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    Mapk14 mitogen-activated protein kinase 14 [ Mus musculus (house mouse) ]

    Gene ID: 26416, updated on 17-Jul-2016
    Official Symbol
    Mapk14provided by MGI
    Official Full Name
    mitogen-activated protein kinase 14provided by MGI
    Primary source
    MGI:MGI:1346865
    See related
    Ensembl:ENSMUSG00000053436 Vega:OTTMUSG00000020086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    p38; Crk1; Mxi2; p38a; CSBP2; Csbp1; PRKM14; PRKM15; p38MAPK; p38alpha; p38-alpha
    Orthologs
    Location:
    17 A3.3; 17 14.85 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (28691342..28748405)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (28828287..28885350)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene serine/arginine-rich protein specific kinase 1 Neighboring gene solute carrier family 26, member 8 Neighboring gene guanine nucleotide binding protein (G protein), gamma 5 pseudogene Neighboring gene mitogen-activated protein kinase 13 Neighboring gene uncharacterized LOC105246245 Neighboring gene bromodomain and PHD finger containing, 3

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Clone Names

    • MGC102436

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATP binding ISO
    Inferred from Sequence Orthology
    more info
     
    MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    NFAT protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    DNA damage checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage condensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cellular response to ionizing radiation ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to lipopolysaccharide ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    cellular response to vascular endothelial growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    chondrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fatty acid oxidation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    glucose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
     
    lipopolysaccharide-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myoblast differentiation involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    p38MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    placenta development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of brown fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cardiac muscle cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cyclase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of erythrocyte differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of glucose import IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of interleukin-12 secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of myoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myoblast fusion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of reactive oxygen species metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    protein autophosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of ossification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to lipopolysaccharide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to muramyl dipeptide IDA
    Inferred from Direct Assay
    more info
    PubMed 
    response to muscle stretch IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    signal transduction in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
     
    skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    stress-induced premature senescence ISO
    Inferred from Sequence Orthology
    more info
     
    striated muscle cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    transmembrane receptor protein serine/threonine kinase signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    vascular endothelial growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    mitogen-activated protein kinase 14
    Names
    MAP kinase 14
    MAP kinase p38 alpha
    MAPK 14
    cytokine suppressive anti-inflammatory drug binding protein 1
    mitogen activated protein kinase 14
    mitogen-activated protein kinase p38 alpha
    p38 MAP kinase alpha
    p38 MAPK
    p38 alpha
    tRNA synthetase cofactor p38
    NP_001161980.1
    NP_001161985.1
    NP_001161986.1
    NP_036081.1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168508.1NP_001161980.1  mitogen-activated protein kinase 14 isoform 2

      See identical proteins and their annotated locations for NP_001161980.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame coding exon compared to variant 1. This results in an isoform (2) of the same size, but with a different 27 aa protein segment compared to isoform 1.
      Source sequence(s)
      AC170998, AI132714, AK133684, CX568915, D83073
      Consensus CDS
      CCDS50048.1
      UniProtKB/Swiss-Prot
      P47811
      UniProtKB/TrEMBL
      Q5U421
      Related
      ENSMUSP00000004990, OTTMUSP00000021705, ENSMUST00000004990, OTTMUST00000047771
      Conserved Domains (2) summary
      cd07877
      Location:6350
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
      smart00220
      Location:24308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
    2. NM_001168513.1NP_001161985.1  mitogen-activated protein kinase 14 isoform 3

      See identical proteins and their annotated locations for NP_001161985.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate 5' terminal exon compared to variant 1. This results in translation initiation from an in-frame downstream AUG and a shorter isoform (3) compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AI132714, AK133684, AK151348
      Consensus CDS
      CCDS50049.1
      UniProtKB/Swiss-Prot
      P47811
      Related
      ENSMUSP00000110400, OTTMUSP00000021709, ENSMUST00000114752, OTTMUST00000047775
      Conserved Domains (2) summary
      smart00220
      Location:1231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1273
      PKc_like; Protein Kinases, catalytic domain
    3. NM_001168514.1NP_001161986.1  mitogen-activated protein kinase 14 isoform 3

      See identical proteins and their annotated locations for NP_001161986.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) contains an additional exon at the 5' end compared to variant 1. This results in translation initiation from an in-frame downstream AUG and a shorter isoform (3) compared to isoform 1. Variants 3 and 4 encode the same isoform (3).
      Source sequence(s)
      AC170998, AI132714, AK133684
      Consensus CDS
      CCDS50049.1
      UniProtKB/Swiss-Prot
      P47811
      Related
      ENSMUSP00000110402, OTTMUSP00000021707, ENSMUST00000114754, OTTMUST00000047773
      Conserved Domains (2) summary
      smart00220
      Location:1231
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1273
      PKc_like; Protein Kinases, catalytic domain
    4. NM_011951.3NP_036081.1  mitogen-activated protein kinase 14 isoform 1

      See identical proteins and their annotated locations for NP_036081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC170998, AI132714, AK133684
      Consensus CDS
      CCDS28583.1
      UniProtKB/Swiss-Prot
      P47811
      Related
      ENSMUSP00000061958, OTTMUSP00000021706, ENSMUST00000062694, OTTMUST00000047772
      Conserved Domains (2) summary
      cd07877
      Location:6350
      STKc_p38alpha; Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14)
      smart00220
      Location:24308
      S_TKc; Serine/Threonine protein kinases, catalytic domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      28691342..28748405
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017317480.1XP_017172969.1  

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187005.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      1382527..1438986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)