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    Edn1 endothelin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24323, updated on 26-May-2016
    Official Symbol
    Edn1provided by RGD
    Official Full Name
    endothelin 1provided by RGD
    Primary source
    RGD:2532
    See related
    Ensembl:ENSRNOG00000014361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Et1
    Summary
    activates ERK1/2 mediated signaling; may play a role in regulation of cardiac contractile force [RGD, Feb 2006]
    Orthologs
    Location:
    17p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    105 current Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (22137324..22143324, complement)
    104 previous assembly Rnor_5.0 (GCF_000001895.4) 17 NC_005116.3 (24117499..24124188, complement)

    Chromosome 17 - NC_005116.4Genomic Context describing neighboring genes Neighboring gene similar to hematological and neurological expressed 1 isoform 2 Neighboring gene uncharacterized LOC102547930 Neighboring gene uncharacterized LOC102548003 Neighboring gene zinc finger protein 40-like

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    cytokine activity ISO
    Inferred from Sequence Orthology
    more info
     
    endothelin A receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelin A receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    endothelin B receptor binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    endothelin B receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    hormone activity ISO
    Inferred from Sequence Orthology
    more info
     
    receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    artery smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    artery smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    blood vessel morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    body fluid secretion IEA
    Inferred from Electronic Annotation
    more info
     
    body fluid secretion ISO
    Inferred from Sequence Orthology
    more info
     
    calcium-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    calcium-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cartilage development IEA
    Inferred from Electronic Annotation
    more info
     
    cartilage development ISO
    Inferred from Sequence Orthology
    more info
     
    cell growth IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    cell surface receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    cell-cell signaling ISO
    Inferred from Sequence Orthology
    more info
     
    cellular response to calcium ion IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to fatty acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to glucocorticoid stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interferon-gamma IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to interleukin-1 IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to mineralocorticoid stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to peptide hormone stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    cellular response to tumor necrosis factor IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    dorsal/ventral pattern formation ISO
    Inferred from Sequence Orthology
    more info
     
    epithelial fluid transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    glucose transport IEA
    Inferred from Electronic Annotation
    more info
     
    glucose transport ISO
    Inferred from Sequence Orthology
    more info
     
    heart development IEA
    Inferred from Electronic Annotation
    more info
     
    heart development ISO
    Inferred from Sequence Orthology
    more info
     
    histamine secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
     
    inositol phosphate-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
     
    inositol phosphate-mediated signaling ISO
    Inferred from Sequence Orthology
    more info
     
    intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    maternal process involved in parturition IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    membrane depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    middle ear morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    middle ear morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    multicellular organism aging IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    negative regulation of cAMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cAMP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cellular protein metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of cellular protein metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of hormone secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of nitric-oxide synthase biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of nitric-oxide synthase biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of smooth muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of transcription from RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of transcription from RNA polymerase II promoter ISO
    Inferred from Sequence Orthology
    more info
     
    neural crest cell development IEA
    Inferred from Electronic Annotation
    more info
     
    neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
     
    NOT neutrophil chemotaxis ISO
    Inferred from Sequence Orthology
    more info
     
    nitric oxide transport IEA
    Inferred from Electronic Annotation
    more info
     
    nitric oxide transport ISO
    Inferred from Sequence Orthology
    more info
     
    patterning of blood vessels IEA
    Inferred from Electronic Annotation
    more info
     
    patterning of blood vessels ISO
    Inferred from Sequence Orthology
    more info
     
    peptide hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    peptide hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    phosphatidylinositol 3-kinase signaling IEA
    Inferred from Electronic Annotation
    more info
     
    phosphatidylinositol 3-kinase signaling ISO
    Inferred from Sequence Orthology
    more info
     
    phospholipase D-activating G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    phospholipase D-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of JUN kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of JUN kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of MAP kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cardiac muscle hypertrophy IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cardiac muscle hypertrophy ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cell size IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cell size ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of heart rate ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of hormone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of hormone secretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of mitotic nuclear division IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of mitotic nuclear division ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of odontogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of prostaglandin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of prostaglandin-endoperoxide synthase activity IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of prostaglandin-endoperoxide synthase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of receptor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of receptor biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of renal sodium excretion IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of renal sodium excretion ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of sarcomere organization IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of sarcomere organization ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of smooth muscle contraction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of smooth muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of urine volume IEA
    Inferred from Electronic Annotation
    more info
     
    positive regulation of urine volume ISO
    Inferred from Sequence Orthology
    more info
     
    prostaglandin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    prostaglandin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C deactivation IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C deactivation ISO
    Inferred from Sequence Orthology
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    protein kinase C-activating G-protein coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of blood pressure ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of pH IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of pH ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    regulation of systemic arterial blood pressure by endothelin IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of systemic arterial blood pressure by endothelin ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of vasoconstriction IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory gaseous exchange IEA
    Inferred from Electronic Annotation
    more info
     
    respiratory gaseous exchange ISO
    Inferred from Sequence Orthology
    more info
     
    response to activity IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to amino acid IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to dexamethasone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to hypoxia ISO
    Inferred from Sequence Orthology
    more info
     
    response to leptin IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to lipopolysaccharide IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to muscle stretch IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to nicotine IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to ozone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to prostaglandin F IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to salt IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to testosterone IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    response to transforming growth factor beta IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    rhythmic excitation IEA
    Inferred from Electronic Annotation
    more info
     
    rhythmic excitation ISO
    Inferred from Sequence Orthology
    more info
     
    sensory perception of pain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    skeletal system development ISO
    Inferred from Sequence Orthology
    more info
     
    superoxide anion generation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vasoconstriction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    vasoconstriction ISO
    Inferred from Sequence Orthology
    more info
     
    vein smooth muscle contraction IEA
    Inferred from Electronic Annotation
    more info
     
    vein smooth muscle contraction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    Weibel-Palade body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    basal part of cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    rough endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Preferred Names
    endothelin-1
    Names
    ET-1
    PPET1
    preproendothelin-1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012548.2NP_036680.1  endothelin-1 preproprotein

      See identical proteins and their annotated locations for NP_036680.1

      Status: VALIDATED

      Source sequence(s)
      AABR07027270
      UniProtKB/Swiss-Prot
      P22388
      Related
      ENSRNOP00000019361, ENSRNOT00000019361
      Conserved Domains (2) summary
      pfam00322
      Location:4878
      Endothelin; Endothelin family
      smart00272
      Location:109130
      END; Endothelin

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Rnor_6.0 Primary Assembly

    Genomic

    1. NC_005116.4 Reference Rnor_6.0 Primary Assembly

      Range
      22137324..22143324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Rn_Celera

    Genomic

    1. AC_000085.1 Alternate Rn_Celera

      Range
      22134975..22140901 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)