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Chrnb2 cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal) [ Mus musculus (house mouse) ]

Gene ID: 11444, updated on 23-Dec-2014
Official Symbol
Chrnb2provided by MGI
Official Full Name
cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)provided by MGI
Primary source
MGI:MGI:87891
See related
Ensembl:ENSMUSG00000027950
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Acrb2; Acrb-2; [b]2-nAchR; C030030P04Rik
See Chrnb2 in Epigenomics, MapViewer
Location:
3 F1; 3 39.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 3 NC_000069.6 (89753448..89764632, complement)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene phosphomevalonate kinase Neighboring gene potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3 Neighboring gene adenosine deaminase, RNA-specific Neighboring gene ubiquitin-conjugating enzyme E2Q (putative) 1 Neighboring gene predicted gene 8969

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
acetylcholine binding ISO
Inferred from Sequence Orthology
more info
 
acetylcholine receptor activity ISO
Inferred from Sequence Orthology
more info
 
acetylcholine-activated cation-selective channel activity IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine-activated cation-selective channel activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acetylcholine-activated cation-selective channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acetylcholine-activated cation-selective channel activity ISO
Inferred from Sequence Orthology
more info
 
drug binding ISO
Inferred from Sequence Orthology
more info
 
extracellular ligand-gated ion channel activity IEA
Inferred from Electronic Annotation
more info
 
ion channel activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
B cell activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
action potential IGI
Inferred from Genetic Interaction
more info
PubMed 
action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
associative learning IGI
Inferred from Genetic Interaction
more info
PubMed 
behavioral response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
behavioral response to nicotine ISO
Inferred from Sequence Orthology
more info
 
calcium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
cation transmembrane transport IGI
Inferred from Genetic Interaction
more info
PubMed 
cation transmembrane transport ISO
Inferred from Sequence Orthology
more info
 
central nervous system neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system projection neuron axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cognition ISO
Inferred from Sequence Orthology
more info
 
conditioned taste aversion IMP
Inferred from Mutant Phenotype
more info
PubMed 
ion transport IEA
Inferred from Electronic Annotation
more info
 
lateral geniculate nucleus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
learning ISO
Inferred from Sequence Orthology
more info
 
locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
memory ISO
Inferred from Sequence Orthology
more info
 
negative regulation of action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
neurological system process ISO
Inferred from Sequence Orthology
more info
 
optic nerve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of B cell proliferation IC
Inferred by Curator
more info
PubMed 
positive regulation of B cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dopamine secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein heterooligomerization ISO
Inferred from Sequence Orthology
more info
 
regulation of circadian sleep/wake cycle, REM sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of circadian sleep/wake cycle, non-REM sleep IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of dopamine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane potential IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of membrane potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of synaptic transmission, dopaminergic IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to cocaine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to ethanol IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
response to nicotine IGI
Inferred from Genetic Interaction
more info
PubMed 
response to nicotine IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to nicotine ISO
Inferred from Sequence Orthology
more info
 
sensory perception of pain IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction ISO
Inferred from Sequence Orthology
more info
 
smooth muscle contraction IGI
Inferred from Genetic Interaction
more info
PubMed 
social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptic transmission involved in micturition IGI
Inferred from Genetic Interaction
more info
PubMed 
synaptic transmission, cholinergic ISO
Inferred from Sequence Orthology
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
vestibulocochlear nerve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
visual learning ISO
Inferred from Sequence Orthology
more info
 
visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
acetylcholine-gated channel complex IDA
Inferred from Direct Assay
more info
PubMed 
acetylcholine-gated channel complex ISO
Inferred from Sequence Orthology
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
neuronal acetylcholine receptor subunit beta-2
Names
neuronal acetylcholine receptor subunit beta-2
acetylcholine receptor beta 2 neural

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009602.4NP_033732.2  neuronal acetylcholine receptor subunit beta-2 precursor

    See proteins identical to NP_033732.2

    Status: VALIDATED

    Source sequence(s)
    AK051742, BC065103, BY123599
    Consensus CDS
    CCDS17515.1
    UniProtKB/Swiss-Prot
    Q9ERK7
    Related
    ENSMUSP00000029562, ENSMUST00000029562
    Conserved Domains (3) summary
    TIGR00860
    Location:29478
    LIC; Cation transporter family protein
    pfam02931
    Location:29234
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:241477
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000069.6 

    Range
    89753448..89764632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500916.1XP_006500979.1  

    Conserved Domains (2) summary
    pfam02931
    Location:2174
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:181417
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

Alternate Mm_Celera

Genomic

  1. AC_000025.1 

    Range
    89790490..89801674
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)