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    KIF11 kinesin family member 11 [ Homo sapiens (human) ]

    Gene ID: 3832, updated on 25-Aug-2016
    Official Symbol
    KIF11provided by HGNC
    Official Full Name
    kinesin family member 11provided by HGNC
    Primary source
    HGNC:HGNC:6388
    See related
    Ensembl:ENSG00000138160 HPRD:01023; MIM:148760; Vega:OTTHUMG00000018761
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EG5; HKSP; KNSL1; MCLMR; TRIP5
    Summary
    This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis. [provided by RefSeq, Jul 2008]
    Orthologs
    Location:
    10q24.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    108 current GRCh38.p7 (GCF_000001405.33) 10 NC_000010.11 (92593068..92655395)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (94352825..94415152)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene microtubule affinity regulating kinase 2 pseudogene 9 Neighboring gene insulin degrading enzyme Neighboring gene ribosomal protein L11 pseudogene 4 Neighboring gene eukaryotic translation initiation factor 2 subunit 2 beta pseudogene 3 Neighboring gene hematopoietically expressed homeobox

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Associated conditions

    Description Tests
    Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation
    MedGen: C1835265 OMIM: 152950 GeneReviews: Not available
    Compare labs

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated (2013-08-01)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated (2013-08-01)

    ClinGen Genome Curation PagePubMed

    NHGRI GWAS Catalog

    Description
    Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
    NHGRI GWA Catalog

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat modulates EG5 activity allosterically by blocking ADP release from EG5. Residue K85 in EG5 is important for Tat-mediated suppression of EG5 activity and Tat-induced apoptosis during mitotic arrest PubMed
    tat Pull-down/immunoprecipitation assays demonstrate that HIV-1 Tat interacts with EG5 in cells. The carboxyl-terminal domain (residues 73-101) of Tat and the amino-terminal half (residues 1-517) of EG5 are involved in the interaction between Tat and EG5 PubMed

    Go to the HIV-1, Human Interaction Database

    • Adaptive Immune System, organism-specific biosystem (from REACTOME)
      Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
    • COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystem (from REACTOME)
      COPI-dependent Golgi-to-ER retrograde traffic, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER is mediated in part by microtubule-directed COPI-coated vesicles (Letourneur et al, 1994; Shima et al, 1999; Spang et al, 1998; reviewed i...
    • Factors involved in megakaryocyte development and platelet production, organism-specific biosystem (from REACTOME)
      Factors involved in megakaryocyte development and platelet production, organism-specific biosystemMegakaryocytes (MKs) give rise to circulating platelets (thrombocytes) through terminal differentiation of MKs which release cytoplasmic fragments as circulating platelets. As MKs mature they underg...
    • Golgi-to-ER retrograde transport, organism-specific biosystem (from REACTOME)
      Golgi-to-ER retrograde transport, organism-specific biosystemRetrograde traffic from the cis-Golgi to the ERGIC or the ER occurs through either COPI-coated vesicles or through a less well characterized RAB6-dependent route that makes use of tubular carriers (r...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
      Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
    • Kinesins, organism-specific biosystem (from REACTOME)
      Kinesins, organism-specific biosystemKinesins are a superfamily of microtubule-based motor proteins that have diverse functions in transport of vesicles, organelles and chromosomes, and regulate microtubule dynamics. There are 14 famil...
    • MHC class II antigen presentation, organism-specific biosystem (from REACTOME)
      MHC class II antigen presentation, organism-specific biosystemAntigen presenting cells (APCs) such as B cells, dendritic cells (DCs) and monocytes/macrophages express major histocompatibility complex class II molecules (MHC II) at their surface and present exog...
    • Membrane Trafficking, organism-specific biosystem (from REACTOME)
      Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
    • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
      Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    ATP-dependent microtubule motor activity, plus-end-directed IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    microtubule motor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    protein complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
    Traceable Author Statement
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    microtubule-based movement TAS
    Traceable Author Statement
    more info
     
    mitotic centrosome separation IEA
    Inferred from Electronic Annotation
    more info
     
    mitotic nuclear division TAS
    Traceable Author Statement
    more info
    PubMed 
    mitotic spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mitotic spindle organization TAS
    Traceable Author Statement
    more info
    PubMed 
    regulation of mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    retrograde vesicle-mediated transport, Golgi to ER TAS
    Traceable Author Statement
    more info
     
    spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
     
    cytosol TAS
    Traceable Author Statement
    more info
     
    kinesin complex TAS
    Traceable Author Statement
    more info
    PubMed 
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with spindle microtubule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with spindle pole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    kinesin-like protein KIF11
    Names
    TR-interacting protein 5
    TRIP-5
    kinesin-like protein 1
    kinesin-like spindle protein HKSP
    kinesin-related motor protein Eg5
    thyroid receptor-interacting protein 5

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032580.1 RefSeqGene

      Range
      5001..67328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004523.3NP_004514.2  kinesin-like protein KIF11

      See identical proteins and their annotated locations for NP_004514.2

      Status: REVIEWED

      Source sequence(s)
      AA504625, BC136474, BM742618, CU446438, DB078134
      Consensus CDS
      CCDS7422.1
      UniProtKB/Swiss-Prot
      P52732
      Related
      ENSP00000260731, OTTHUMP00000020099, ENST00000260731, OTTHUMT00000049401
      Conserved Domains (3) summary
      smart00129
      Location:18366
      KISc; Kinesin motor, catalytic domain. ATPase
      pfam13931
      Location:9161054
      Microtub_bind; Kinesin-associated microtubule-binding
      cd01364
      Location:16368
      KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 108 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p7 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p7 Primary Assembly

      Range
      92593068..92655395
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.1

    Genomic

    1. NC_018921.2 Alternate CHM1_1.1

      Range
      94634851..94697127
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)