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Notch1 notch 1 [ Mus musculus (house mouse) ]

Gene ID: 18128, updated on 19-Jul-2014
Official Symbol
Notch1provided by MGI
Official Full Name
notch 1provided by MGI
Primary source
MGI:97363
Locus tag
RP23-306D20.12-001
See related
Ensembl:ENSMUSG00000026923; Vega:OTTMUSG00000012795
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
N1; Mis6; Tan1; lin-12; 9930111A19Rik
See Notch1 in Epigenomics, MapViewer
Location:
2 A3; 2 18.91 cM
Exon count:
34
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 2 NC_000068.7 (26457902..26503822, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene SEC16 homolog A (S. cerevisiae) Neighboring gene uncharacterized LOC102639807 Neighboring gene microRNA mir-6996 Neighboring gene uncharacterized LOC102639736 Neighboring gene uncharacterized LOC102639879

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription IDA
Inferred from Direct Assay
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
core promoter binding IDA
Inferred from Direct Assay
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
Notch signaling involved in heart development IGI
Inferred from Genetic Interaction
more info
 
Notch signaling involved in heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling involved in heart development ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway IC
Inferred by Curator
more info
PubMed 
Notch signaling pathway IDA
Inferred from Direct Assay
more info
 
Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
anagen IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IEA
Inferred from Electronic Annotation
more info
 
aortic valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
apoptotic process involved in embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
arterial endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
atrioventricular node development IMP
Inferred from Mutant Phenotype
more info
 
atrioventricular valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
auditory receptor cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
axonogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
branching morphogenesis of an epithelial tube IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
cardiac chamber formation IMP
Inferred from Mutant Phenotype
more info
 
cardiac epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 
cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
cardiac right atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
cardiac right ventricle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cardiac septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
cardiac vascular smooth muscle cell development IMP
Inferred from Mutant Phenotype
more info
 
cardiac ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
 
cellular response to follicle-stimulating hormone stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to vascular endothelial growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
compartment pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
coronary artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
coronary vein morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic hindlimb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic limb morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
endocardial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
endocardial cushion morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardium development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
epidermis development IGI
Inferred from Genetic Interaction
more info
PubMed 
epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial to mesenchymal transition involved in endocardial cushion formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
forebrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
growth involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
heart development ISO
Inferred from Sequence Orthology
more info
 
heart looping IGI
Inferred from Genetic Interaction
more info
PubMed 
heart trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
humoral immune response IGI
Inferred from Genetic Interaction
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response to antigenic stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
interleukin-4 secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
left/right axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesenchymal cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitral valve formation ISO
Inferred from Sequence Orthology
more info
 
multicellular organismal development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of anoikis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration involved in sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of endothelial cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myotube differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of oligodendrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ossification IMP
Inferred from Mutant Phenotype
more info
 
negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of photoreceptor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of pro-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of stem cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron fate commitment IGI
Inferred from Genetic Interaction
more info
PubMed 
osteoblast fate commitment NAS
Non-traceable Author Statement
more info
PubMed 
pericardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 
positive regulation of JAK-STAT cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of astrocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endothelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of ephrin receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
positive regulation of epithelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
 
positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neuroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription of Notch receptor target IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription of Notch receptor target ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
prostate gland epithelium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
pulmonary valve morphogenesis ISO
Inferred from Sequence Orthology
more info
 
regulation of cardioblast proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of cell adhesion involved in heart morphogenesis IC
Inferred by Curator
more info
PubMed 
regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of developmental process IEA
Inferred from Electronic Annotation
more info
 
regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of epithelial cell proliferation involved in prostate gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of extracellular matrix assembly IMP
Inferred from Mutant Phenotype
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription from RNA polymerase II promoter IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
response to muramyl dipeptide IDA
Inferred from Direct Assay
more info
 
secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
somatic stem cell division IDA
Inferred from Direct Assay
more info
PubMed 
somatic stem cell division IGI
Inferred from Genetic Interaction
more info
PubMed 
spermatogenesis ISO
Inferred from Sequence Orthology
more info
 
sprouting angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
tube formation ISO
Inferred from Sequence Orthology
more info
 
vasculogenesis involved in coronary vascular morphogenesis IMP
Inferred from Mutant Phenotype
more info
 
venous endothelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
ventricular trabecula myocardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
MAML1-RBP-Jkappa- ICN1 complex ISO
Inferred from Sequence Orthology
more info
 
acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
 
cell IGI
Inferred from Genetic Interaction
more info
PubMed 
cell periphery IDA
Inferred from Direct Assay
more info
 
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IC
Inferred by Curator
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IMP
Inferred from Mutant Phenotype
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
receptor complex ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
neurogenic locus notch homolog protein 1
Names
neurogenic locus notch homolog protein 1
mT14
p300
Motch A
Notch gene homolog 1
major type A protein
transmembrane receptor Notch1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008714.3NP_032740.3  neurogenic locus notch homolog protein 1 precursor

    See proteins identical to NP_032740.3

    Status: VALIDATED

    Source sequence(s)
    BC138441, BF318436, BY233933
    Consensus CDS
    CCDS15806.1
    UniProtKB/Swiss-Prot
    Q01705
    Related
    ENSMUSP00000028288, OTTMUSP00000013754, ENSMUST00000028288, OTTMUST00000030656
    Conserved Domains (10) summary
    pfam06816
    Location:15661622
    Blast Score: 272
    NOD; NOTCH protein
    smart00004
    Location:14421479
    Blast Score: 125
    NL; Domain found in Notch and Lin-12
    cd00054
    Location:869905
    Blast Score: 125
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:19122024
    Blast Score: 295
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:14851522
    Blast Score: 140
    Notch; LNR domain
    pfam06247
    Location:12411397
    Blast Score: 94
    Plasmod_Pvs28; Plasmodium ookinete surface protein Pvs28
    pfam07684
    Location:16601721
    Blast Score: 254
    NODP; NOTCH protein
    pfam11936
    Location:24532517
    Blast Score: 299
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:19222015
    Blast Score: 182
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:20532103
    Blast Score: 88
    Ank_4; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000068.7 

    Range
    26457902..26503822
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Mm_Celera

Genomic

  1. AC_000024.1 

    Range
    26175736..26221759
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)