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Agtr1a angiotensin II receptor, type 1a [ Mus musculus (house mouse) ]

Gene ID: 11607, updated on 19-Sep-2014
Official Symbol
Agtr1aprovided by MGI
Official Full Name
angiotensin II receptor, type 1aprovided by MGI
Primary source
MGI:MGI:87964
See related
Ensembl:ENSMUSG00000049115; Vega:OTTMUSG00000000668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AT1; AG2S; AT1a; AT2R1; Agtr1; AT2R1A; Agtr-1a; AI551199; Angtr-1a; 1810074K20Rik
See Agtr1a in Epigenomics, MapViewer
Location:
13 A3.2; 13 13.19 cM
Exon count:
4
Annotation release Status Assembly Chr Location
104 current GRCm38.p2 (GCF_000001635.22) 13 NC_000079.6 (30336356..30382867)

Chromosome 13 - NC_000079.6Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 3 Neighboring gene membrane bound O-acyltransferase domain containing 1 Neighboring gene non-POU-domain-containing, octamer binding protein pseudogene Neighboring gene ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 Neighboring gene uncharacterized LOC102638578

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC37610

Gene Ontology Provided by MGI

Function Evidence Code Pubs
D1 dopamine receptor binding ISO
Inferred from Sequence Orthology
more info
 
G-protein alpha-subunit binding ISO
Inferred from Sequence Orthology
more info
 
G-protein coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
angiotensin type I receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
angiotensin type I receptor activity ISO
Inferred from Sequence Orthology
more info
 
angiotensin type II receptor activity ISO
Inferred from Sequence Orthology
more info
 
bradykinin receptor binding ISO
Inferred from Sequence Orthology
more info
 
peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
signal transducer activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IC
Inferred by Curator
more info
PubMed 
G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
activation of Janus kinase activity ISO
Inferred from Sequence Orthology
more info
 
angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
blood vessel development IGI
Inferred from Genetic Interaction
more info
PubMed 
brain renin-angiotensin system IMP
Inferred from Mutant Phenotype
more info
PubMed 
calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
cellular response to dexamethasone stimulus ISO
Inferred from Sequence Orthology
more info
 
dopamine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
drinking behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
drinking behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
drinking behavior ISO
Inferred from Sequence Orthology
more info
 
heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
kidney development ISO
Inferred from Sequence Orthology
more info
 
NOT negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of smooth muscle cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phospholipase C-activating G-protein coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
phospholipase C-activating angiotensin-activated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase C-activating angiotensin-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood pressure IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood pressure IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood pressure ISO
Inferred from Sequence Orthology
more info
 
positive regulation of branching involved in ureteric bud morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol esterification ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytokine secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phospholipase A2 activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of receptor recycling ISO
Inferred from Sequence Orthology
more info
 
positive regulation of superoxide anion generation ISO
Inferred from Sequence Orthology
more info
 
regulation of pH ISO
Inferred from Sequence Orthology
more info
 
regulation of renal output by angiotensin IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smooth muscle cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of systemic arterial blood pressure by circulatory renin-angiotensin IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
renin secretion into blood stream IMP
Inferred from Mutant Phenotype
more info
PubMed 
renin-angiotensin regulation of aldosterone production IMP
Inferred from Mutant Phenotype
more info
PubMed 
renin-angiotensin regulation of aldosterone production ISO
Inferred from Sequence Orthology
more info
 
response to estrogen ISO
Inferred from Sequence Orthology
more info
 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
vasoconstriction ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
dendrite ISO
Inferred from Sequence Orthology
more info
 
endomembrane system ISO
Inferred from Sequence Orthology
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
 
organelle outer membrane ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
recycling endosome ISO
Inferred from Sequence Orthology
more info
 
vesicle lumen ISO
Inferred from Sequence Orthology
more info
 
vesicle membrane ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
type-1A angiotensin II receptor
Names
type-1A angiotensin II receptor
angiotensin receptor 1
angiotensin receptor 1a
angiotensin II type-1A receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177322.3NP_796296.1  type-1A angiotensin II receptor

    See proteins identical to NP_796296.1

    Status: VALIDATED

    Source sequence(s)
    AL607131, CJ066917
    Consensus CDS
    CCDS26415.1
    UniProtKB/Swiss-Prot
    P29754
    Related
    ENSMUSP00000070958, OTTMUSP00000000614, ENSMUST00000066412, OTTMUST00000001293
    Conserved Domains (2) summary
    pfam00001
    Location:51302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:37156
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p2 C57BL/6J

Genomic

  1. NC_000079.6 

    Range
    30336356..30382867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006516534.1XP_006516597.1  

    See proteins identical to XP_006516597.1

    UniProtKB/Swiss-Prot
    P29754
    Conserved Domains (2) summary
    pfam00001
    Location:51302
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam10328
    Location:37156
    7TM_GPCR_Srx; Serpentine type 7TM GPCR chemoreceptor Srx

Alternate Mm_Celera

Genomic

  1. AC_000035.1 

    Range
    30550710..30597281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)