domain
      cl11397
      Location:241319
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
      cd00892
      Location:9961270
      PIKKc_ATR; Catalytic domain of Ataxia telangiectasia and Rad3-related proteins

    RNA

    1. XR_001778905.1 RNA Sequence

    2. XR_001778904.1 RNA Sequence

    3. XR_001778906.1 RNA Sequence