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    Shh sonic hedgehog [ Mus musculus (house mouse) ]

    Gene ID: 20423, updated on 24-Jun-2016
    Official Symbol
    Shhprovided by MGI
    Official Full Name
    sonic hedgehogprovided by MGI
    Primary source
    MGI:MGI:98297
    See related
    Ensembl:ENSMUSG00000002633 Vega:OTTMUSG00000021299
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hx; Dsh; Hhg1; Hxl3; M100081; 9530036O11Rik
    Orthologs
    Location:
    5 B1; 5 14.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (28456840..28467101, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (28783380..28793641, complement)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35602 Neighboring gene RNA binding motif protein 33 Neighboring gene RIKEN cDNA 9530036O11Rik Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 42243

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Spontaneous (1) 
    • Targeted (20)  1 citation
    • Chemically induced (ENU) (8)  1 citation
    • Radiation induced (1) 
    Products Interactant Other Gene Complex Source Pubs Description

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    glycoprotein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glycosaminoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT hydrolase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    laminin-1 binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    patched binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    patched binding ISO
    Inferred from Sequence Orthology
    more info
     
    peptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    Bergmann glial cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    CD4-positive or CD8-positive, alpha-beta T cell lineage commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    CD4-positive or CD8-positive, alpha-beta T cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
     
    T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anatomical structure development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anatomical structure formation involved in morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    androgen metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    anterior/posterior pattern specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    artery development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    artery development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    axon guidance IDA
    Inferred from Direct Assay
    more info
    PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    blood coagulation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in prostate gland morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    branching involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching involved in ureteric bud morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    bud outgrowth involved in lung branching IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    camera-type eye development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    camera-type eye development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    camera-type eye development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell fate commitment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell fate specification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    cell proliferation in external granule layer IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell-cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to lithium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebellar granule cell precursor proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cerebellar granule cell precursor proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    determination of left/right asymmetry in lateral mesoderm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    developmental growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    digestive tract mesoderm development ISO
    Inferred from Sequence Orthology
    more info
     
    digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dopaminergic neuron differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    dorsal/ventral neural tube patterning IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dorsal/ventral neural tube patterning IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    dorsal/ventral neural tube patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    dorsal/ventral pattern formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    ectoderm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryo development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryo development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic digestive tract morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    embryonic digit morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic foregut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic limb morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    embryonic limb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic organ development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    embryonic skeletal system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    endocytosis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    epithelial cell proliferation involved in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial tube branching involved in lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial-mesenchymal cell signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    epithelial-mesenchymal signaling involved in prostate gland development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    epithelial-mesenchymal signaling involved in prostate gland development ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    establishment of cell polarity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    forebrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    forebrain regionalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    formation of anatomical boundary IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    fungiform papilla development ISO
    Inferred from Sequence Orthology
    more info
     
    fungiform papilla formation ISO
    Inferred from Sequence Orthology
    more info
     
    fungiform papilla morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hair follicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    heart looping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hindbrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    hindbrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    inner ear development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    inner ear development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    intein-mediated protein splicing IEA
    Inferred from Electronic Annotation
    more info
     
    intermediate filament organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    kidney development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    left lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    limb development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung epithelium development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung lobe morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lung-associated mesenchyme development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphoid progenitor cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    lymphoid progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    male genitalia development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    male genitalia morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    mesenchymal cell proliferation involved in lung development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    mesenchymal smoothened signaling pathway involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephric mesenchymal cell proliferation involved in metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    metanephros development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    midbrain development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    multicellular structure septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    myoblast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    myotube differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of cholesterol efflux IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of kidney smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of mesenchymal cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of transcription elongation from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of ureter smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural crest cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neural tube formation ISO
    Inferred from Sequence Orthology
    more info
     
    neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    odontogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    odontogenesis of dentin-containing tooth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    oligodendrocyte development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    organ formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    osteoblast development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    palate development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pancreas development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    pattern specification process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    pattern specification process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    patterning of blood vessels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    polarity specification of anterior/posterior axis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of T cell differentiation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of alpha-beta T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cerebellar granule cell precursor proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of hh target transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of hh target transcription factor activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of hh target transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of immature T cell proliferation in thymus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of kidney smooth muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of mesenchymal cell proliferation involved in ureter development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of neuroblast proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of neuroblast proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of oligodendrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of oligodendrocyte progenitor proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of penile erection ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of photoreceptor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein import into nucleus IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of sclerotome development ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of skeletal muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of skeletal muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of striated muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    positive regulation of transcription from RNA polymerase II promoter IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of transcription, DNA-templated IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription, DNA-templated ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ureter smooth muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive thymic T cell selection IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    primary prostatic bud elongation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostate epithelial cord elongation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT prostatic bud formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    protein localization to nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of epithelial cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    regulation of mesenchymal cell proliferation involved in prostate gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of odontogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of prostatic bud formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of prostatic bud formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of transcription, DNA-templated IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    respiratory tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    response to axon injury ISO
    Inferred from Sequence Orthology
    more info
     
    response to ethanol ISO
    Inferred from Sequence Orthology
    more info
     
    right lung development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    salivary gland cavitation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    skin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smoothened signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    smoothened signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    somite development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spinal cord dorsal/ventral patterning IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spinal cord dorsal/ventral patterning ISO
    Inferred from Sequence Orthology
    more info
     
    spinal cord motor neuron differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    stem cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    striated muscle cell differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    striated muscle cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    striated muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telencephalon regionalization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    telencephalon regionalization ISO
    Inferred from Sequence Orthology
    more info
     
    thalamus development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    thalamus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thymus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    thyroid gland development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    tongue development ISO
    Inferred from Sequence Orthology
    more info
     
    tongue morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    trachea development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    trachea morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculature development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    vasculogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vasculogenesis involved in coronary vascular morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    ventral spinal cord interneuron specification ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    axon ISO
    Inferred from Sequence Orthology
    more info
     
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    membrane raft ISO
    Inferred from Sequence Orthology
    more info
     
    neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    proteinaceous extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    transport vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    Preferred Names
    sonic hedgehog protein
    Names
    HHG-1
    hemimelic extra toes
    short digits

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_009170.3NP_033196.1  sonic hedgehog protein precursor

      See identical proteins and their annotated locations for NP_033196.1

      Status: VALIDATED

      Source sequence(s)
      AK077688, BC063087
      Consensus CDS
      CCDS19146.1
      UniProtKB/Swiss-Prot
      Q62226
      Related
      ENSMUSP00000002708, OTTMUSP00000023583, ENSMUST00000002708, OTTMUST00000050499
      Conserved Domains (3) summary
      cd00081
      Location:199349
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam01079
      Location:188423
      Hint; Hint module
      pfam01085
      Location:40185
      HH_signal; Hedgehog amino-terminal signalling domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      28456840..28467101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535649.3XP_006535712.1  

      Conserved Domains (3) summary
      cd00081
      Location:85235
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam01079
      Location:74309
      Hint; Hint module
      pfam01085
      Location:171
      HH_signal; Hedgehog amino-terminal signalling domain
    2. XM_006535648.3XP_006535711.1  

      Conserved Domains (3) summary
      cd00081
      Location:108258
      Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...
      pfam01079
      Location:97332
      Hint; Hint module
      pfam01085
      Location:1094
      HH_signal; Hedgehog amino-terminal signalling domain